Oral loratadine disintegrating tablet and its prepn

A technology of orally disintegrating tablets and loratadine, which is applied in pill delivery, respiratory diseases, drug combination, etc., can solve the problems of high equipment cost, long disintegration time, and short disintegration time, and achieves a simple and convenient preparation method , Guaranteed therapeutic effect and short disintegration time

Inactive Publication Date: 2006-03-01
CHONGQING CONQUER PHARML
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is difficult for the elderly, children and those with dysphagia to swallow ordinary tablets and capsules, especially long-term use will lead to poor compliance of patients, so that the therapeutic effect cannot be guaranteed; and syrups are inconvenient to carry
[0005] Of course, there are also people of insight who have done research on the preparation of orally disintegrating tablets of loratadine: in order to achieve the purpose of short disintegration time, researchers have used f...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1: A loratadine orally disintegrating tablet, which is characterized in that it is composed of 11% loratadine as the main drug, 22% microcrystalline cellulose as filler and 56% mannitol as the disintegrating tablet. The low-substituted hydroxypropyl cellulose 8% as the antidote, the aspartame 2% as the flavoring agent, and the magnesium stearate, polyethylene glycol 6000 and talc as the lubricant accounted for 0.3% of the dry particles. %, 0.5%, 0.2%.

[0037] The specific preparation method is as follows:

[0038] First, the above-mentioned ingredients are pretreated by drying, crushing, sieving, etc.; mixing the pretreated main medicine, filler, flavoring agent and 6% disintegrant low-substituted hydroxypropyl cellulose; Add water to make soft material; use a 24-mesh sieve to granulate; dry the obtained granules at 50°C, when they are nearly dry, sizing, and then continue to dry to meet the requirements; and then in the dried granules, according to the above compo...

Embodiment 2

[0039] Example 2: Loratadine orally disintegrating tablet, wherein the proportion of each component is the same as that of Example 1; the preparation method is directly prepared by powder compression method.

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PUM

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Abstract

The present invention relates to loratadine medicine, and is especially oral loratadine disintegrating tablet for treating allergic diseases and its preparation process. The oral loratadine disintegrating tablet consists of loratadine 11 wt%, micro crystal cellulose 56 wt%, mannitol 22 wt%, low substituted hydroxypropyl cellulose 8 wt%, and aspartame 2 wt%, except lubricant comprising magnesium stearate, polyglycol-6000 and talcum. The preparation process includes the pre-treatment of the components, mixing, pelletizing, drying, further mixing with lubricant, and tabletting. The present invention has short disintegrating time and easy taking.

Description

Technical field [0001] The invention relates to a loratadine medicament, in particular to a loratadine orally disintegrating tablet for treating allergic diseases and a preparation method thereof. Background technique [0002] Loratadine, the chemical name is: 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cycloheptyl[1,2-b]pyridine-11-ene)-1 -Ethyl piperidine carboxylate. It was developed by Schering-Plough of the United States and first went public in 1988. It is now on the market in 89 countries and sold as over-the-counter drugs in 15 countries. In recent years, the sales of loratadine in the international market have grown rapidly, and it has become the world's best-selling antihistamine. [0003] Loratadine is a new oral, potent and long-acting tricyclic antihistamine. Its pharmacological effects include: ①Long-acting, strong and specific competition for peripheral H1 receptors, blocking the effect of histamine; ②Inhibiting the immune release of inflammatory mediators; ③Anti-allergi...

Claims

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Application Information

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IPC IPC(8): A61K31/4545A61K9/20A61P11/02A61P37/08
Inventor 王从芬陈艳秋
Owner CHONGQING CONQUER PHARML
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