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Natural polysaccharide nano hydrogel mask based on hollow nanoparticles and preparation method thereof

A nano-hydrogel, hydrogel mask technology, applied in skin care preparations, medical preparations containing active ingredients, pharmaceutical formulations, etc., to achieve the effects of reducing MDA content, brightening skin tone, and delaying aging

Pending Publication Date: 2022-02-08
LUOYANG NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no mask on the market that uses nanotechnology to wrap natural substances such as chia seed polysaccharide, grape seed polysaccharide, motherwort mixed polysaccharide, wolfberry polysaccharide, tremella polysaccharide, etc., and the mask does not contain chemical additives and has good Whitening, moisturizing, anti-aging and other effects

Method used

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  • Natural polysaccharide nano hydrogel mask based on hollow nanoparticles and preparation method thereof
  • Natural polysaccharide nano hydrogel mask based on hollow nanoparticles and preparation method thereof
  • Natural polysaccharide nano hydrogel mask based on hollow nanoparticles and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0045] The specific preparation method of the natural polysaccharide nano hydrogel facial mask based on hollow nanoparticles comprises the following steps:

[0046] (1) Weigh 1 g of alginic acid derivative and add it into 100 ml of distilled water, stir evenly to obtain solution I;

[0047] (2) Weigh 1 g of conjugated linoleic acid and add it into distilled water to make it fully dissolved, then add 85 ml of methanol, stir evenly, and obtain solution II;

[0048] (3) Pour solution II into solution I and stir evenly to obtain solution III;

[0049] (4) Weigh 0.5 g of carbodiimide hydrochloride and add it to 15 ml of methanol, stir evenly for 24 hours under a magnetic stirrer to fully dissolve it, and then add it to solution III to obtain solution IV;

[0050] (5) Centrifuge the solution IV at least twice under the condition of 5000r / 30min, wash each time with methanol as a solvent, and wash with ether for the last time to obtain a conjugated linoleic acid-alginic acid derivati...

Embodiment 1

[0081] Example 1 and, comparative example 1, comparative example 1-1, preferred example and commercially available facial mask about inhibiting melanin, whitening, anti-oxidation and anti-aging tests and result records:

[0082] (1) Experiments and records of inhibiting melanin whitening:

[0083] Find 80 female volunteers between the ages of 18 and 55. According to the premise of equal distribution, each group has 20 volunteers. At room temperature, select a fixed area on the forehead of each volunteer and use the sample. Once a day, used for a total of 20 days, without using any other products during the test, at room temperature, use a skin pigment analyzer to test the forehead fixed area before use and after 20 days, and get the experimental data, as shown in Table 2:

[0084] Table 2- Comparative analysis of melanin inhibition test results

[0085]

[0086]As can be seen from Table 2, the melanin inhibition rate of embodiment 1, comparative example 1 and preferred exa...

Embodiment 2

[0098] Embodiment 2 and comparative example 2, the preferred example and the test and result records of the facial mask sold on the market about water replenishment and moisturizing:

[0099] Moisturizing experiments and records:

[0100] Find 80 female volunteers between the ages of 18 and 55. According to the premise of equal distribution, each group has 20 volunteers. At room temperature, select a fixed area on the forehead of each volunteer and use the sample. Detect with a skin moisture detector to obtain the experimental data, as shown in Table 3:

[0101] Table 3 - Comparative analysis of water replenishment experiment results

[0102] sample Humidity before use I Humidity value after use II Humidity value III after 2 hours of use Water replenishment rate% (II / I*100%) Moisture retention rate% (III / II*100%) Example 2 26.7 45.7 41.4 171.1 90.5 Comparative example 2 28.6 59.4 55.3 207.6 93.1 Preferred example 27.6 65.8 62.3 ...

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Abstract

The invention relates to a natural polysaccharide nano hydrogel mask based on hollow nanoparticles, the mask is prepared by forming hydrogel after hollow nanoparticles entrap natural polysaccharide mixed liquor, and the natural polysaccharide mixed liquor is prepared from the following components in percentage by mass: 30-50% of natural polysaccharide and 50-70% of gum oil component, the natural polysaccharide is a natural polysaccharide product extracted from motherwort herb, chia seeds, grape seeds, Chinese wolfberry fruits and tremella fuciformis. The polysaccharide nano hydrogel mask provided by the invention contains various natural polysaccharides, has no side effect, and has a relatively good protection effect on skin; natural polysaccharide components are entrapped in the hollow nanoparticles to prepare the polysaccharide nano hydrogel mask, so that the natural components can be better absorbed by skin, and the polysaccharide nano hydrogel mask has remarkable effects in the aspects of resisting oxidation and aging, maintaining epidermal barrier of cuticle, interrupting epidermal melanin, whitening and moisturizing, brightening skin color, making skin elastic and glossy and the like.

Description

technical field [0001] The invention relates to the technical field of skin care facial masks, in particular to a natural polysaccharide nano hydrogel facial mask based on hollow nanoparticles and a preparation method thereof. Background technique [0002] Most alginic acid derivative molecules are connected by β-D-mannuronic acid and α-L-guluronic acid through 1-4 glycosidic bonds, and are composed of anionic linear polymerization composed of GM, MM, and GG fragments in different proportions. thing. Alginic acid derivative molecules are extracted, separated and refined from brown algae. The composition and sequence of molecules extracted from different algae are not necessarily the same, but it will not affect its physical, chemical and biological properties, so it has good biological properties. Compatibility, degradability, low toxicity and spheroidization, so it has a good application effect in the preparation of nanoparticles. In the preparation of nanoparticles, vari...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/9728A61K8/73A61K8/11A61K8/34A61K8/36A61K8/44A61K8/04A61Q19/08A61Q19/02A61Q19/00
CPCA61K8/9789A61K8/9728A61K8/73A61K8/361A61K8/733A61K8/44A61K8/11A61K8/345A61K8/735A61K8/042A61Q19/08A61Q19/02A61Q19/00A61K2800/5922
Inventor 张沛韩琳孙莎莎杜萌
Owner LUOYANG NORMAL UNIV
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