Liniment of levamisole hydrochloride

A technology of levamisole hydrochloride and mixed solvents, which is applied in the field of medicine, can solve the problems of affecting curative effect, animal death, and inability to persist in long-term medication, and achieve the effects of reducing economic burden, convenient use, and low dosage

Inactive Publication Date: 2005-04-20
朱钦文 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Yet existing levamisole hydrochloride preparation product only has a kind of oral tablet, and the side reaction rate of oral administration is generally about 30%, mainly are the gastrointestinal reactions such as nausea, vomiting, gastrointestinal discomfort, abdominal pain and dizziness, headache etc.
Therefore, long-term medication cannot be adhered to, thereby affecting the curative effect
Some people have tried to make levamisole hydrochloride into injections, but there have been many cases of death of animals (dogs) in the animal experiment stage.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0021] Experimental example 1 Transdermal experiment

[0022] The purpose of this experimental example is to determine the chemical composition ratio that can make levamisole hydrochloride as an active ingredient penetrate the skin faster. In this experiment, mouse skin was used instead of human skin.

[0023] (1) The composition of the formulation used for the screening test is shown in Table 1.

[0024] prescription

serial number

Levamisole Hydrochloride

(g)

Isopropanol

(ml)

Propylene Glycol

(ml)

Azone

(ml)

distilled water

1

10

20

10

1

make up to

100ml

2

10

30

20

1

3

10

20

20

3

4

10

30

10

3

[0025] The ratio of each component in the table will be described below. Owing to making up to 100ml with distilled water at last, therefore, f...

experiment example 2

[0043] This experimental example is to study the influence of levamisole hydrochloride liniment of the present invention on the phagocytic function of mouse reticuloendothelial system (RES).

[0044] Fifty ICR mice, half male and half female, weighing 20±2 g, were used and randomly divided into 5 groups, 10 mice in each group. Apply levamisole hydrochloride liniment 0.65, 1.25, 2.5ml / kg on the depilated skin (2×2cm) of the back respectively, vehicle 10ml / kg as a control, take tremella polysaccharide 10ml / kg (1ml contains tremella polysaccharide 20ml) orally as positive sex control. Dosing once a day for 4 days. One hour after the last administration, inject 10ml / kg of colloidal carbon suspension intravenously (the concentration of colloidal carbon suspension is 16mg / ml), and then draw 25ml of blood from the orbital venous plexus with a straw (wetted with heparin in advance) every 3 minutes . 5 times in a row. Then the mice were sacrificed by cervical dislocation, and the w...

experiment example 3

[0049] This experimental example is to study the influence of levamisole hydrochloride of the present invention on the weight of mouse immune organs.

[0050] Fifty male ICR mice with a body weight of 13±1 g were used and randomly divided into 5 groups, 10 in each group. On the depilated skin (2 × 2cm) of the back of the mouse, the smearing concentration is 0.625, 1.25, 2.5ml / kg of levamisole hydrochloride liniment of 100mg / ml (prescription 2 in table 1) respectively, with vehicle 10ml / kg as contrast , In addition, Tremella polysaccharide 10ml / kg (1ml containing Tremella polysaccharide 20mg) was taken orally as a positive control. Dosing was once daily for 6 days. On the next day after the last administration, the rats were sacrificed by bloodletting from the orbit, and the thymus and spleen were dissected, weighed with a precision torsion balance, and the differences among the groups were compared. The results obtained are shown in Table 5.

[0051] group

d...

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PUM

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Abstract

Levamisole hydrochloride liniment, the liniment is dissolved in 10-40 volume % of isopropanol, 5-30 volume % of propylene glycol, 0.5-5 volume % of azone by levamisole hydrochloride at a final concentration of 20-200 mg / ml, and the rest The portion less than 100% by volume is formed in a mixed solvent composed of pure water. The levamisole hydrochloride liniment can be well absorbed by the animal's skin, can obviously improve the immunity of the animal, has low dosage, is convenient to use, and has no toxic and side effects.

Description

technical field [0001] The invention relates to the field of medicine, more specifically, to levamisole hydrochloride liniment. Background technique [0002] The pharmacological basis of levamisole hydrochloride is that it has no effect on the body with normal immune function, but only exerts a significant enhancement effect on the cases with low immune function, so that it can return to normal. It mainly acts on T lymphocytes, induces the differentiation and maturation of early pre-T cells into functional T cells, and restores dysfunctional T cells to normal. At the same time, it can enhance the chemotaxis and phagocytosis of monocytes, activate macrophages and granulocytes Inhibiting factor of cell movement, induces endogenous interferon, thus produces immune function and antiviral efficacy. Moreover, the metabolite of levamisole hydrochloride, omediazole (OMPI), has a stronger immunoregulatory effect than it. In addition to its thymosinoid and cyclic nucleotide regulatio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/429A61K47/10A61K47/22
CPCA61K9/0014A61K31/429A61K47/10A61K47/22A61P11/06A61P35/00A61P37/04
Inventor 朱钦文朱凯甦
Owner 朱钦文
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