Engineered particles and methods of use

a technology of microstructures and particles, applied in the direction of aerosol delivery, spray delivery, antinoxious agents, etc., can solve the problems of increasing the flowability of the resulting powder, lowering the shear force, etc., to improve the flowability and dispersibility, improve the delivery of agents, and reduce the attractive force
US20050074498A1Inactive Publication Date: 2005-04-07NOVARTIS FARMA
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
NOVARTIS FARMA
Publication Date
2005-04-07
Estimated Expiration
Not applicable · inactive patent

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Abstract

Engineered particles are provided may be used for the delivery of a bioactive agent to the respiratory tract of a patient. The particles may be used in the form of dry powders or in the form of stabilized dispersions comprising a nonaqueous continuous phase. In particularly preferred embodiments the particles may be used in conjunction with an inhalation device such as a dry powder inhaler, metered dose inhaler or a nebulizer.
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Description

FIELD OF THE INVENTION The present invention relates to formulations and methods for the production of perforated microstructures which comprise an active agent. In particularly preferred embodiments, the active agent will comprise a bioactive agent. The perforated microstructures will preferably be used in conjunction with inhalation devices such as a metered dose inhaler, dry powder inhaler or nebulizer for both topical and systemic delivery via pulmonary or nasal routes. BACKGROUND OF THE INVENTION Targeted drug delivery means are particularly desirable where toxicity or bioavailability of the pharmaceutical compound is an issue. Specific drug delivery methods and compositions that effectively deposit the compound at the site of action potentially serve to minimize toxic side effects, lower dosing requirements and decrease therapeutic costs. In this regard, the development of such systems for pulmonary drug delivery has long been a goal of the pharmaceutical industry. The thre...

Claims

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