Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Compound red yeast extract medicinal preparation and its application

A technology for extracts and drugs, applied in the field of compound pharmaceutical compositions, can solve problems such as unsatisfactory curative effect and the like

Inactive Publication Date: 2005-08-10
FUKANGREN BIO PHARMA
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] At present, clinically, it is mainly aimed at lowering blood pressure alone, or simply lowering blood lipids, and the curative effect is not ideal.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Compound red yeast extract medicinal preparation and its application
  • Compound red yeast extract medicinal preparation and its application
  • Compound red yeast extract medicinal preparation and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Preparation of Captopril + Red Yeast Extract Ordinary Tablets

[0053] Element

[0054] Red Yeast Extract

[0055] Preparation method: pass through 80-mesh sieve for drug and excipients respectively, mix captopril, red yeast rice extract, lactose, hydroxypropyl cellulose, coach carmellose sodium, micropowder silica gel, magnesium stearate, powder It can be directly compressed into tablets.

Embodiment 2

[0057] Prepare enteric-coated tablets.

[0058] According to Example 1, 1000 common tablets were prepared as tablet cores, which were coated with enteric coating. Enteral solution was prepared as follows:

[0059] prescription:

[0060] 1000 tablets

[0061] Hydroxypropyl methylcellulose phthalate 33.5g Coating polymer

[0062] Ethylcellulose 5.2g Film coating aid

[0063] Ethanol 200ml organic solvent

[0064] Acetone 200ml organic solvent

[0065] Coating with a coating pan

[0066] Operating conditions:

[0067] Coating pan speed 6~7r / min

[0068] Spray Type Airless Spray

[0069] Nozzle size 0.4mm nozzle (60° angle)

[0070] Spray speed 100ml / min

[0071] Liquid pressure 52~80kg / cm 2

[0072] Exhaust velocity 140~160m 3 / min

[0073] Intake air velocity 130~150m 3 / min; 20℃

[0074] 40%~60% relative humidity

[0075] Coating time 45min

[0076] Tablet weight increased by about 5% after coating.

Embodiment 3

[0078] Prepare regular capsules.

[0079] Element

[0080] Preparation method: the drug and auxiliary materials are passed through 80-mesh sieve respectively, and the prescribed amount of fosinopril, red yeast rice extract, microcrystalline cellulose, and sodium carboxymethyl starch are mixed, and mixed with 5% povidone 75% ethanol solution Make soft materials, sieve, dry at 60-70°C, granulate, add talcum powder and mix well, then fill into capsule shells.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A compound medicine containing proportionally the extract of red rice, angiotonin transferase depressent and medical auxiliary. Its application is also disclosed.

Description

Technical field: [0001] The invention relates to a compound pharmaceutical composition composed of two kinds of medicines. The composition contains red yeast extract, an angiotensin-converting enzyme inhibitor, and appropriate amount of pharmaceutically acceptable auxiliary materials. Background technique: [0002] Angiotensin-converting enzyme inhibitors can prevent angiotensin I from being converted into angiotensin II, reduce peripheral vascular resistance, and reduce water and sodium retention by inhibiting aldosterone secretion. It can also dilate peripheral blood vessels by interfering with the degradation of bradykinin. Thereby it has a hypotensive effect. [0003] As a traditional Chinese medicine, red yeast rice is recorded in "Pharmacopoeia of the People's Republic of China" and "Dictionary of Chinese Medicine". Description Red koji, also known as red koji, is prepared by inoculating Monascus on rice and fermenting it. In recent years, relevant scholars at home ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K45/06A61P9/12
Inventor 鄂滟蔡金巧
Owner FUKANGREN BIO PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com