3 results about "Neuronal stem cell" patented technology

This invention discloses an injectable hydrogel for long-term sustained release of NGF and CNTF, its preparation method, and its application in visual system diseases. The bioactive factor sustained-release hydrogel of this invention comprises a hydrogel matrix and bioactive factor microspheres loaded on the matrix; the raw materials for preparing the hydrogel matrix include chitosan, type II collagen, and hyaluronic acid; the bioactive factor microspheres comprise an inner core and a capsule wall, the inner core being a bioactive factor selected from one or both of ciliary neurotrophic factor and nerve growth factor, and the capsule wall being a polylactic acid-glycolic acid copolymer. This hydrogel can achieve long-term stable release of NTF, activating endogenous neural stem cells in the retina to generate new retinal ganglion cells. It exhibits high safety, good injectability, and a long sustained-release period, and can be used to prepare drugs for treating visual system diseases such as glaucoma, optic nerve damage, and macular degeneration.

An injectable, self-healing hydrogel, its preparation method, and its applications. This invention belongs to the field of biomedical engineering and neural regeneration, specifically relating to a hydrogel, its preparation method, and its applications. This invention provides an injectable, self-healing hydrogel for carrying neural stem cells based on Schiff base crosslinking. This hydrogel achieves self-healing and injectability through dynamic Schiff base bonds. A reversible imine bond crosslinking structure is formed through the Schiff base reaction between amino and aldehyde groups, exhibiting good biocompatibility and structural stability. The surface of biological tissue is rich in amino and hydroxyl groups, which can react again with the aldehyde groups in the OHA to form a dynamic covalent crosslinking network. Through interfacial Schiff base bonding, electrostatic attraction, and hydrogen bonding, this hydrogel can achieve strong wet adhesion to biological tissue and form a stable scaffold at the site of brain injury. Simultaneously, the nanospheres in the system can achieve sustained release of growth factors, effectively promoting the survival, proliferation, and differentiation of neural stem cells, ultimately achieving precise repair and functional recovery of neural tissue.

The application provides application of barium titanate-gold composite nanoparticles in promoting proliferation and / or differentiation of neural stem cells, and belongs to the technical field of medicines. The barium titanate-gold composite nanoparticles have a core-shell structure, and comprise a barium titanate nano core and a gold shell layer wrapped on the surface of the barium titanate nano core. The barium titanate-gold composite nanoparticles can generate weak current stimulation under near-infrared light stimulation to promote proliferation and differentiation of neural stem cells, and can especially promote differentiation of neural stem cells into mature neurons.