Embolism microsphere capable of slowly releasing medicine and preparation method of embolism microsphere

A slow-release drug and microsphere technology, applied in the field of medical materials, can solve the problems of inability to select the desired drug, limit the use of particles, etc., and achieve the effects of good drug loading speed, fast drug loading rate, and good drug loading capacity.

Active Publication Date: 2022-04-12
SHANGHAI HUIHE HEALTHCARE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the drug needs to be added during the preparation of the microparticles, which puts forward high requirements for the stability of the drug and the microparticles, and it is impossible to flexibly select the required drug after loading the drug, which limits the use of the microparticles.

Method used

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  • Embolism microsphere capable of slowly releasing medicine and preparation method of embolism microsphere
  • Embolism microsphere capable of slowly releasing medicine and preparation method of embolism microsphere
  • Embolism microsphere capable of slowly releasing medicine and preparation method of embolism microsphere

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] This embodiment provides a method for preparing polyvinyl alcohol embolic microspheres capable of sustained drug release by using N-(2,2-dimethoxyethyl)-benzamide, which specifically includes the following steps:

[0068] S1. Preparation of polyvinyl alcohol embolization microspheres:

[0069] S11. Add 60 g of polyvinyl alcohol with a weight average molecular weight of 67,000 into 400 mL of purified water, and dissolve completely at 90° C. Then add 0.9g of N-(2,2-dimethoxyethyl)-2-acrylamide and 35mL of 37.5wt% concentrated hydrochloric acid, and react at 30°C for 6h. After the reaction, the pH of the reaction system was adjusted to 7.5 with 2mol / L sodium hydroxide solution. Finally, the solution was concentrated to a viscosity equal to 1800 cps to obtain a microsphere intermediate.

[0070] S12. 15g of the above-mentioned microsphere intermediate, 1.7g of 2-acrylamide-2-methylpropanesulfonic acid sodium salt and 0.45g of potassium persulfate were completely dissolved...

Embodiment 2

[0074] The present embodiment provides a kind of method that prepares the chitosan embolization microsphere that can release medicine with benzoyl chloride, specifically comprises the following steps:

[0075] S1. Preparation of Chitosan Embolization Microspheres:

[0076] S11. Take 15g of chitosan with a weight average molecular weight of about 100,000, add it to 50g of water, heat to 95°C, stir for 3 hours to dissolve completely, add 0.55g of N-acrylamido diethyl acetal and 2mL of concentrated sulfuric acid, 25 ℃ reaction 5h. After the reaction, the pH of the reaction system was adjusted to 7.2 with 0.5 mol / L sodium hydroxide solution. Finally, the solution was concentrated to a viscosity equal to 1800 cps to obtain a microsphere intermediate.

[0077] S12. Weigh 1.6 g of potassium 3-sulfopropylacrylate and 0.86 g of potassium persulfate, dissolve them completely in 10 mL of deionized water, and add 30 g of the above-mentioned microsphere intermediate. Add 300 mL of ethyl...

Embodiment 3

[0081] This embodiment provides a method for preparing sodium hyaluronate embolic microspheres capable of sustained release of drugs by using benzaldehyde, which specifically includes the following steps:

[0082] S1. Preparation of sodium hyaluronate embolization microspheres:

[0083] S11. Take 20g of sodium hyaluronate with a weight-average molecular weight of 140,000, add it to 50g of water, heat to 80°C, stir for 2 hours to dissolve completely, add 0.3g of N-acrylamidoacetaldehyde and 8mL of 37.5wt% concentrated hydrochloric acid, and heat at 30°C Reaction 3h. After the reaction, the pH of the reaction system was adjusted to 7.3 with 0.5 mol / L sodium hydroxide solution. Finally, the solution was concentrated to a viscosity equal to 2000 cps to obtain a microsphere intermediate.

[0084] S12. Dissolve 20 g of the above-mentioned microsphere intermediate, 1.5 g of sodium acrylate and 0.2 g of sodium persulfate in 20 mL of deionized water. Add 180 mL of soybean oil and 1....

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Abstract

The invention provides an embolism microsphere capable of slowly releasing medicine and a preparation method of the embolism microsphere, and belongs to the technical field of medical materials. Molecules capable of slowly releasing drugs are connected to a main chain of the polyhydroxy polymer through an acetal structure or an ester bond structure or copolymerized in a macromolecular network of the microspheres through double bonds. The embolism microsphere capable of slowly releasing the medicine, prepared by the invention, has good medicine loading speed and medicine loading capacity, has the capability of slowly releasing the medicine, and is relatively long in release time, relatively simple in preparation method and mild in reaction condition.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to an embolic microsphere capable of sustained drug release and a preparation method thereof. Background technique [0002] Transarterial chemoembolization (TACE) is a widely used standard treatment for patients with unresectable hepatocellular carcinoma, combining the therapeutic effects of peripheral arterial occlusion with local administration of chemotherapy drugs, delivering chemotherapy drugs in a targeted and controlled manner . Choose the appropriate embolic agent and combine it with chemotherapeutic drugs, and deliver it intravascularly to a specific site in the body for embolization, resulting in strong cytotoxicity and ischemia. Drug-loaded embolic microspheres are currently the latest type of embolic agent, which can provide higher doses of chemotherapy drugs locally while embolizing tumor blood supply, and have the advantages of lower systemic toxicity and su...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/06A61L24/00A61L24/08
Inventor 张雪非苏艺璇
Owner SHANGHAI HUIHE HEALTHCARE TECH CO LTD
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