Method for preparing biological filler for injectable soft tissue

A filling material and soft tissue technology, applied in the field of injectable soft tissue biological filling material and its preparation, can solve the problems of low antigenicity, high price, and difficulty in popularization, and achieve the effects of easy industrial production, wide sources, and cost reduction.

Inactive Publication Date: 2006-01-11
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the rapid degradation of this product, the filling effect is not good, and it needs multiple continuous injections, and the rebound rate is high; TM "Represented by micronized human acellular dermal matrix, this product completely retains the morphological structure and composition of the dermal extracellular matrix due to the removal of cellular components that trigger host rejection, with good mechanical properties and low antigenicity. Enlarging soft tissue and stimulating collagen hyperplasia, but the material has a certain degree of absorbency, and the raw material is human cadaver skin, the source is very limited, the price is expensive, and it is difficult to promote in a large area

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1: The preparation method of the injectable soft tissue biofilling material of the present invention, its steps are as follows, by weight with pigskin weight as 100 parts, the reaction is carried out in a stainless steel drum:

[0022] 1. Degreasing: Take fresh piglet skin, remove the foreign matter on the skin, peel off the subcutaneous fat, and degrease, with 150 parts of water, 1.7 parts of soda ash, at a temperature of 37-38°C, rotate for 1.5 hours, and wash with water;

[0023] 2. Secondary degreasing: 230 parts of water, 0.3 parts of penetrant T, 1.5 parts of soda ash, temperature 37-38 ℃, rotation for 2 hours, water control;

[0024] 3. Alkali treatment: 80 parts of water, 2.1 parts of sodium sulfide, 1.5 parts of lime powder, 1 part of liming aid, rotate for 2 hours, then add 2 parts of lime powder, rotate for 0.5 hours, add water to 300 parts, rotate 10 parts at intervals of 50 minutes Minutes, temperature 30°C, total time 15h, remove the lye, wash u...

Embodiment 2

[0031] Embodiment 2: The preparation method of the injectable soft tissue biofilling material of the present invention, its steps are as follows, by weight take pigskin weight as 100 parts, the reaction is carried out in the stainless steel drum:

[0032] 1. Degreasing: Take fresh piglet skin, remove the foreign matter on the skin, peel off the subcutaneous fat, and degrease, 250 parts of water, 2 parts of soda ash, temperature 37-38 °C, rotate 1.5b, wash with water;

[0033] 2. Secondary degreasing: 300 parts of water, 0.5 parts of penetrant T, 2.5 parts of soda ash, temperature 37-38 ℃, rotation for 3 hours, water control;

[0034] 3. Alkali treatment: 150 parts of water, 3.1 parts of sodium sulfide, 4 parts of lime powder, 2 parts of liming aid, rotate for 2 hours, then add 4 parts of lime powder, rotate for 1.5 hours, add water to 270 parts, rotate 10 parts at intervals of 50 minutes minutes, the temperature is 35°C, the total time is 20 hours, the lye is removed, and the ...

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PUM

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Abstract

A process for preparing the biologic filler able to be injected in soft tissue for repairing it or beautifying skin includes such steps as providing the fresh skin of piglet, removing subcutaneous fat, immersing in defatting liquid for defatting, defatting again, alkali treating, removing alkali, cutting for layering, softening by enzyme liquid, cross-linking, water washing, bleaching, cutting to become particles, packing and Co-60 irradiation.

Description

(1) Technical field [0001] The invention relates to the technical field of medical plastic surgery, and relates to an injectable soft tissue biological filling material and a preparation method thereof. (2) Background technology [0002] In the clinical operation of plastic surgery, it is often necessary to fill and repair the congenital hypoplasia or acquired depression deformity of some parts of the soft tissue on the body surface. The filling and repair of filling materials is a necessary means of treatment. An ideal filling material should meet the following requirements: (1) safety, that is, excellent tissue compatibility, no toxicity, inflammation, foreign body reaction, allergy, no antigenicity, no carcinogenicity; ( 2) It has a certain strength, good physical and chemical stability, corrosion resistance, does not produce leached substances of toxic substances, has little absorption, and does not shift; (3) Simple operation, easy shaping, non-magnetic, easy disinfecti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/38
Inventor 曹成波王勇邹玉萍吕荣晖
Owner SHANDONG UNIV
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