Method for preparing multilayer medicine composite degradable biliary tract rack visible under X-ray

An x-ray and drug technology is applied in the field of multi-layer drug composite polymer material bile duct stent and its preparation, which can solve the problems of easy blockage of stent lumen and the like

Inactive Publication Date: 2005-03-02
TSINGHUA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, Ginsberg G et al. reported a degradable biliary stent, but due to biliary infection and g

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0024] 1) Preparation of the main body of the stent: winding filaments of degradable polymer materials with drugs and imaging agents on a mold to form a stent;

[0025] 2) Select a series of polymer materials, the selection methods are as follows:

[0026] a) Use one of polylactic acid, copolymer of lactic acid and glycolic acid, polycaprolactide, polyβ-hydroxybutyrate valerate or polycaprolactone, and select 3 to 10 materials with different molecular weights , the largest molecular weight is 100,000 to 1,000,000 D / mol, and each molecular weight has a difference of 0.1 to 200,000 D / mol.

[0027] b) Select a copolymer of lactic acid and glycolic acid, the molecular weight of the selected material is 50,000 to 500,000; select 3 to 5 kinds of lactic acid monomer molar content, the maximum of which is 50% to 100%, and each content differs by 5% to 20% in turn %;

[0028] c) Choose one of chitosan, chitin, collagen, gelatin natural polymer, and mix it with polyethylene glycol wit...

Embodiment 1

[0036] (1) Add polycaprolactone to chloroform to form a solution with a mass volume concentration of 20% (g / ml), stir and fully dissolve. The molecular weight of PCL used is 300,000. Docetaxel was added into the solution to make the drug molar volume concentration 1 (mol / ml). Stir well.

[0037] (2) The solution is poured into the mold and volatilized at 0°C. Control the film thickness to 0.4mm. Sheets with a width of 2 mm were produced. The polymer sheet is wound on a certain mold and thermosetted at 100°C. The resulting shape is spiral.

[0038] (3) Prepare chloroform solutions of polycaprolactones with different molecular weights, the molecular weights are respectively: 1,000,000, 800,000, and 600,000. The mass volume concentration of the solution is 0.0001 (g / ml). The anti-inflammatory substance dexamethasone is added to make its mass volume concentration 0.2 (g / ml). Sodium iodide was added at a mass volume concentration of 0.2 g / ml, and an antineoplastic drug pacl...

Embodiment 2

[0041] (1) Add polycaprolactone to chloroform to form a solution with a mass volume concentration of 20% (g / ml), stir and fully dissolve. The molecular weight of PCL used is 300,000. Docetaxel was added into the solution to make the drug molar volume concentration 1 (mol / ml). Stir well.

[0042] (2) The solution is poured into the mold and volatilized at 0°C. Control the film thickness to 0.4mm. Sheets with a width of 2 mm were produced. The polymer sheet is wound on a certain mold and thermosetted at 100°C. The resulting shape is spiral.

[0043] (3) Configure chloroform solutions of polylactic acid with different molecular weights, the molecular weights are: 100,000, 99,000, 98,000, 97,000, 96,000, 95,000, 94,000, 93,000, 92,000, and 91,000. The mass volume concentration of the solution is 0.2 (g / ml).

[0044] (4) Dilute the suspension in (3) by 10ml / cm 2 The ratio of spraying and pouring on the sheet in (2) in sequence. After each spraying, air-dry and heat-treat a...

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Abstract

The present invention relates to the preparation of biodegradable, X-ray visible, anti-infectious, antitumor, anti-fibrosis and anti-calculus multi-layer composite medicine composite polymer biliary rack. Several kinds of degradable polymer material are used in preparing the multi-layer rack, and the degradation speed gets faster from inside to outside of the rack cavity. During the degradation, the rack falls down from inside to outside, and the induced gall silt and gallstone fall from the rack to drain into intestinal tract without forming large gallstone to prevent re-stenosis and infection.

Description

technical field [0001] The invention relates to a biodegradable, X-ray-visible, anti-infection, anti-tumor, anti-fibrosis, and anti-calculus bile duct stent of multi-layer drug composite polymer material and a preparation method thereof, belonging to the technical field of bioengineering. Background technique [0002] The internal support drainage tube plays an important role in biliary surgery. Its main function is to fully decompress and drain the repaired and reconstructed bile duct, which is conducive to the normal progress of its healing process. At present, there are two types of support drainage tubes and stents in clinical use in the bile duct: one is T-shaped tube or U-shaped tube, which can only be used for a short time and must be removed by secondary surgery; the other type of memory alloy biliary stent is permanently implanted. , only for malignant biliary obstruction. The recently researched degradable polymer stent has better biocompatibility, and can eventua...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61L31/06A61M29/00A61M31/00
Inventor 崔福斋徐迎新孟波
Owner TSINGHUA UNIV
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