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Application of periplaneta americana extract in preparation of cerebral apoplexy recovery product

A technique of extracting Periplaneta americana, applied in the field of medicine, to achieve the effect of improving neuromotor dysfunction, promoting nerve regeneration or repair, and promoting proliferation

Pending Publication Date: 2022-04-12
SOUTHWEST UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there have been many studies on brain remodeling drugs in recent years, few of them have been successfully marketed and used clinically.

Method used

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  • Application of periplaneta americana extract in preparation of cerebral apoplexy recovery product
  • Application of periplaneta americana extract in preparation of cerebral apoplexy recovery product
  • Application of periplaneta americana extract in preparation of cerebral apoplexy recovery product

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Experimental program
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Effect test

preparation example Construction

[0031] The preparation method of Periplaneta americana ethyl acetate extract, described method is as follows:

[0032] The dry powder of Periplaneta americana can be roughly extracted by percolation, ultrasonication or reflux to obtain the total extract of Periplaneta americana;

[0033] (1) Roughly extracting the dry powder of Periplaneta americana by means of percolation, ultrasonication or reflux to obtain the total extract of Periplaneta americana;

[0034] (2) Suspend the total extract of Periplaneta americana obtained in step (1) with water to obtain a suspension, which is first extracted with a low-polarity organic solvent, then extracted with ethyl acetate, and collected Ethyl acetate extract, after the ethyl acetate extract is concentrated and freeze-dried, the ethyl acetate extract is obtained.

[0035] Preferably, in step (1), when the dry powder of the Periplaneta americana is roughly extracted by means of percolation, ultrasound or reflux, the dry powder of the P...

Embodiment 1

[0043] The preparation of embodiment 1 American cockroach extract

[0044] Take 1 kg of Periplaneta americana medicinal materials, dry them at 50°C, soak them in 3 times the volume of 55% ethanol at room temperature overnight (more than 10 hours); start diafiltration, continue to add 10 times the volume of 55% ethanol to start diafiltration, collect the filtrate, evaporate Ethanol, concentrated under reduced pressure at 50°C to obtain an extract with a density of 1.1, and spray-dried at 50°C to obtain an extract of Periplaneta americana.

[0045]Among them, the main components of Periplaneta americana include alkaloids, isocoumarins, phenols, flavonoids and steroids, organic acids, peptides, amino acids, nucleosides, sugars, pheromones, Grease, etc.

[0046] More specifically, the main components in Periplaneta americana are peptides (neuropeptides: pharyngeal side body inhibiting neuropeptides Pea-allatostatin1, Pea-allatostatin2, Pea-allatostatin3, Pea-allatostatin4, Pea-al...

Embodiment 2

[0050] Effects of percolation extract of Periplaneta americana on neuromotor function in stroke rats.

[0051] Two models of rat permanent cerebral ischemia (pMCAO) and cerebral ischemia-reperfusion (tMCAO) were established by suture method, and the sham operation group (Sham), model control group (tMCAO / pMCAO) and Periplaneta americana infiltration group were respectively set up. Roll extract group (tMCAO+PA / pMCAO+PA, 60mg / kg), intragastric administration after modeling, neurological function score (mNSS score) was carried out on the 1st, 3rd, 7th, 14th, 21st day of administration, Such as figure 1 As shown, the results showed that compared with the model control group, the mNSS score of the administration group on the 7th, 14th, and 21st days was significantly reduced, indicating that the neuromotor dysfunction of the rats was improved. At the same time, cylinder test was used to evaluate the asymmetry of forelimb use in rats with cerebral ischemia. The results showed that...

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Abstract

The invention discloses an application of a periplaneta americana extract in preparation of a product with at least one of the following functions 1, 2, 3, 4, 5, 6, 7 and 8: 1, promoting nerve regeneration; 2, nerve injury repair is promoted; 3, the neuromotor dysfunction is improved; 4, promoting proliferation of neural stem cells; 5, promoting neural stem cell differentiation; 6, promoting differentiation and maturation of neural stem cells; 7, post-stroke recovery is promoted; and 8, promoting angiogenesis. Through the periplaneta americana extract, expression of nerve regeneration related cytokines is adjusted, nerve regeneration related signal channels are regulated and controlled, nerve regeneration and post-stroke repair are promoted, and the existing technical problems of promoting post-stroke brain remodeling and nerve function recovery are solved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application and medicine of Periplaneta americana extract in products for repairing nerve damage. Background technique [0002] Stroke is defined as interruption of blood supply to the brain due to a blood clot or external embolism, or rupture of a blood vessel, resulting in neurological damage to the brain. It remains the second leading cause of death in the world and the first in China, affecting nearly 20 million people each year. However, the current treatment methods are very limited. The most effective treatment method is to take thrombolytic therapy in time, and use thrombolytic agents in the acute stage of ischemic stroke, such as tissue plasminogen activator (t-PA), or Use surgical operations to remove blood clots (thrombus) mechanically, restore blood recanalization and oxygen supply in the ischemic area in time, and save the ischemic penumbra. Howeve...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61P9/10A61P25/00A23L33/10
Inventor 齐红艺李莉饶江燕
Owner SOUTHWEST UNIVERSITY
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