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Application of kojic acid esterification modified product in preparation of whitening skin care product

A technology for modifying kojic acid esters, which is applied in the preparation of whitening skin care products by kojic acid esterified modified products. High cost and other issues, to achieve the effects of avoiding stinging, good safety, and low production cost

Pending Publication Date: 2022-07-22
广东瑞驰生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the modified kojic acid derivatives have better whitening effect and less side effects than kojic acid, the kojic acid modification method disclosed in the technical scheme is too cumbersome and the production cost is high, which is not conducive to the market at all. to promote

Method used

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  • Application of kojic acid esterification modified product in preparation of whitening skin care product
  • Application of kojic acid esterification modified product in preparation of whitening skin care product
  • Application of kojic acid esterification modified product in preparation of whitening skin care product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] (1) Dissolve 14.2 g of kojic acid (0.1 mol) in DMF solvent, add 240 g of phospholipid polyethylene glycol carboxyl group (0.12 mol), use concentrated sulfuric acid as a catalyst, react at 35-40 ° C overnight, dialyze, freeze-dry to obtain Phospholipid polyethylene glycol-kojic acid;

[0037] (2) Weigh 100 mg of lecithin and 50 mg of cholesterol in a single-necked bottle, add 3 times the volume of chloroform-methanol solution, remove the solvent by rotary evaporation, add 250 mg of phospholipid polyethylene glycol-kojic acid prepared in step (1) and 60 mL of PBS buffer solution (pH=7.4), hydrated at 40°C for 2 hours, sonicated, and extruded 20 times through a polycarbonate membrane with a pore size of 300 nm to obtain a kojic esterification modified product with a kojic acid content of 4.2%.

Embodiment 2

[0039] The preparation method and components are the same as those of Example 1, except that the hydration-completed product is extruded 20 times through a polycarbonate membrane with a pore size of 200 nm to obtain a kojic esterified modified product.

Embodiment 3

[0041]The preparation method and components are the same as those in Example 1, except that the hydration-completed product is extruded 20 times through a polycarbonate membrane with a pore size of 100 nm to obtain a kojic esterified modified product.

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Abstract

The invention discloses a kojic acid esterification modification method which comprises the following steps: (1) carrying out grafting reaction on phospholipid polyethylene glycol carboxyl and kojic acid to obtain phospholipid polyethylene glycol-kojic acid; and (2) taking phospholipid, cholesterol and phospholipid polyethylene glycol-kojic acid as raw materials, adding a hydration solution, hydrating, performing ultrasonic treatment, extruding and passing through a membrane to obtain a product. Compared with free kojic acid, the kojic acid esterification modified product prepared by the method is stable in property, good in transdermal absorption effect and better in whitening effect, and can be used for preparing whitening skin care products such as cosmeceuticals, whitening cream, whitening emulsion, whitening oil and whitening toner.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and in particular relates to the application of a kojic esterification modified product in the preparation of whitening skin care products, and a method for preparing the kojic esterification modified product. Background technique [0002] With the rise of the current face value economy, fair and smooth skin is respected by more and more young groups, and the demand for skin care products related to whitening is increasing day by day. more popular. At present, the mechanism of action of whitening products mainly includes the following three aspects: inhibiting melanin formation, interfering with melanin transfer and accelerating melanin degradation. [0003] It can be seen from the above whitening mechanism that melanin is the biggest obstacle to skin whitening. Melanocytes, also known as dendritic cells, are mainly located in the basal layer of the skin, and their function is to transmit mat...

Claims

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Application Information

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IPC IPC(8): A61K8/86A61K8/63A61K8/55A61K8/49A61K8/14A61Q19/02
CPCA61K8/86A61K8/63A61K8/553A61K8/498A61K8/14A61Q19/02A61K2800/782
Inventor 丁孝平
Owner 广东瑞驰生物科技有限公司
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