Gemma agrimoninae suppository and preparation method thereof

Abstract

The invention belongs to the field of pharmaceutical preparations, and particularly relates to a gemma agrimoninae suppository and a preparation method thereof. The gemma agrimoninae suppository is prepared by taking gemma agrimoninae fluid extract as a main medicine component and hydroxypropyl methyl cellulose as a penetration enhancer. The gemma agrimoninae suppository is prepared from gemma agrimoninae fluid extract, hydroxypropyl methyl cellulose, glycerol, gelatin and a preservative, and the weight percentage of the gemma agrimoninae fluid extract to the gemma agrimoninae suppository is as follows: 5.0%-5.5% of the gemma agrimoninae fluid extract, 0.5%-2.5% of the hydroxypropyl methyl cellulose, 60%-70% of the glycerol, 20%-30% of the gelatin, 0.075%-0.1% of the preservative and the balance of water. The weight ratio of the gemma agrimoninae fluid extract to the hydroxypropyl methyl cellulose is 10: (0.5-5). The hydroxypropyl methyl cellulose is one or more selected from the group consisting of HPMC-E5, HPMC-E50, HPMC-K4M, HPMC-K15M and HPMC-K100LV, and the hydroxypropyl methyl cellulose is one or more selected from the group consisting of HPMC-E5, HPMC-E50, HPMC-K4M, HPMC-K15M and HPMC-K100LV. The gemma agrimoninae suppository has the advantages of simple formula, simple preparation process, stable drug release speed, no release degree reduction caused by crystal precipitation after drug release, facilitation of drug permeation, and full play of the curative effect of the drug.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a crane grass bud suppository and a preparation method thereof. Background technique [0002] Crane grass bud is a dry bud with short rhizomes of the Rosaceae plant Agrimonia pilosa Ledeb. As a poorly soluble traditional Chinese medicine, its lipophilicity is high, but its water solubility is very poor, and its dissolution is very little, resulting in a low bioavailability. [0003] Crane grass buds have a very good effect on tapeworms, and its effective monomer, crane grass phenol, can still be used to resist schistosomiasis and human trichomonas vaginalis, trichomoniasis enteritis, and its whole grass can be used for hemostasis and anti-inflammatory. [0004] At present, there is no relevant preparation of Crane grass buds on the market, and the preparation of Crane grass buds into suppositories can more effectively exert its effect, but the preparation o...

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Problems solved by technology

[0004] At present, there is no related crane grass bud preparation on the market. Making crane grass buds into suppositories can exert its effect more effectively, but there are great defects in making crane grass buds into suppositories. Because crane grass buds are insoluble components, conventional After the glycerin is prepared into a suppository, it may reduce the drug absorption due to drug precipitation during the use of the suppository, thereby reducing the efficacy of the drug

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