Sugar-coated tablet and preparation method thereof

A sugar-coated tablet and sugar-coated technology, applied in the field of rhinitis drugs, can solve problems such as bad smell, poor patient experience, cumbersome procedures, etc., and achieve the effects of improved storage validity period, excellent disintegration, and convenient use

Pending Publication Date: 2022-07-05

广东省惠州市中药厂有限公司

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AI-Extracted Technical Summary

Problems solved by technology

[0003] The applicant disclosed a nasal comfort tablet in the invention patent with the application number CN202010124485.0. The nasal comfort tablet includes the following traditional Chinese medicine components in parts by mass: 300-400 parts of cocklebur, 120-160 parts of wild chrysanthemum, goose 200-220 parts of non-grass, 100-120 parts of Angelica dahurica, 100-120 parts of Fangfeng, 200-220 parts of Eclipta, 130-160 parts of white peony, 60-80 parts of Dannanxing, 65-85 parts of licorice, 200 parts of Tribulus terrestris ~220 parts and 0.1~0.5 parts of chlorpheniramine. The nasal comfort t...

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Method used

[0027] The droplet diameter of the sugar-coating solution sprayed during preparation of the sugar-coating is preferably 0.1 to 1000 μm, and the amount of spray can be adjusted according to the size or amount of the embryo so as to involve the entire surface of the embryo. In addition, the temperature of the sugar coating solution ...

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Abstract

The invention relates to a sugar-coated tablet. The sugar-coated tablet comprises a tablet blank and a sugar coating wrapping the tablet blank. The tablet blank is obtained by carrying out shaping and tabletting operation on medicine granules, and the medicine granules are prepared from the following components in parts by weight: 30 to 40 parts of fructus xanthii, 10 to 15 parts of flos chrysanthemi indici, 20 to 22 parts of herba centipedae, 10 to 15 parts of seedless roxburgh rose, 10 to 15 parts of angelica keiskei, 20 to 22 parts of herba ecliptae, 10 to 15 parts of radix paeoniae alba, 6 to 8 parts of microcrystalline cellulose, 2 to 3 parts of magnesium stearate, 1 to 5 parts of sodium citrate and 0.05 to 0.1 part of chlortrimeton. The sugar coating is prepared from the following components in parts by weight: 5 to 10 parts of polyethylene glycol acrylate, 5 to 10 parts of triethylene glycol diacrylate, 5 to 15 parts of isomaltooligosacharide, 2 to 5 parts of lactose, 0.2 to 3 parts of stevioside, 0.5 to 1 part of erythritol, 0.5 to 1 part of mannitol and 5 to 10 parts of xylitol. The invention also relates to a preparation method of the sugar-coated tablet.

Application Domain

Organic active ingredientsPharmaceutical non-active ingredients +5

Technology Topic

MannoseTrisodium citrate +18

Examples

Experimental program(3)
Comparison scheme(3)

Example Embodiment

[0033] Example 1

[0034] This embodiment provides a sugar-coated tablet, which includes a tablet embryo and a sugar coating that wraps the tablet embryo.

[0035] Wherein, the tablet embryo is obtained by performing the shaping and tableting operation of the medicinal granules, and the medicinal granules are composed of the following components by weight: 30 parts of cocklebur, 10 parts of wild chrysanthemum, 20 parts of goose not eating grass, and seedless prickly pear. 10 parts, Ashitaba 10 parts, Eclipta chinensis 20 parts, Paeonia lactiflora 10 parts, Microcrystalline Cellulose 6 parts, Magnesium stearate 2 parts, Sodium citrate 1 part and Chlorpheniramine 0.05 parts.

[0036] Wherein, the sugar coating is composed of the following components by weight: 5 parts of polyethylene glycol acrylate, 5 parts of triethylene glycol diacrylate, 5 parts of isomalt oligosaccharides, 2 parts of lactose, 0.2 parts of stevia, erythrose 0.5 part of alcohol, 0.5 part of mannitol, and 5 parts of xylitol.

[0037] The preparation method of the sugar-coated tablet provided by this embodiment comprises the following steps:

[0038] In step 1, the cocklebur, wild chrysanthemum, goose do not eat grass, seedless prickly pear, ashitaba, Eclipta, and white peony are respectively cleaned and mixed to obtain a mixture, then the mixture is broken into small pieces, and deionized water is added. 0 to 0.3 times, homogenize for 2 to 3 minutes, and place the mixture in a vacuum environment for freeze drying for 12 to 24 hours;

[0039] In step 2, the freeze-dried powder of the mixture obtained in step 1 is pulverized and finely ground through an 80-120 mesh sieve to prepare medicinal powder;

[0040] In step 3, the medicinal powder is soaked in the extraction solvent for not less than 24 hours and then subjected to a decoction operation to obtain an extract, and microcrystalline cellulose, magnesium stearate, sodium citrate and chlorpheniramine are added to the extract, and Mix evenly to obtain liquid medicine;

[0041] Step 4, carry out decompression drying operation to medicinal liquid, obtain pre-drying paste;

[0042] Step 5, performing pulverizing and grinding operations on the pre-dried paste to obtain medicinal granules, and then performing granulation and tableting operations on the medicinal granules to obtain tablet embryos;

[0043] Step 6: Dissolving polyethylene glycol acrylate, triethylene glycol diacrylate, isomaltose oligosaccharide, lactose, stevia, erythritol, mannitol and xylitol in pure water to prepare a sugar coating liquid, using The coating machine sprays the sugar-coating liquid on the surface of the tablet embryo while drying to obtain sugar-coated tablets.

Example Embodiment

[0044] Example 2

[0045] This embodiment provides a sugar-coated tablet, which includes a tablet embryo and a sugar coating that wraps the tablet embryo. The preparation method of the sugar-coated tablet is the same as the preparation method of the sugar-coated tablet provided in Example 1.

[0046] Wherein, the tablet embryo is obtained by performing the shaping and tableting operation of the medicinal granules, and the medicinal granules are composed of the following components by weight: 40 parts of Xanthium japonica, 15 parts of wild chrysanthemum, 22 parts of goose not eating grass, and seedless prickly pear. 15 parts, 15 parts of Ashitaba, 22 parts of Echinacea, 15 parts of white peony, 8 parts of microcrystalline cellulose, 2 to 3 parts of magnesium stearate, 5 parts of sodium citrate and 0.1 part of chlorpheniramine.

[0047] Wherein, the sugar coating is composed of the following components by weight: 10 parts of polyethylene glycol acrylate, 10 parts of triethylene glycol diacrylate, 15 parts of isomalt oligosaccharide, 5 parts of lactose, 3 parts of stevia, erythrose 1 part of alcohol, 1 part of mannitol, and 10 parts of xylitol.

Example Embodiment

[0048] Example 3

[0049] This embodiment provides a sugar-coated tablet, which includes a tablet embryo and a sugar coating that wraps the tablet embryo. The preparation method of the sugar-coated tablet is the same as the preparation method of the sugar-coated tablet provided in Example 1.

[0050] Wherein, the tablet embryo is obtained by performing the shaping and tableting operation of the medicinal granules, and the medicinal granules are composed of the following components by weight: 35 parts of cocklebur, 12 parts of wild chrysanthemum, 21 parts of goose not eating grass, and seedless prickly pear. 14 parts, 12 parts of Ashitaba, 21 parts of Echinacea, 12 parts of white peony, 7 parts of microcrystalline cellulose, 2.5 parts of magnesium stearate, 3 parts of sodium citrate and 0.08 parts of chlorpheniramine.

[0051] Wherein, the sugar coating is composed of the following components by weight: 7 parts of polyethylene glycol acrylate, 8 parts of triethylene glycol diacrylate, 10 parts of isomaltose oligosaccharide, 4 parts of lactose, 1 part of stevia, erythrose 0.7 parts of alcohol, 0.6 parts of mannitol, and 6 parts of xylitol.

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Description & Claims & Application Information

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the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine

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Classification and recommendation of technical efficacy words

Improve physical and chemical properties
Easy to use

Soil heavy metal repairing agent

ActiveCN104560049AReduced activityImprove physical and chemical propertiesAgriculture tools and machinesOrganic fertilisersIonCrop

Owner:湖南神隆海洋生物工程有限公司

Composite soil passivator for reducing contents of cadmium and lead as well as preparation method and application method of composite soil passivator

ActiveCN104193546AImprove physical and chemical propertiesConducive to cultivationFertilizer mixturesCalcium magnesiumSepiolite

Owner:湖南润邦生物工程有限公司

Sugar-coated tablet and preparation method thereof

A sugar-coated tablet and sugar-coated technology, applied in the field of rhinitis drugs, can solve problems such as bad smell, poor patient experience, cumbersome procedures, etc., and achieve the effects of improved storage validity period, excellent disintegration, and convenient use

AI-Extracted Technical Summary

Problems solved by technology

Method used

Abstract

Examples

Example Embodiment

Example Embodiment

Example Embodiment

PUM

Description & Claims & Application Information

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