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Qiaoruisu coleus dripping pill and its preparing method

A technology of Su dripping pills and sheath stamens, applied in the field of pharmaceutical preparations, to achieve the effects of increased bioavailability, increased active ingredient content, and increased dissolution rate

Inactive Publication Date: 2005-10-19
KUNMING XINGZHONG PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the pharmaceutical preparations with a single traditional Chinese medicine Coleus sol as the only effective medicinal ingredient

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Weigh the whole plant of Coleus spp. and crush it, add 8 times the amount of 85% ethanol to reflux three times, each time for 2 hours. Combine the ethanol extracts, concentrate under reduced pressure to no alcohol, add 60°C hot water (so that 1ml contains 1g crude drug), keep the temperature at 60°C, stir for 30 minutes, filter with filter cloth, add ammonia water to the filtrate to make PH = 7, let it cool . Extract four times with chloroform, combine the extracts, add 0.5% (according to crude drug) activated carbon, stir for 30 minutes, filter, and recover chloroform from the filtrate. An appropriate amount of silica gel G is added to the concentrated solution to make it absorb and disperse, and then dry to obtain the extract. The extract was placed on an alumina column and eluted with acetone:petroleum ether (2:8) to collect effective fractions and recover the solvent. Take 1 part of the active part of the extract, add 1 part of polyethylene glycol 4000, and make d...

Embodiment 2

[0041] Take 8 parts of the extract, add 1.5 parts of polyethylene glycol 6000, and 0.5 parts of stearic acid, and make drop pills through a conventional process.

Embodiment 3

[0043] Take 7 parts of the extract, add 2 parts of beeswax and 1 part of stearic acid, and make drop pills by conventional technology.

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PUM

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Abstract

The present invention relates to a kind of medicine preparation with function of relieving spasm of smooth muscle in respiratory tract, and is especially one kind of dripping pill preparation with single effective medicine component and its preparation. The Qiaoruisu coleus dripping pill of the present invention is oral medicine preparation prepared with Qiaoruisu coleus extractive and medicinal supplementary material. The Qiaoruisu coleus dripping pill of the present invention has high effective component content, high bioavailability, increased medicine leaching speed, raised medicine absorption speed and high curative effect.

Description

technical field [0001] The invention relates to a pharmaceutical preparation which has an antispasmodic effect on airway smooth muscle, especially a drop pill preparation which uses a single drug as an effective active ingredient and a preparation method thereof. technical background [0002] Chinese Patent Application No. 96122911.X discloses a "Chinese medicine granule for treating bronchial asthma and its preparation method". The traditional Chinese medicine compound granule of type chronic bronchitis is made with following raw material ratio (consumption is weight part) and method: Coleus 1000-3000, Peucedanum 100-250, Radix Glycyrrhizae 25-65; The raw material of above-mentioned ratio is used 80-90% ethanol reflux extraction, recovery of ethanol to obtain extract, followed by extract: soluble starch ratio of 1:1, extract: sweetener ratio of 1:2-3, extract: dextrin 1:0.3 Add soluble starch, sweetener and dextrin at a ratio of -0.5, powder and sieve. It has the characte...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61P11/00
Inventor 张荣球孔令义王公华左光云
Owner KUNMING XINGZHONG PHARMACEUTICAL CO LTD
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