Glycopeptide conjugate microsphere or microcapsule and its preparation process
A technology of conjugates and microspheres, which can be used in the directions of microcapsules, inactive components of polymer compounds, and capsule delivery, etc., can solve the problems of complicated microcapsule steps, and achieve good histocompatibility, degradability, and reaction conditions. mild, active effect
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Embodiment 1
[0046] Dissolve 4 grams of chitosan in 100ml of deionized water (containing 2.8ml of glacial acetic acid), add 100ml of absolute ethanol and 32ml of pyridine after all dissolve, stir until clear, then add 3.6ml of acetic anhydride, and stir at room temperature for 2 hours. The reaction solution was poured into ethanol and filtered with suction to obtain a white precipitate. The crude product was dissolved in water, and the insoluble matter was removed by centrifugation. The filtrate was added with 200ml of absolute ethanol, and the supernatant was discarded after centrifugation. The precipitate was washed with acetone and anhydrous ether in turn, and dried in vacuum at room temperature for 24 hours to obtain a white flocculent solid. The degree of deacetylation of the product measured by acid-base titration was 43%.
[0047] Under Ar protection, prepare 0.1g / 10ml above-mentioned chitosan aqueous solution in 100ml three-neck flask. Weigh 0.6825g of L-leucine-N-carboxylic acid ...
Embodiment 2
[0049] Dissolve 4 grams of chitosan in 100ml of deionized water (containing 2.8ml of glacial acetic acid), add 100ml of absolute ethanol and 32ml of pyridine in turn after all the dissolution, stir until clear, then add 3.6ml of acetic anhydride, and stir at room temperature for 3 hours. The reaction solution was poured into ethanol and filtered with suction to obtain a white precipitate. Dissolve the crude product with an appropriate amount of deionized water, centrifuge to remove insoluble matter, add 200ml of absolute ethanol to the filtrate, discard the supernatant after centrifugation, wash the precipitate with acetone and anhydrous ether in turn, and dry it in vacuum at room temperature for 24 hours to obtain a white flocculent solid. The degree of deacetylation of the product measured by acid-base titration was 43%.
[0050] Under Ar protection, prepare 0.1g / 10ml above-mentioned chitosan aqueous solution in 100ml three-neck flask. Weigh 0.4263g of L-leucine-N-carboxyl...
Embodiment 3
[0052] Dissolve 4 grams of chitosan in 100ml of deionized water (containing 2.8ml of glacial acetic acid). After all of the solution is dissolved, add 100ml of absolute ethanol and 32ml of pyridine in turn, stir until clear, then add 3.4ml of acetic anhydride, and stir at room temperature for 4 hours. The reaction solution was poured into ethanol and filtered with suction to obtain a white precipitate. Dissolve the crude product with an appropriate amount of deionized water, centrifuge to remove insoluble matter, add 200ml of absolute ethanol to the filtrate, discard the supernatant after centrifugation, wash the precipitate with acetone and anhydrous ether in turn, and dry it in vacuum at room temperature for 24 hours to obtain a white flocculent solid. The degree of deacetylation of the product measured by acid-base titration was 50%.
[0053] Under Ar protection, prepare 0.1g / 10ml above-mentioned chitosan aqueous solution in 100ml three-neck flask. Weigh 1.3382g N ε -Ben...
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