Enteric-coated capsule of lentinan and preparation method thereof

Abstract

The invention discloses preparing method for mushroom polysaccharide capsule, comprising the following steps: using mushroom as raw material, soaking with water, milling, separating solid and liquid, carrying out ultra filtration, vacuum distilling, thickening, dissolving them with 95% ethanol, separating upper layer, getting precipitate, vacuum distilling to remove water, vacuum drying, extracting particle core, covering particle core with hydroxypropylcellulose, II acrylic resin and III acrylic resin, and getting the product.

Description

technical field [0001] The invention relates to extraction and processing technology of natural products, in particular to lentinan enteric-coated capsules and a preparation method thereof. technical background [0002] Lentinus edodes is a basidiomycete of Pleurotaceae, which contains a variety of medicinal ingredients, especially lentinan, which is mainly mannose, contains a small amount of glucose, trace fucose, galactose, arabinose, etc., and has aspartame in the fetal chain Amino acid, histidine, serine, lysine, glutamic acid and other 18 kinds of amino acids [Wang Suxin, Li Meijun, Pharmacological effects of lentinan, Journal of Dali University, 2002, 1 (4)], lentinan is a A host immune preparation, which has the functions of anti-virus, anti-tumor, regulating immune function and stimulating the formation of estrogen. However, there are problems of extraction and route of administration in existing lentinan oral preparations. If any research proves that lentinan is in...

AI Technical Summary

Problems solved by technology

However, there are problems of extraction and route of administration in existing lentinan oral preparations. If any research proves that lentinan is ineffective through oral administration [Fang Jinian, Wang Shunchun, Research Progress of Lentinan, Chinese Journal of Pharmaceutical Sciences, 1997, 32 (6); 332~333] However, the existing preparations still adopt oral gastric absorption, such as Lentinus polysaccharide tablets produced by Fujian Fuzhou Meifeng Pharmaceutical Factory, and Lentinus polysaccharide tablets produced by Fujian Lijiexun Pharmaceutical Co., Ltd.

In order to avoid the route of administration of lentinan that is ineffective orally, some research institutes and drug manufacturers adopt injection administration, such as the intravenous injection of lentinan produced by Zhuhai Lizhu Pharmaceutical Co., Ltd. in cooperation with the Shanghai Institute of Materia Medica, Chinese Academy of Sciences and Jinling Pharmaceutical Co., Ltd. The company and Fuzhou Meifeng Pharmaceutical Factory also produce lentinan for injection. Since the main indications of lentinan are long-term treatment, injection administration brings a lot of inconvenience to patients and threatens the safety of medication.

[0003] Existing Lentinan is extracted from dried Lentinus edodes, and the drying of fresh Lentinus edodes consumes a lot of energy. Fresh Lentinus edodes has a water content of 90%. If the drying process is too high, the quality of the Lentinus edodes will be damaged, and if the temperature is too low, the quality of the Lentinus edodes will be damaged. Cause mildew, the drying process of shiitake mushroom production mostly adopts the extensive production management of high temperature instead of low, which leads to problems such as poor quality uniformity of lentinan content. Experiments show that: the compound contained in the processing and drying process of traditional Chinese medicine The content changes. Taking raw rehmannia and rehmannia glutinosa as examples, rehmannia glutinosa contains 5 kinds of amino acids, while rehmannia glutinosa contains only trace amounts of water-soluble amino acids [Feng Baolin, "A Preliminary Study on the Processing of Ancient and Modern Traditional Chinese Medicine", first edition, Jinan: Shandong Science and Technology Press , 1984; 168] [Yoshio Kawaguchi, Foreign Medicine. Traditional Chinese Medicine Volume, 1984; (5): 44], the content of catalpol in fresh rehmannia is about twice that of dry rehmannia [Luo Yanyan et al., catalpol in fresh rehmannia and dry rehmannia content, Chinese Journal of Traditional Chinese Medicine, 1994, 29 (1); 38] the reducing sugar of fresh rehmannia glutinosa medicinal material is about one time of rehmannia dry product, and the polysaccharide content of rehmannia dry product is about three times [Sun Xiujie, etc., about the reducing sugar content determination method in rehmannia glutinosa The discussion of Chinese Pharmaceutical Journal, 1989, (1); 39], the mensuration of reducing sugar and polysaccharide of fresh dendrobium and dry dendrobium shows; Chinese Herbal Medicine, 1990, 21 (10); 11] The above-mentioned research results have illustrated that if using lentinan as a medicinal component, fresh mushrooms can be used as a raw material to obtain a higher effective component yield.

[0004] The present invention is to provide an extraction method that can reduce costs and improve the utilization efficiency of medicinal materials, and improve the route of administration to increase the absorption rate of medicinal ingredients. Entering the drug powder through the interface of the capsule, leading to the failure of the effective ingredients and the mechanical movement of the enteric-coated tablet coating during gastric peristalsis, which damages the coating layer. The lentinan preparation and its preparation method for the purpose of improving the curative effect by adopting a multi-layer protection technology scheme