Calcium sulfate semihydrate group combined self-curing bio-active material, preparation and application thereof

A calcium sulfate hemihydrate, bioactive technology, applied in the field of human hard tissue defect filling repair materials, human bone and tooth defect filling and repairing bioactive materials, can solve the lack of long-term structural support, poor injectability of bone cement paste, Metabolism and other issues, to achieve excellent biological activity and biocompatibility, excellent biological performance, and simple preparation process
CN1923302AInactive Publication Date: 2007-03-07SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
Publication Date
2007-03-07
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a self-solidification biological active material of hemigydrate calcium sulfate base, relative production and application. Wherein, the invention is characterized in that: said material is paste formed by harmony liquid, hemigydrate calcium sulfate / tricalcium silicate composite powder, while their mass ratio is 0.8-1.2:1; said harmony liquid is one of deionized water, analogue humor, inorganic salt solution or inorganic solution; the content of tricalcium silicate in the hemigydrate calcium sulfate / tricalcium silicate composite is 1-50%. The invention can be shaped freely, without cell toxicity, while it can be degraded stepped with adjustable speed, and it can induce the generation of skeleton agustite, with higher activity then calcium sulfate material.
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Description

technical field

[0001] The invention relates to a calcium sulfate hemihydrate-based composite self-curing bioactive material, its preparation and its application. More precisely, the invention relates to a human body hard tissue defect filling and repairing material, that is, as a biological material for filling and repairing human bone and tooth defects. Active materials, uses in orthopedics, dentistry and minimally invasive treatments. It belongs to the field of medical biomaterials. Background technique

[0002] Calcium sulfate cement (Calcium Sulfate Cements, CSCs) has been used as a bone defect filling material for more than 100 years, and its earliest related research can be traced back to 1892 (Henry et al., Clinical Pharmaco-kinetics 1995; 29:36-45). β-calcium sulfate hemihydrate (CaSO 4 1 / 2H 2 O, Calcium Sulfate Hemihydrate, CSH) is calcium sulfate dihydrate (CaSO 4 2H 2 O, Calcium Sulfate Dihydrate, CSD) is a flaky crystal obtained by heating and dehydrating ...

Claims

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