Drop pills of oil of zedoary turmeric, and preparation method

A technology of zedoary turmeric oil and medicine, applied in the field of medicine, can solve the problems of low degree of pure naturalness, low degree of naturalness, and low degree of pureness of dropping pill excipients, so as to reduce the irritating smell of medicines, improve the pH of the oral cavity, and achieve the degree of pure naturalness. high effect

Inactive Publication Date: 2006-12-06
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The drop pill preparation has high efficiency and quick effect, and it overcomes some shortcomings and deficiencies of traditional Chinese medicine preparations in the past, but the drop pill preparation faces the following problems: 1. The pure natural degree of drop pill auxiliary materials is not high: at present, most of the drop pill base auxiliary materials are chemical Synthetic products have a low degree of naturalness, and it is very difficult to find new alternative matrix excipients, especially the search for alternative matrix excipients with a high degree of naturalness and the determination of their preparation process, because the common possible replacement of natural matrix excipients is currently The preparation conditions required for the product are very harsh, and the temperature of the excipients and the dripping conditions of the dripping pills are the key factors affecting the preparation of the dripping pills.
If the melting temperature of the excipient is too high, the viscosity will be low and the plasticity will be poor. If the melting temperature of the excipient is too low, although the plasticity is strong, the dropping pills have disadvantages such as easy sticking and deformation. The accessories are very hard work
2. Problems encountered in the export of dripping pills: With the development of the economy, the market is becoming more and more internationalized, and China is also trying to adapt to this trend. Currently, Chinese medicine dripping pills, which are used as health food, have been successfully exported to many countries, but There are also many problems at present, because different countries have different approvals for the excipients selected for the preparation of Chinese medicine dripping pills, especially in Europe with developed industries, which have stricter regulations on food excipients and pharmaceutical excipients, and the drops exported as health food The chemically synthesized auxiliary materials (such as polyethylene glycol) selected for pill preparations are not listed in the food additive catalogs of some countries, which is very unfavorable for Chinese medicine dripping pill preparations to enter the international market, and has become a stumbling block for Chinese medicine to enter the international market. Therefore, looking for One or more new matrix excipients t

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0048] Example 1

[0049] (a) Take 5.8 g of turmeric oil, 19.6 g of xylitol, and 6.7 g of starch for use;

[0050] (b) Take xylitol and starch and mix evenly, add the above-mentioned turmeric oil and mix thoroughly, heat and melt the mixture at 64℃, stir evenly, stirring time is 10-30 minutes, keep warm, drip at 64℃, dropper diameter is 1.2 ~ 2.5 mm, drip into the methyl silicone oil at 0°C to make 1000 drop pills, drain the drop pills and wipe off the coolant to get it.

Example Embodiment

[0051] Example 2

[0052] (a) Take 2.0 g of turmeric oil, 17.8 g of lactitol, and 4.2 g of starch for use;

[0053] (b) Take lactitol and starch and mix evenly, add the above-mentioned turmeric oil and mix thoroughly, heat and melt the mixture at 64℃, stir evenly, stirring time is 10-30 minutes, keep warm, drip at 64℃, dropper diameter is 1.2 ~2.5 mm, drip into methyl silicone oil at 0°C to make 1000 drop pills, drain the drop pills and wipe off the cooling liquid to get it.

Example Embodiment

[0054] Example 3

[0055] (a) Take 4.0 g of turmeric oil, 25.9 g of xylitol, and 7.1 g of gum arabic for use;

[0056] (b) Take xylitol and gum arabic and mix evenly, add the above-mentioned turmeric oil and mix thoroughly, heat and melt the mixture at 64℃, stir evenly, stirring time is 10-30 minutes, keep warm, drip at 64℃, dropper diameter The diameter is 1.2 ~ 2.5 mm, and it is dripped into methyl silicone oil at 0°C to make 1000 drop pills. Drain the drop pills and wipe off the coolant to get it.

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Abstract

A dripping pill of zedoary oil for treating bronchitis features high natural level and safety and low toxic by-effect. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a medicine for treating respiratory diseases and viral pneumonia made from traditional Chinese medicines. Background technique [0002] Curcuma oil is a volatile oil extracted from Zingiberaceae plants, Curcuma curcuma, Curcuma curcuma, and Curcuma curcuma in Guangxi. Its main components are a variety of sesquiterpenoids, including more than 20 components such as curcumol, curcumone, curdione, and B-sitosterol. . Modern studies have proved that zedoary oil has a variety of pharmacological effects and a wide range of clinical applications. There are also reports in the literature that zedoary oil is mixed with an appropriate amount of polyethylene glycol 6000, polyethylene glycol 4000, polyethylene glycol 1500, polyethylene glycol 1000, sodium stearate, glycerin gelatin, poloxamer, stearic acid, mono Stearic acid glyceric acid, insect wax, etc. are made ...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K9/20A61P11/00A61P31/12
Inventor 李永强郑永锋
Owner TIANJIN TASLY PHARMA CO LTD
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