Method for preparing crosslinked chitin-glycan-quaterisation collagen hydrolysate

Abstract

The present invention is crosslinked chitosan-quaternized hydrolyzed collagen preparing process and relates to antibiotic biological material preparation. The crosslinked chitosan-quaternized hydrolyzed collagen is prepared with silkworm pupa chitin and hydrolyzed collagen as material. The preparation process includes mixing two kinds of solution, adding crosslinking agent to perform crosslinking reaction, membrane concentration, regulating pH value, and volumetric or spray drying to produce powder. The present invention can prepare solution or sol product and into the product, various water soluble functional factors, such as skin growth factor, moisture maintaining factor, vitamin, etc. may be added to form multifunctional biological dressing.

Description

1. Technical field [0001] The invention relates to the preparation of antibacterial biological materials, in particular to the preparation method of chitosan-quaternized hydrolyzed collagen 2. Technical background [0002] With the improvement of people's material living standards and the quality and environmental protection requirements of consumer goods, articles with antibacterial functions have emerged as the times require, with broad market prospects and significant economic and social benefits. Chitosan is a natural polycationic polysaccharide, which is obtained from the shells of crustaceans and other invertebrates, as well as the cell walls of algae and fungi. 9 ~10 11 tons, which is the second largest renewable resource after cellulose. Chitosan has excellent broad-spectrum antibacterial properties, and has obvious inhibitory effect on the growth of dozens of bacteria and molds. It has good biocompatibility, non-toxic, non-irritating and non-antigenic properties. ...

AI Technical Summary

Problems solved by technology

However, because chitosan is a chain polymer formed by D-glucose through β-1-4 glycosidic bonds, although it has good film-forming properties and can form a gel, however, due to the basic structural unit of chitosan-amino Glucose is obviously different from the amino acid, the basic unit of protein that makes up the skin. Therefore, the film made of chitosan alone has a weak affinity with the skin, and it is easy to peel off after drying; There are a large number of hydrogen bonds between them, and the hydrogen bond energy is high, so that the linear chitosan molecules are tightly combined. After the film is formed, there are almost no holes, poor air permeability, and high brittleness, so that its antibacterial free amino groups are also shielded in large quantities, making chitosan The antibacterial effect of sugar film is not as good as its solution; due to the tight combination of a large number of hydrogen bonds between linear chitosan molecules, the gel formed by chitosan is dense, with few holes, and cannot accommodate substances with large molecular weight. The addition of active biomacromolecules to glycan gel affects the effect of biological dressings

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