Preparation method and application of titanium tricarbide-bismuth sulfide nano composite material

A nanocomposite material, bismuth sulfide technology, applied in the field of tumor near-infrared light therapy, can solve the problems of low sensitivity and specificity, lack of targeting, etc., to prolong separation time, increase ROS generation, and good biocompatibility and targeted effects

Active Publication Date: 2022-03-29
HARBIN MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to solve the problem of lack of targeting and low sensitivity and specificity in tumor surgical resection, radiotherapy and chemotherapy methods, and at the same time to explore a kind of nanomaterials that take into account both diagnosis and treatment, high efficiency and safety, for tumor patients Formulate a more individualized and precise diagnosis and treatment plan, and provide the preparation method and application of titanium three carbon two-bismuth sulfide nanocomposites

Method used

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  • Preparation method and application of titanium tricarbide-bismuth sulfide nano composite material
  • Preparation method and application of titanium tricarbide-bismuth sulfide nano composite material
  • Preparation method and application of titanium tricarbide-bismuth sulfide nano composite material

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specific Embodiment approach 1

[0018] Specific embodiment one: the preparation method of titanium three carbon two-bismuth sulfide nanocomposite of the present embodiment, carry out according to the following steps:

[0019] Firstly, the titanium trialuminum carbon 2 is etched, and after the etching treatment, the stripping treatment is carried out; then, the oil-soluble titanium trialuminum carbon di-bismuth sulfide nanocomposite is prepared by hydrothermal synthesis reaction using the stripped titanium trialuminum carbon 2 as the substrate. materials, and then transform the oil-soluble titanium three carbon two-bismuth sulfide nanocomposites into water-soluble titanium three carbon two-bismuth sulfide nanocomposites, and finally the water-soluble titanium three carbon two-bismuth sulfide nanocomposites are subjected to mPEG-2K -NH 2 Coating and TPP modification to obtain titanium three carbon two - bismuth sulfide nanocomposite material.

specific Embodiment approach 2

[0020] Specific embodiment two: the difference between this embodiment and specific embodiment one is: the specific steps of etching titanium three aluminum carbon two are as follows: adding titanium three aluminum carbon two powder in the HCl-LiF mixed solution, at 35 ~ Stir magnetically for 48-72 hours at a temperature of 38°C, then repeatedly centrifuge and wash with deionized water and absolute ethanol until the pH is 6-7, and obtain the etched titanium trialuminum carbon two, the quality of the titanium three aluminum carbon two powders and The volume ratio of the HCl-LiF mixed solution was 1 g:5 mL, the concentration of HCl in the HCl-LiF mixed solution was 9 mol / L, and the concentration of LiF was 100 g / L.

[0021] Other steps are the same as in the first embodiment.

specific Embodiment approach 3

[0022] Specific embodiment three: the difference between this embodiment and specific embodiment one or two is: the specific steps of stripping the etched titanium trialuminum carbon two are as follows: put the etched titanium trialuminum carbon two into tetrapropylene In the base ammonium hydroxide solution, stir magnetically at room temperature (23-25°C) for 48-72 hours to obtain the stripped titanium trialuminum carbon two, the quality of the etched titanium trialuminum carbon two and tetrapropyl ammonium hydroxide The volume ratio of the solution is 1 g: 5 mL.

[0023] Other steps are the same as those in Embodiment 1 or 2.

[0024] In Embodiments 2 and 3, Ti3Al2C2 is etched and stripped to obtain Ti3C2 nanosheets, which enhances its electrical conductivity and prolongs the electron-hole ratio of nanocomposites under near-infrared light irradiation. separation time.

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Abstract

The invention discloses a preparation method and application of a titanium tricarbide-bismuth sulfide nano composite material, and relates to the technical field of tumor near-infrared light therapy. The objective of the invention is to solve the problems of lack of targeting, low sensitivity and low specificity in tumor operation excision, radiotherapy and chemotherapy methods. The method comprises the following steps: firstly, carrying out etching treatment on titanium, aluminum and carbon 2, and then carrying out stripping treatment; then taking titanium tri-aluminum-carbon 2 subjected to stripping treatment as a substrate, preparing an oil-soluble titanium tri-carbon 2-bismuth sulfide nano composite material through a hydrothermal synthesis reaction, and then converting the oil-soluble titanium tri-carbon 2-bismuth sulfide nano composite material into a water-soluble titanium tri-carbon 2-bismuth sulfide nano composite material. And finally, sequentially carrying out methoxy polyethylene glycol amine coating and (3-propyl carboxyl) triphenylphosphonium bromide modification on the water-soluble titanium tri-carbon disulfide-bismuth sulfide nano composite material, so as to obtain the titanium tri-carbon disulfide-bismuth sulfide nano composite material. According to the preparation method and application of the titanium tricarbide-bismuth sulfide nano composite material, the titanium tricarbide-bismuth sulfide nano composite material can be obtained.

Description

technical field [0001] The invention relates to the technical field of near-infrared light therapy for tumors, in particular to a preparation method and application of a titanium-three-carbon-two-based nanocomposite material for near-infrared light therapy for tumors. Background technique [0002] Tumor is a major disease that threatens public health with high morbidity and mortality. In recent years, there are about 19 million new cancer cases and nearly 10 million deaths worldwide every year. At the same time, the current tumor surgical resection and radiotherapy and chemotherapy methods lack targeting, and the sensitivity and specificity are not high. Therefore, searching for a high-efficiency and safe nanomaterial that takes into account both diagnosis and treatment, and formulating a more individualized and precise diagnosis and treatment plan for cancer patients is a current research hotspot in cancer treatment, and it also has broad clinical application prospects. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01G29/00C01B32/921A61K41/00A61K47/24A61P35/00A61K49/04A61K49/22B82Y5/00B82Y30/00B82Y40/00
CPCC01G29/00C01B32/921A61K41/0052A61K41/0057A61K47/24A61P35/00A61K49/04A61K49/22B82Y5/00B82Y30/00B82Y40/00C01P2004/80C01P2004/16C01P2004/20C01P2004/03C01P2004/04C01P2002/72C01P2006/60A61K2300/00
Inventor 温朝辉姜涵文孙京先孙冉刘倩韩旭郭阳卢晓晴孙然然
Owner HARBIN MEDICAL UNIVERSITY
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