Cold spraying modified layer and application thereof

A technology of cold spraying and modified layers, which is applied in coatings, pharmaceutical formulations, medical science, etc., can solve problems such as inability to combine eye tissues and loose artificial corneas, and achieve the effects of optimizing biocompatibility and facilitating proliferation and growth

Active Publication Date: 2022-01-11
XIANGYA HOSPITAL CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional research usually uses polymer materials as scaffolding materials for artificial corneas, and polymers are biologically inert materials that cannot form a firm bond with eye tissues, which can easily cause artificial corneas to loosen, resulting in a series of complications

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A. Weigh 23.62g Ca(NO 3 ) 2 4H 2 O and 1.5g mannose erythritol fat are dissolved in 500mL distilled water, stir with glass rod in the dissolving process;

[0030] B. Weigh 7.92g (NH 4 ) 2 HPO 4 Dissolve in 500mL distilled water, stirring with a glass rod during the dissolution process;

[0031] C. Ca(NO 3 ) 2 4H 2 O solution and ammonia water were drained into a three-necked flask with a glass rod, and then (NH 4 ) 2 HPO 4 The solution was drained into a separatory funnel with a glass rod, and the neck of the funnel was inserted into a side port of a three-necked flask for titration. 4 ) 2 HPO 4 After the solution is all added dropwise to the flask, stop the side port of the three-necked flask with a stopper, wherein the effect of ammonia water is to adjust the pH value of the solution to 9.6;

[0032] D. Turn on the constant temperature water bath device, keep warm at 85°C for 4h, then cool down to room temperature naturally, and filter the reaction produ...

Embodiment 2

[0035] A. Weigh 23.62g Ca(NO 3 ) 2 4H 2 O and 1.5g rhamnolipid were dissolved in 500mL distilled water, and stirred with a glass rod during the dissolution process;

[0036] B. Weigh 7.92g (NH 4 ) 2 HPO 4 Dissolve in 500mL distilled water, stirring with a glass rod during the dissolution process;

[0037] C. Ca(NO 3 ) 2 4H 2 O solution and ammonia water were drained into a three-necked flask with a glass rod, and then (NH 4 ) 2 HPO 4 The solution was drained into a separatory funnel with a glass rod, and the neck of the funnel was inserted into a side port of a three-necked flask for titration. 4 ) 2 HPO 4 After the solution is all added dropwise to the flask, stop the side port of the three-necked flask with a stopper, wherein the effect of ammonia water is to adjust the pH value of the solution to 9.6;

[0038] D. Turn on the constant temperature water bath device, keep warm at 85°C for 4h, then cool down to room temperature naturally, and filter the reaction p...

Embodiment 3

[0041] A. Weigh 23.62g Ca(NO 3 ) 2 4H 2 O and 1.5g sophorolipids were dissolved in 500mL distilled water, and stirred with a glass rod during the dissolution process;

[0042] B. Weigh 7.92g (NH 4 ) 2 HPO 4 Dissolve in 500mL distilled water, stirring with a glass rod during the dissolution process;

[0043] C. Ca(NO 3 ) 2 4H 2 O solution and ammonia water were drained into a three-necked flask with a glass rod, and then (NH 4 ) 2 HPO 4 The solution was drained into a separatory funnel with a glass rod, and the neck of the funnel was inserted into a side port of a three-necked flask for titration. 4 ) 2 HPO 4 After the solution is all added dropwise to the flask, stop the side port of the three-necked flask with a stopper, wherein the effect of ammonia water is to adjust the pH value of the solution to 9.6;

[0044] D. Turn on the constant temperature water bath device, keep warm at 85°C for 4h, then cool down to room temperature naturally, and filter the reaction...

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Abstract

The invention relates to a cold spraying modified layer and application thereof. In the process of preparing hydroxyapatite nano-powder, a surfactant is added to be beneficial to reducing the particle size of the nano-powder, and the change can optimize the biocompatibility, corrosion resistance and eye irritation of the cold spraying modified layer in later. However, after four different kinds of surfactants (sodium dodecyl benzene sulfonate, mannosylerythritol lipid, rhamnolipid and sophorolipid) are compared, it is found that the sodium dodecyl benzene sulfonate is not beneficial to the cytotoxicity and eye irritation of the modified layer of an artificial cornea titanium bracket, the reason possibly lies in that the whole preparation technology can hardly realize 100% removal of the surfactant, and compared with sodium dodecyl benzene sulfonate, mannosylerythritol lipid, rhamnolipid, sophorolipid and other glycolipid biosurfactants, proliferation and growth of cells are more facilitated.

Description

technical field [0001] The invention relates to the field of cold spraying, in particular to a modified layer of cold spraying and its application. Background technique [0002] Cold spraying, also known as cold aerodynamic spraying, is a spraying technology based on the principle of aerodynamics. The cold spraying process uses high-pressure gas to generate supersonic flow through the Laval nozzle, and sends powder particles into the high-speed airflow from the axial direction. After acceleration, they hit the substrate in a completely solid state and deposit on the substrate through large plastic deformation. The surface forms a coating. Due to the advantages of low temperature, little impact on the structure of materials, high deposition rate, and low porosity of coatings, cold spraying technology provides an important process for preparing high-performance oxidation-free coatings and nanostructured coatings. [0003] Hydroxyapatite bioactive ceramic is a calcium phospha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C23C24/04A61L27/06A61L27/32A61L27/50
CPCC23C24/04A61L27/06A61L27/32A61L27/50A61L2430/16A61L2400/12
Inventor 郑巍陈娜文丹毛俊峰
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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