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Traditional Chinese medicine composition, preparation method thereof and oral preparation containing traditional Chinese medicine composition

A technology of composition and oral preparation, applied in the field of traditional Chinese medicine, can solve problems such as slow effect, liver lobule damage, structural change, etc., and achieve the effects of short course of treatment, less toxic and side effects, and fast onset of effect.

Pending Publication Date: 2022-05-13
SICHUAN UNIVERSITY OF SCIENCE AND ENGINEERING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Hyperlipidemia is generally concentrated among elderly patients. The elderly's blood lipids are higher than the normal range, and they are prone to form such diseases. Hyperlipidemia includes hypercholesterolemia, hypertriglyceridemia and complex hyperlipidemia Hyperlipidemia can easily lead to high blood pressure. Hyperlipidemia can cause atherosclerosis in the human body, leading to myocardial dysfunction and coronary heart disease. When the human body forms atherosclerosis due to long-term high blood lipids, it will cause coronary artery The blood flow becomes smaller, the blood vessel cavity narrows, and the blood injection volume of the myocardium will also decrease, resulting in myocardial ischemia, angina pectoris, and coronary heart disease; high blood lipids can lead to liver function damage, and long-term high blood lipids can lead to fatty liver After hepatic atherosclerosis is damaged, the hepatic lobule is also damaged, which leads to structural changes and damage to liver function; hyperlipidemia is easy to form vascular sclerosis, after the formation of atherosclerosis, a large amount of lipids and proteins in the plasma Deposits in the medium, reduce the speed of blood flow, and become rancid through oxidation, deposit on the arterial endothelium, adhere to the blood vessel wall for a long time, damage the arterial blood vessel skin, and cause arteriosclerosis
[0006] Currently, the main treatment methods for hypertension and hyperlipidemia include exercise therapy, diet therapy, traditional Chinese medicine conditioning, and drug therapy. However, exercise therapy, diet therapy, and traditional Chinese medicine conditioning are slow to take effect. Antihypertensive drugs are effective, but most of them have certain side effects, and have a certain degree of damage to the heart, kidney and other organs

Method used

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  • Traditional Chinese medicine composition, preparation method thereof and oral preparation containing traditional Chinese medicine composition
  • Traditional Chinese medicine composition, preparation method thereof and oral preparation containing traditional Chinese medicine composition
  • Traditional Chinese medicine composition, preparation method thereof and oral preparation containing traditional Chinese medicine composition

Examples

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Effect test

Embodiment 1

[0037] The preparation process of Chinese medicine composition is as follows:

[0038] Step 1: Take 1000g of dried Jianserum, wash and remove impurities, crush it and pass it through a 20-mesh sieve, and use an acidic polar solvent with a volume 20 times the mass of Jianserum at pH = 1.0 to 3.0 to extract 1~ 10h, then extract with 10 times the acidic polar solvent under the same conditions for 0.5-1.5h, combine the extracts, neutralize with dilute lye to make the system pH=6.5-7.5, recover the polar solvent in vacuum to obtain the extract;

[0039] Use an appropriate amount of water to disperse the extract, add ethanol until its volume concentration is 80% to 90%, stir evenly, precipitate for 24 hours, filter, recover ethanol from the filtrate, use chloroform and ethyl acetate to extract the filtered alcohol extract respectively, and then Separating and purifying the extracted components to obtain a series of extracts;

[0040] The specific separation and purification process...

Embodiment 2

[0060] Use the preparation process described in Example 1 to prepare the traditional Chinese medicine composition. The quality of each raw material is as follows according to the ratio of raw material: see serum 1000: cassia seed 100: hawthorn 10: wolfberry 5, and the blood extract in the traditional Chinese medicine composition is the chloroform part The isolated total alkaloids.

Embodiment 3

[0062] Use the preparation process described in Example 1 to prepare the Chinese medicine composition. The quality of each raw material is calculated as follows: see serum 1000: cassia seed 400: hawthorn 200: wolfberry 100, and the blood extract in the Chinese medicine composition is the chloroform part The isolated total alkaloids.

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PUM

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Abstract

The invention discloses a traditional Chinese medicine composition, a preparation method thereof and an oral preparation containing the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw materials in parts by mass: 1000 parts of liparis nervosa, 100-2000 parts of semen cassiae, 10-1000 parts of hawthorn and 5-500 parts of medlar. The traditional Chinese medicine composition provided by the invention has the advantages of high purity of active ingredients, mild action process, quick response and small side effect.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition, a preparation method thereof, and an oral preparation containing the same. Background technique [0002] See serum Liparis nervosa (Thunb) Lindl. It belongs to the genus of Orchidaceae, and it is a ground herb. Yunnan, Guizhou, Sichuan, Guangdong and other places in my country are traditional folk medicinal plants in China. They are cool in nature, bitter in taste, and have pharmacological activities such as blood coagulation, anti-inflammatory, antibacterial, and antioxidant. Hemostasis etc. [0003] At present, domestic and foreign researches on serum are mainly focused on the extraction and analysis of its chemical components and the research on the pharmacological activities of some active components on anti-tumor, anti-bacterial, anti-inflammatory, anti-oxidation, and hemostatic effects; , Clinical treatment ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61K9/20A61K9/48A61P9/12A61P3/06
CPCA61K36/898A61K36/482A61K36/734A61K36/815A61K9/2054A61K9/2059A61K9/4866A61P9/12A61P3/06A61K2236/33A61K2236/53A61K2236/55A61K2300/00
Inventor 李月李妍颢陈良左之利张利
Owner SICHUAN UNIVERSITY OF SCIENCE AND ENGINEERING
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