Inhibitors of the ICE/ced-3 family of cysteine proteases

a protease and inhibitor technology, applied in the direction of depsipeptides, peptide/protein ingredients, chemical treatment enzyme inactivation, etc., can solve the problems of poor stability and rapid metabolism, poor pharmacologic properties, poor cell penetration, etc., to improve cell penetration, improve absorption and metabolic stability, and improve the effect of properties
US20050065093A1Inactive Publication Date: 2005-03-24IDUN PHARMA INC
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
IDUN PHARMA INC
Publication Date
2005-03-24
Estimated Expiration
Not applicable · inactive patent

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Abstract

This invention is directed to novel oxamyl dipeptide ICE / ced-3 family inhibitor compounds having the following structure: wherein A, B, R, R1, R1′ p and q are as defined herein. The invention is also directed to pharmaceutical compositions containing one or more of these compounds, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.
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Description

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to novel classes of compounds which are inhibitors of interleukin-1β converting enzyme and related proteases (“ICE / ced-3 family of cysteine proteases”), as well as pharmaceutical compositions comprising these compounds and to methods of using such pharmaceutical compositions. 2. Description of the Related Art Interleukin 1 (“IL-1”) is a major pro-inflammatory and immunoregulatory protein that stimulates fibroblast differentiation and proliferation, the production of prostaglandins, collagenase and phospholipase by synovial cells and chondrocytes, basophil and eosinophil degranulation and neutrophil activation. Oppenheim, J. H. et al., Immunology Today 7:45-56 (1986). As such, it is involved in the pathogenesis of chronic and acute inflammatory and autoimmune diseases. IL-1 is predominantly produced by peripheral blood monocytes as part of the inflammatory response. Mosely, B. S. et al., Proc. Nat...

Claims

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