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Bio-activity tricalcium silicate/semi water calcium sulphate composite self-solidification material, preparation and application

A technology of calcium sulfate hemihydrate and tricalcium silicate, applied in the field of medical biological materials, can solve the problems of poor injectability of bone cement paste, no biological activity, inflammatory exudate, etc., and achieve excellent cytocompatibility , excellent biological activity, easy to repeat the effect

Inactive Publication Date: 2007-02-14
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are still some defects in the application of this material, which are mainly reflected in the following aspects: First, although this material has the advantages of fast setting speed and the ability to provide structural support for the defect in a short period of time, the bone cement slurry However, the injectability of the body is poor, and liquid-solid separation may occur during application; secondly, although this material has good biocompatibility and osteoconductivity, it does not have biological activity, and whether this material has induced Osseousness remains controversial; again, clinical studies have shown that this material degrades too quickly in the body to easily lead to a large amount of inflammatory exudate at the repair site, and release a large amount of SO during the degradation process 4 2- There are also metabolic problems

Method used

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  • Bio-activity tricalcium silicate/semi water calcium sulphate composite self-solidification material, preparation and application
  • Bio-activity tricalcium silicate/semi water calcium sulphate composite self-solidification material, preparation and application
  • Bio-activity tricalcium silicate/semi water calcium sulphate composite self-solidification material, preparation and application

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Experimental program
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Effect test

Embodiment 1

[0050] 1) Blending liquid preparation

[0051] Weigh 1.0 g of analytically pure sodium bicarbonate and dissolve it in 99.0 g of deionized water to obtain a 1.0% sodium bicarbonate solution, sterilize, seal it in a sterile bottle, and set aside.

[0052] 2) Preparation of tricalcium silicate / β-calcium sulfate hemihydrate composite bone defect filling material:

[0053] Tricalcium silicate and β-calcium sulfate hemihydrate powder are mixed at a mass ratio of 60:40 (the content of β-calcium sulfate hemihydrate is 40%) to obtain tricalcium silicate / β-calcium sulfate hemihydrate composite powder. The composite powder and the blending liquid are blended for 0.5-1 minute at a liquid-solid mass ratio of 0.8:1 to obtain the tricalcium silicate / β-calcium sulfate hemihydrate composite bone defect filling material. This material is not injectable, the initial setting and final setting time are 9 minutes and 12 minutes respectively; after curing for 28 days, the compressive strength is 37...

Embodiment 2

[0055] 1) Blending liquid preparation

[0056] Weigh 1.0 g of analytically pure gelatin and dissolve it in 99.0 g of deionized water to obtain a 1.0% gelatin solution, sterilize, seal in a sterile bottle, and set aside.

[0057] 2) Preparation of tricalcium silicate / β-calcium sulfate hemihydrate composite self-curing material:

[0058] Tricalcium silicate and β-calcium sulfate hemihydrate are mixed in a mass ratio of 70:30 (the content of β-calcium sulfate hemihydrate is 30%) to obtain tricalcium silicate / β-calcium sulfate hemihydrate composite powder. The composite powder and the blending liquid are blended for 0.5-1 minute according to the liquid-solid mass ratio of 1:1, and the tricalcium silicate / β-calcium sulfate hemihydrate composite self-curing material is obtained. figure 1 For this reason, the XRD pattern of the composite self-curing material after curing for 7 days, L / P=1.0, it can be seen from the figure that the cured material contains calcium sulfate dihydrate a...

Embodiment 3

[0060] 1) Blending liquid preparation

[0061] Prepare 2L of simulated body fluid, place it in a plastic bottle, and store it at 5-10°C.

[0062] 2) Preparation of tricalcium silicate / α-calcium sulfate hemihydrate composite self-curing material:

[0063] Tricalcium silicate and α-calcium sulfate hemihydrate are mixed in a mass ratio of 7:3 (the content of α-calcium sulfate hemihydrate is 30%) to obtain tricalcium silicate / α-calcium sulfate hemihydrate composite powder. The composite powder and the simulated body fluid are mixed for 0.5-1 minute according to the liquid-solid mass ratio of 1:1 to obtain the tricalcium silicate / α-calcium sulfate hemihydrate composite self-curing material. This material has good injectability, the initial setting time and final setting time are 20 minutes and 35 minutes respectively; after curing for 28 days, the compressive strength is 51MPa. The material can be injected and has both mechanical strength and is suitable for oral cavity and minim...

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Abstract

A self-solidifying bioactive composition in the form of paste for repairing bone and tooth is proportionally prepared from the mingling liquid chosen from deionized water, simulative body fluid, inorganic salt solution and gelatin, and the composite powder consisting of tricalcium silicate and semi-hydrated calcium sulfate.

Description

technical field [0001] The invention relates to a bioactive tricalcium silicate / calcium sulfate hemihydrate composite self-curing material, its preparation and application, and relates to a filling and repairing material for human hard tissue defects, that is, as a bioactive material for filling and repairing human bone and tooth defects. , dental and minimally invasive treatments, belonging to the field of medical biomaterials. Background technique [0002] In the restoration of human bone tissue and tooth defects, calcium phosphate bone cement can be used to fill and repair the defect. At present, with the help of minimally invasive treatment, people design the filling material into a paste that can be injected and self-cured in the body for injection treatment, which not only avoids the complicated process of traditional surgery, reduces the pain of patients, but also greatly reduces the Treatment costs. [0003] Since Chow et al. proposed the concept of calcium phospha...

Claims

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Application Information

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IPC IPC(8): A61L27/46
Inventor 常江赵文渊
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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