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Mesoporous silicon nano material, preparation method and application thereof

A nanomaterial and mesoporous silicon technology, applied in the field of materials, can solve the problems of difficult to control the thickness and pore size of the shell layer, difficult to control the size of the center core, and few reports on the synthesis method of dendritic mesoporous silicon nanomaterials. Conducive to loading and complete release, overcoming difficulty in complete release, and enhancing the level of immune response

Active Publication Date: 2022-01-21
LANZHOU INST OF VETERINARY SCI CHINESE ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are few reports on the synthesis methods of dendritic mesoporous silicon nanomaterials with "core-cone structure".
In the reported methods, it is difficult to control either the size of the central core, or the shell thickness and pore size
So far, the synthesis of dendritic mesoporous silicon nanomaterials with "core-cone structure" remains a great challenge

Method used

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  • Mesoporous silicon nano material, preparation method and application thereof
  • Mesoporous silicon nano material, preparation method and application thereof
  • Mesoporous silicon nano material, preparation method and application thereof

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preparation example Construction

[0049] The invention also provides a preparation method of the mesoporous silicon nanometer material.

[0050] A preparation method of mesoporous silicon nanomaterials is:

[0051] (1) Weigh 0.3 mg of solid silica, add 6 mL of solvent A, and disperse ultrasonically for 30 minutes; add 4 mL of 25% cetyltrimethylammonium chloride solution, 35 mg of basic catalyst, and put in a magnet , in a 60°C oil bath, magnetically stirred at a speed of 400rpm for 1h;

[0052] (2) Add 8.75 mL of solvent B to the mixed solution in step (1), and slowly add 1.25 mL of silicon source after 20 min; the above mixture is reacted at 60 ° C and 150 rpm for 24 h;

[0053] (3) The solid-liquid separation of the solution in step (2), and washing the solid phase with ethanol and water for 2 to 4 times;

[0054] (4) Calcining the precipitate obtained in step (3) at 600° C. for 6 hours to obtain the mesoporous silicon nanomaterial.

[0055] Further, the basic catalyst in step (1) is triethanolamine.

[...

Embodiment 1

[0067] Preparation of Mesoporous Silicon Nanomaterials

[0068] (1) Weigh 0.3 mg of solid silicon dioxide (particle size 130 nm), add 6 mL of water, and ultrasonically disperse for 30 min; add 4 mL of 25% cetyltrimethylammonium chloride solution and 35 mg of triethanolamine to the solution, Put into a magnet, stir magnetically at 400rpm in an oil bath at 60°C for 1h;

[0069] (2) Add 8.75 mL of chlorobenzene, and slowly add 1.25 mL of tetraethyl orthosilicate after 20 minutes. The above mixture was reacted at 60°C and 150rpm for 24h;

[0070] (3) After the reaction is finished, centrifuge at 10000rpm for 10min to collect the precipitate, which is washed 3 times with ethanol and water;

[0071] (4) The obtained solid was calcined at 600° C. for 6 hours to obtain a dendritic mesoporous silicon nanomaterial with a particle size of 237 nm and a “core-cone structure”.

[0072] Its structure is as figure 1 (Transmission electron microscope image of mesoporous silicon nanomateria...

Embodiment 2

[0075] Preparation of Foot-and-Mouth Disease Virus-like Particle Vaccine

[0076] (1) Weigh 6 mg of dendritic mesoporous silicon nanomaterials with a "core-cone structure", add 2 mL of PBS buffer solution, and prepare a 3 mg / mL solution

[0077] (2) The solution was mixed with 0.5 mg / mL FMD virus-like particle antigen at a ratio of 1:1, and mixed overnight at 4°C to obtain an animal vaccine.

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Abstract

The invention belongs to the technical field of materials, and particularly relates to a mesoporous silicon nano material, a preparation method and application thereof. The mesoporous silicon nano material is of a core-cone structure; the interior of the material is a silicon dioxide solid core, and the exterior of the material is a dendritic mesoporous silicon shell layer radiating outwards from the core. The size of the silicon dioxide core is 108+ / -10nm; and the thickness of the mesoporous silicon shell layer is 66+ / -10nm. The mesoporous silicon nano-material is spherical, and the particle size of the mesoporous silicon nano-material is 237+ / -10nm. The mesoporous silicon nano material has the advantages of large specific surface area and pore volume, uniform particle size, stable structure and high biological safety. According to the present invention, the foot and mouth disease virus-like particle antigen can be loaded and slowly released, and advantages of high protein loading capacity, low cytotoxicity, good blood compatibility and low tissue and organ toxicity are provided. As an adjuvant, the mesoporous silicon nano material can enhance the immune response level and improve the challenge protection rate.

Description

technical field [0001] The invention belongs to the technical field of materials, and in particular relates to a mesoporous silicon nanometer material and its preparation method and application. Background technique [0002] Dendritic mesoporous silicon material is a kind of "star" mesoporous material developed in recent years. It has a high specific surface area and a large pore volume because of its dendritic large pore structure that radiates from the inside to the outside. , higher pore permeability and easier access to the inner surface of the particle. Therefore, dendritic mesoporous silica materials have been widely used in drug / protein / gene delivery, catalysis, biosensing, chromatography columns and other fields. [0003] Dendritic mesoporous silicon materials have structural diversity and complexity, and can be divided into core-shell structures, hollow structures, and rattle-shaped structures according to their inner cores. Different structures have different pro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B33/18A61K47/04A61K39/39B82Y40/00B82Y30/00B82Y5/00
CPCC01B33/18A61K47/02A61K39/39B82Y40/00B82Y30/00B82Y5/00C01P2004/64C01P2004/62C01P2004/32C01P2006/12C01P2006/14C01P2006/16Y02A50/30
Inventor 郭慧琛茹嘉喜孙世琪尹双辉张韵白满元吴金恩董虎
Owner LANZHOU INST OF VETERINARY SCI CHINESE ACAD OF AGRI SCI
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