Synthesis method of 4-tert-butyl cyclohexyl acetic acid

Abstract

The invention discloses a synthesis method of 4-tert-butyl cyclohexyl acetic acid, which comprises the following steps: dissolving 4-tert-butyl phenylacetic acid in a solvent, adding a catalyst into the solvent, carrying out high-pressure catalytic hydrogenation reaction, after the reaction is finished, filtering out the catalyst from reaction liquid, desolventizing and concentrating, adding concentrated liquid into water to separate out solid, centrifuging, and drying to obtain the 4-tert-butyl cyclohexyl acetic acid. The refined 4-tert-butyl cyclohexyl acetic acid is obtained. According to the synthesis method provided by the invention, 4-tert-butylphenylacetic acid is adopted as a raw material, the raw material is cheap and easy to obtain, a target product can be obtained through a one-step catalytic hydrogenation reaction, the synthesis process is efficient and simple, the reaction steps are short, the production cost is relatively low, the product yield is high, the product purity is high, and ions harmful to subsequent coupling reaction are not contained; the method has obvious advantages on subsequent synthesis of buparvaquone. In the whole production process, reaction conditions are mild, safe and environment-friendly, equipment conditions are easy to meet, and industrial production is facilitated.

Description

technical field [0001] The invention relates to the technical field of synthesis of pharmaceutical intermediates, in particular to a synthesis method of 4-tert-butylcyclohexylacetic acid. Background technique [0002] Theilerisis is a general term for diseases caused by various scorch worms of the genus Theileketaylus parasitizing cattle, sheep and other wild animals, among which bovine annulus is the most common. Bovine theileriasis is a bovine blood protozoan disease caused by Theileria annulus, which has the characteristics of wide prevalence, high morbidity and mortality. After the pathogen is transmitted to cattle by ticks, it parasitizes in macrophages, lymphocytes, and red blood cells, and then causes a disease characterized by high fever, anemia, emaciation, and swelling of lymph nodes on the body surface, which in turn leads to the death of cattle. [0003] Bupavaquinone is currently a very effective drug for the treatment of bovine theilesisis. It competitively in...

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Problems solved by technology

[0010] This method obtains 4-tert-butylcyclohexanoic acid through four-step reaction, and the main defect that this method exists is: produce a large amount of phosphorus-containing waste water in the reaction process, environmental protection pressure is big; Often contain trace NaCl in the gained product, and sodium chloride is very easy to make Catalyst AgNO in subsequent coupling reactions 3 Inactivation; control experiments show that adding 0.05eq.NaCl to the reaction can make the reaction completely impossible

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