Drop pills of oil of zedoary turmeric, and preparation method

Abstract

A dripping pill of zedoary oil for treating bronchitis features high natural level and safety and low toxic by-effect. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a medicine for treating respiratory diseases and viral pneumonia made from traditional Chinese medicines. Background technique [0002] Curcuma oil is a volatile oil extracted from Zingiberaceae plants, Curcuma curcuma, Curcuma curcuma, and Curcuma curcuma in Guangxi. Its main components are a variety of sesquiterpenoids, including more than 20 components such as curcumol, curcumone, curdione, and B-sitosterol. . Modern studies have proved that zedoary oil has a variety of pharmacological effects and a wide range of clinical applications. There are also reports in the literature that zedoary oil is mixed with an appropriate amount of polyethylene glycol 6000, polyethylene glycol 4000, polyethylene glycol 1500, polyethylene glycol 1000, sodium stearate, glycerin gelatin, poloxamer, stearic acid, mono Stearic acid glyceric acid, insect wax, etc. are made ...

AI Technical Summary

Problems solved by technology

The drop pill preparation has high efficiency and quick effect, and it overcomes some shortcomings and deficiencies of traditional Chinese medicine preparations in the past, but the drop pill preparation faces the following problems: 1. The pure natural degree of drop pill auxiliary materials is not high: at present, most of the drop pill base auxiliary materials are chemical Synthetic products have a low degree of naturalness, and it is very difficult to find new alternative matrix excipients, especially the search for alternative matrix excipients with a high degree of naturalness and the determination of their preparation process, because the common possible replacement of natural matrix excipients is currently The preparation conditions required for the product are very harsh, and the temperature of the excipients and the dripping conditions of the dripping pills are the key factors affecting the preparation of the dripping pills.

If the melting temperature of the excipient is too high, the viscosity will be low and the plasticity will be poor. If the melting temperature of the excipient is too low, although the plasticity is strong, the dropping pills have disadvantages such as easy sticking and deformation. The accessories are very hard work

2. Problems encountered in the export of dripping pills: With the development of the economy, the market is becoming more and more internationalized, and China is also trying to adapt to this trend. Currently, Chinese medicine dripping pills, which are used as health food, have been successfully exported to many countries, but There are also many problems at present, because different countries have different approvals for the excipients selected for the preparation of Chinese medicine dripping pills, especially in Europe with developed industries, which have stricter regulations on food excipients and pharmaceutical excipients, and the drops exported as health food The chemically synthesized auxiliary materials (such as polyethylene glycol) selected for pill preparations are not listed in the food additive catalogs of some countries, which is very unfavorable for Chinese medicine dripping pill preparations to enter the international market, and has become a stumbling block for Chinese medicine to enter the international market. Therefore, looking for One or more new matrix excipients that can be accepted by the international market are particularly important and urgent

3. Disadvantages of mouthfeel and speed of onset of action: Poor taste of traditional Chinese medicine and its preparations is one of its major characteristics. When people take certain medicines, they are far more afraid of the bad taste of the medicine than they are of the disease. What's more, some patients give up the treatment of traditional Chinese medicine because they can't overcome the bad taste or smell of traditional Chinese medicine or its preparations. For example, making the medicine into capsules or sugar-coated tablets can improve the taste and reduce stimulation, but the disintegration speed is prolonged. , which is not conducive to the rapid onset of the drug, and is not suitable for some diseases, especially those that require the rapid onset of the drug

4. Difficult preparation process for industrial production of dripping pills: In the replacement process of dripping pill preparation auxiliary materials, it is very difficult to determine the preparation process for industrial production, such as the melting temperature of matrix auxiliary materials, dripping temperature, auxiliary materials and The ratio of the drug, the ratio of the caliber of the dropper, and the condensing agent are all factors that affect the drop pills. Therefore, it is time-consuming and expensive to replace the matrix and be suitable for industrial production.

[0003] In order to change the situation that the base auxiliary materials of the dropping pills are mainly chemically synthesized auxiliary materials, solve the problem that the base of the dropping pills is currently facing a low degree of naturalness, which is increasingly unable to meet people's requirements for returning to nature, taking pure natural medicines with low toxicity and no side effects It can also solve some problems encountered in the export process of Chinese medicine preparations, especially dripping pill preparations, and enhance the competitiveness of the international market; the present invention has invented a toxic and side effect medicine through a large number of experiments and preparation technology research. Pure Chinese medicine dripping pill preparation with low cost, significant curative effect, moderate price, and suitable for industrialized large-scale production