Hypotensor composition, prepn. method and application thereof

Abstract

An antihypertensive composition used to prepare the medicine for treating hypertension is prepared from Na2SO3, NaHSO3 and physiological saline through proportionally mixing. Its advantages are quickly taking its high effect on lowering blood pressure, low by-effect and low cost.

Description

1. Technical field [0001] The invention relates to a drug for lowering blood pressure, in particular to a composition with the effect of rapidly lowering blood pressure, a preparation method and application thereof. 2. Background technology [0002] Hypertension is a common disease that endangers public health. The etiology is complex and there are individual factors. Rational medication should be taken according to the condition. At present, there are many kinds of antihypertensive drugs, which can be divided into the following eight categories according to their action sites and mechanisms (see Table 1): (1) diuretic antihypertensive drugs; (2) β-adrenoceptor blocking drugs; (3) Vasodilators; (4) calcium channel blockers; (5) angiotensin-converting enzyme inhibitors; (6) central nervous system and sympathetic nerve inhibitors; (7) enzyme inhibitors; (8) angiotensin II receptors body antagonists. [0003] In the course of hypertension, a sudden or significant increase in ...

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Problems solved by technology

However, in the process of rapid blood pressure reduction, sometimes the adverse reactions of drugs can offset the benefits of blood pressure reduction. For example, hydralazine can reflexively increase heart rate and cardiac output, which can cause palpitations, angina pectoris, and even myocardial infarction.

Another example is sodium nitroprusside (sodium nitroprusside), one of the most commonly used drugs for cardiovascular emergencies. It has strong effects and quick onset, can expand the arterial and venous systems in a balanced manner, and has a definite antihypertensive effect. Decomposition, the second is that long-term use can produce cyanide accumulation, leading to lactic acidosis, and the third is that its intermediate metabolites need to be converted into thiocyanate and then excreted from the kidneys, so it must be used with caution in liver and kidney insufficiency and heart failure

[0004] Table 1 lists common drugs for emergency treatment of hypertension, but each drug has certain side effects

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