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Bionic anticoagulant zwitterionic microgel coating and preparation method thereof

A zwitterion, microgel technology, applied in coating, medical science, surgery, etc., can solve the problems of insufficient stability, low grafting efficiency, complicated preparation process, etc., and achieve excellent anticoagulant performance and simple preparation process. , the effect of good stability

Pending Publication Date: 2022-07-29
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In view of this, the purpose of the present invention is to overcome the shortcomings of existing zwitterionic polymer coatings such as cumbersome preparation process, low grafting efficiency and insufficient stability, and provide a coating with simple preparation process, high density zwitterionic groups and good coating properties. Stable anticoagulant coating and preparation method thereof

Method used

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  • Bionic anticoagulant zwitterionic microgel coating and preparation method thereof
  • Bionic anticoagulant zwitterionic microgel coating and preparation method thereof
  • Bionic anticoagulant zwitterionic microgel coating and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] (1) Weigh 6g of methacryloylethyl sulfobetaine (SBMA), 60mg of potassium persulfate, 1.8g of polyvinylpyrrolidone, 6g of deionized water and 54g of ethanol and added to a 100mL three-necked flask. Stirring was carried out at a speed of 300 rpm under a nitrogen atmosphere, and the reaction temperature was set to 80°C. As the mixture became cloudy, 600 mg of N,N-methylenebisacrylamide and 3 g of 2-aminoethylmethacrylate were slowly added dropwise to the mixed solution. After the dropwise addition, the reaction was continued for 2 hours to obtain a milky white microgel suspension. The resulting microgel suspension was centrifuged at 2000 rpm, washed three times with ethanol, and dried in vacuo to obtain a purified amino-functionalized zwitterionic microgel. like figure 1 shown, the infrared spectra of the prepared amino-functionalized zwitterionic microgels. From the infrared spectrum, it can be seen that the amino-functionalized zwitterionic microgel is at 1640 cm -1 ...

Embodiment 2

[0056] (1) Weigh 4.5 g of methacryloylethyl sulfobetaine (SBMA), 20 mg of ammonium persulfate, 0.9 g of polyvinylpyrrolidone, 15 g of deionized water and 45 g of ethanol into a 100 mL three-necked flask. Stirring was carried out at 300 rpm under nitrogen atmosphere, and the reaction temperature was set at 40°C. As the mixture became cloudy, 100 mg of N,N-methylenebisacrylamide and 2.2 g of 2-aminoethyl methacrylate were slowly added dropwise to the mixed solution. After the dropwise addition, the reaction was continued for 24 hours to obtain a milky white microgel suspension. The resulting microgel suspension was centrifuged at 1000 rpm, washed three times with ethanol, and dried in vacuo to obtain a purified amino-functionalized zwitterionic microgel.

[0057] figure 2 (B) is an SEM of the amino functionalized zwitterionic microgel prepared in Example 2. The SEM images showed that the amino-functionalized zwitterionic microgels were uniform in size and monodispersed spher...

Embodiment 3

[0061] (1) Weigh 6g of methacryloylethylsulfobetaine (SBMA), 20mg of ammonium persulfate, 0.3g of polyvinylpyrrolidone, 6g of deionized water and 54g of ethanol into a 100mL three-necked flask. Stirring was carried out at 300 rpm under nitrogen atmosphere, and the reaction temperature was set at 40°C. As the mixture became cloudy, 300 mg of N,N-methylenebisacrylamide and 0.8 g of N-(3-aminopropyl)methacrylamide were slowly added dropwise to the mixed solution. After the dropwise addition, the reaction was continued for 20 hours to obtain a milky white microgel suspension. The resulting microgel suspension was centrifuged at 7000 rpm, washed three times with ethanol, and vacuum dried to obtain a purified amino-functionalized zwitterionic microgel.

[0062] figure 2 (C) is an SEM of the amino functionalized zwitterionic microgel prepared in Example 3. The SEM images showed that the amino-functionalized zwitterionic microgels were uniform in size and monodispersed spherical p...

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Abstract

The invention discloses a bionic anticoagulant zwitter-ion microgel coating and a preparation method thereof. The coating comprises the following components in percentage by weight: 32.2 to 66.6 percent of amino-functionalized zwitterionic microgel, 26.6 to 64.5 percent of a compound containing a catechol component, and 3.2 to 6.6 percent of a polyamino compound, wherein the content of the amino-functionalized zwitterionic microgel is 32.2 to 66.6 percent of the amino-functionalized zwitterionic microgel. Preparing amino-functionalized zwitterionic microgel through dispersion polymerization; the method comprises the following steps: dispersing purified amino-functionalized zwitterionic microgel, a compound containing a catechol component and a polyamino compound in a Tris-HCl buffer solution with the pH value of 8.5, and preparing a zwitterionic microgel coating through oxidation codeposition; the method is simple in process and mild in condition; the prepared zwitter-ion microgel coating simulates the microstructure of the surface of fish skin, has excellent super-hydrophilicity, stability and anticoagulation performance, and has good application prospects in the field of blood contact medical instruments.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a biomimetic anticoagulant zwitterion microgel coating and a preparation method thereof. Background technique [0002] Implantable medical devices such as heart valves, endovascular stents, joint prostheses, and artificial blood vessels have been widely used in clinical treatment. Although these implants save the lives of patients, they inevitably cause non-specific adhesion of proteins, platelets and cells to their surfaces, thereby causing coagulation and thrombosis, leading to implant failure, and even endangering the patient's life. Currently, preventing nonspecific adsorption of proteins on the surface of medical devices is an effective strategy to inhibit thrombosis. Zwitterionic polymers (such as phosphorylcholine, carboxybetaine, sulfobetaine) are polymers with equal positive and negative charges in the molecule, which can interact with water molecules through electro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/08A61L31/10A61L31/14A61L31/16
CPCA61L31/08A61L31/10A61L31/14A61L31/145A61L31/16A61L2420/02A61L2420/06A61L2300/42A61L2300/606C08L79/02C08L5/08
Inventor 李俊杰姚蒙蒙姚芳莲张宏
Owner TIANJIN UNIV
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