Rhodium-rhenium alloy for anti-inflammation and photothermal therapy as well as preparation method and application of rhodium-rhenium alloy

A photothermal therapy, rhenium alloy technology, applied in the field of nanomaterials, can solve the problem of low activity of rhodium-based catalysts, and achieve the effects of being beneficial to clinical use, good dispersibility and stability, and strong catalytic activity

Active Publication Date: 2022-03-04
HEFEI UNIV OF TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Rhodium (Rhodium, Rh) is a silver-white, hard and rare precious metal, rhodium nanoparticles have good light-to-heat conversion performance, however, it has been reported that compared with platinum or palladium-based catalysts, the activity of rhodium-based catalysts is low, Therefore, it is meaningful to use the intermetallic electronic effect to improve the catalytic effect of rhodium by forming an alloy.

Method used

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  • Rhodium-rhenium alloy for anti-inflammation and photothermal therapy as well as preparation method and application of rhodium-rhenium alloy
  • Rhodium-rhenium alloy for anti-inflammation and photothermal therapy as well as preparation method and application of rhodium-rhenium alloy
  • Rhodium-rhenium alloy for anti-inflammation and photothermal therapy as well as preparation method and application of rhodium-rhenium alloy

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Embodiment 1

[0031] The present embodiment prepares rhodium-rhenium alloy as follows:

[0032] (1) Weigh 42.9 mg of ammonium perrhenate, 10.2 mg of rhodium chloride trihydrate and 16 mg of mercaptopolyethylene glycol and dissolve them in 2 mL of deionized water, mix and stir for 20 minutes to obtain solution A.

[0033] (2) Weigh 75 mg of sodium borohydride and dissolve it in 2.5 mL of deionized water, pre-cool at 4°C to obtain solution B.

[0034] (3) Add solution B to solution A, and stir for 2 hours at room temperature.

[0035] (4) The obtained product is subjected to centrifugation at a centrifugal speed of 9500 rpm and a centrifugation time of 30 minutes to obtain a rhodium-rhenium alloy.

[0036] figure 1 This is the transmission electron microscope image of the rhodium-rhenium alloy obtained in this example. It can be seen that the particle size of the nanoparticles is relatively small, 25-30nm.

[0037] figure 2 It is the visible-near-infrared absorption spectrogram of the rh...

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Abstract

The invention discloses a rhodium-rhenium alloy for anti-inflammation and photothermal therapy and a preparation method and application thereof, the rhodium-rhenium alloy comprises stabilizer modified rhodium-rhenium nanoparticles, and the size of the rhodium-rhenium nanoparticles is 25-30nm. The rhodium-rhenium alloy has the characteristic of removing active oxygen in vivo, can catalytically convert active oxygen molecules such as hydrogen peroxide (H2O2), superoxide anions (O2-) and hydroxyl radicals (. OH) in vivo into water molecules (H2O) and oxygen (O2), reduces the level of the active oxygen in vivo so as to reduce expression of inflammatory factors such as tumor necrosis factors (TNF-alpha) in vivo, and is used for diminishing inflammation; meanwhile, the rhodium-rhenium alloy has strong near-infrared absorption, so that the rhodium-rhenium alloy can be used for photo-thermal treatment, and non-inflammatory photo-thermal treatment of cancers is realized.

Description

technical field [0001] The invention belongs to the technical field of nanometer materials, and in particular relates to a rhodium-rhenium alloy used for anti-inflammatory and photothermal therapy and a preparation method thereof. Background technique [0002] Cancer is one of the major diseases that seriously threaten human health. Currently, there are three main means of clinical treatment of cancer: surgical resection, radiotherapy and chemotherapy. However, these three treatment techniques currently have certain limitations in clinical practice, which reduces the final cancer treatment effect. Therefore, the development of new cancer treatment technologies can make up for the deficiencies of current clinical treatment technologies, and is expected to improve the survival period and quality of life of cancer patients. As an emerging tumor thermal ablation technique, near-infrared light-mediated photothermal therapy has recently attracted great attention due to its non-i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K33/24A61K9/51A61K47/20A61P35/00A61P29/00B82Y5/00B82Y40/00B22F1/102B22F9/24
CPCA61K41/0052A61K33/24A61K9/5146A61P35/00A61P29/00B82Y5/00B82Y40/00B22F9/24Y02A50/30
Inventor 查正宝马鸿娜缪昭华
Owner HEFEI UNIV OF TECH
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