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Sargassum fusiforme polysaccharide with remarkable anti-photoaging activity and application thereof

A hijiki polysaccharide, anti-photoaging technology, applied in the direction of organic active ingredients, medical preparations containing active ingredients, applications, etc., can solve the problems of unfavorable absorption and utilization, insignificant efficacy, and large molecular weight of polysaccharides, and achieve easy operation , Increase the content of hydroxyproline, increase the effect of total sugar content

Active Publication Date: 2022-02-01
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ji Desheng's master's thesis "Separation and Purification of Hijiki Polysaccharides, Structural Identification and Antagonism of Skin Photoaging Damage Caused by UVB Radiation" explored the antagonism of Hijiki polysaccharides on skin photoaging and oxidative damage, but the prepared polysaccharides have large molecular weight and low molecular weight. It is beneficial to the absorption and utilization of the body, which limits its application, and it mainly exerts anti-photoaging activity by reducing oxidative damage, and its efficacy is not significant compared with the positive control (hyaluronic acid)

Method used

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  • Sargassum fusiforme polysaccharide with remarkable anti-photoaging activity and application thereof
  • Sargassum fusiforme polysaccharide with remarkable anti-photoaging activity and application thereof
  • Sargassum fusiforme polysaccharide with remarkable anti-photoaging activity and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A hijiki degraded polysaccharide, the preparation method of which is as follows:

[0032] (1) Raw material pretreatment: Use a low-temperature vibrating cell-level ultrafine pulverizer to pulverize the washed and dried hijiki for 10 minutes, set the temperature at -20°C to obtain hijiki superfine powder, and pass through 60 meshes Sieve; weigh 100g of hijiki superfine powder, add 400mL of ethanol with a volume fraction of 95%, reflux three times in a slightly boiling state for a total of 5h, collect the precipitate, and dry to obtain pretreated hijiki powder.

[0033] (2) Extraction of the crude polysaccharide of Hijiki: adding the Hijiki powder into pure water according to the mass volume ratio of 1:50g / mL in step (1) to obtain the Hijiki aqueous solution; The crude polysaccharides of Chickweed, the extraction temperature is 100°C, the extraction time is 4h, the extract is filtered to remove residue, the filtrate is evaporated and concentrated, 95% ethanol is slowly adde...

Embodiment 2

[0036] A hijiki degraded polysaccharide, the preparation method of which is as follows:

[0037] (1) Raw material pretreatment: Use a low-temperature vibrating cell-level ultrafine pulverizer to pulverize the washed and dried hijiki for 5 minutes, set the temperature at -17°C to obtain hijiki superfine powder, and pass through 60 meshes Sieve; weigh 100 g of hijiki superfine powder, add 400 mL of ethanol with a volume fraction of 95%, reflux three times in a slightly boiling state for a total of 4 hours, collect the precipitate, and dry to obtain pretreated hijiki powder.

[0038] (2) Extraction of hijiki crude polysaccharides: adding the hijiki powder into pure water according to the mass volume ratio of 1:40g / mL in step (1) to obtain the hijiki aqueous solution; ultrasonically assisted extraction of hijiki crude polysaccharides For polysaccharides, the hijiki polysaccharide aqueous solution was placed in a cell ultrasonic breaker, ultrasonicated for 40 minutes at a power of ...

Embodiment 3

[0041] A hijiki degraded polysaccharide, the preparation method of which is as follows:

[0042] (1) Raw material pretreatment: Use a low-temperature vibrating cell-level ultrafine pulverizer to pulverize the washed and dried hijiki for 10 minutes, set the temperature at -20°C to obtain hijiki superfine powder, and pass through 60 meshes Sieve; weigh 100g of hijiki superfine powder, add 400mL of ethanol with a volume fraction of 95%, reflux three times in a slightly boiling state for a total of 5h, collect the precipitate, and dry to obtain pretreated hijiki powder.

[0043] (2) Extraction of the crude polysaccharide of Hijiki: adding the Hijiki powder into pure water according to the mass volume ratio of 1:50g / mL in step (1) to obtain the Hijiki aqueous solution; The crude polysaccharides of Chickweed, the extraction temperature is 100°C, the extraction time is 4h, the extract is filtered to remove residue, the filtrate is evaporated and concentrated, 95% ethanol is slowly ad...

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Abstract

The invention discloses sargassum fusiforme polysaccharide with remarkable anti-photoaging activity and an application thereof. The molecular weight of the sargassum fusiforme polysaccharide is 28-130 kDa, the content of uronic acid is 21-33 wt%, the content of reducing sugar is 2-7 wt%, monosaccharide is composed of fucose, galactose, glucose, xylose, galacturonic acid and glucuronic acid, and the molar ratio of the fucose to the galactose to the glucose to the xylose to the galacturonic acid to the glucuronic acid is (39-46): (16-17): (2-3): (4-5): (10-16): (20-22). The sargassum fusiforme polysaccharide can improve the survival rate of human immortalized epidermis cells HaCaT and the content of hydroxyproline after UVB radiation, reduces the levels of matrix metalloproteinases MMP-1 and MMP-3, has remarkable anti-photoaging activity, can be used for development of anti-photoaging drugs or functional foods, and has important significance for deep processing of sargassum fusiforme.

Description

technical field [0001] The invention belongs to the field of deep processing of hijiki, and in particular relates to a hijiki polysaccharide with significant anti-photoaging activity and an application thereof. Background technique [0002] Sargassum fusiforme, also known as staghorn, lantern vegetable, jade seaweed, etc., belongs to Phaeophyta, Fucusaceae, and Sargassumaceae. It is a large-scale economical medicinal and edible seaweed. Hijiki is rich in polysaccharides, proteins, vitamins, amino acids, mannitol and other functional components, and has high development and utilization value. Polysaccharide is one of the important active ingredients in hijiki. Studies have found that hijiki polysaccharides have various effects such as anti-oxidation, anti-tumor, lowering blood sugar, lowering blood lipids, immune regulation, and delaying aging. However, there are few reports on the research and application of hijiki polysaccharides in anti-photoaging. In addition, hijiki po...

Claims

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Application Information

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IPC IPC(8): C08B37/00A61K31/715A61K36/02A61P17/18A61K8/73A61Q19/08A23L33/125
CPCC08B37/0087C08B37/0003A61K31/715A61K36/02A61P17/18A61K8/73A61Q19/08A23L33/125A61K2800/81A61K2800/84A23V2002/00A23V2250/51A23V2200/318A23V2200/302
Inventor 游丽君姚烷梓
Owner SOUTH CHINA UNIV OF TECH
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