Novel phosphorus-containing prodrugs

a phosphorus-containing, prodrug technology, applied in the field of new phosphorus-containing prodrugs, can solve the problems of poor oral bioavailability, poor cell penetration and limited tissue distribution, poor drug effect, etc., to reduce the production of enzymes, reduce the activity of phosphorylating enzymes, and improve the effect of drug
US20070249564A1Inactive Publication Date: 2007-10-25METABASIS THERAPEUTICS INC
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
METABASIS THERAPEUTICS INC
Publication Date
2007-10-25
Estimated Expiration
Not applicable · inactive patent

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Abstract

Novel cyclic phosphoramidate prodrugs of drugs of formula I their use in delivery of drugs to the liver, their use in enhancing oral bioavailability, and their method of preparation are described.
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Description

RELATED APPLICATION

[0001] This application is a continuation-in-part of Provisional Application Ser. No. 60 / 153,127, filed Sep. 8, 1999, and Provisional Application Ser. No. 60 / 123,013, filed Mar. 5, 1999, and they are incorporated by reference in their entirety.FIELD OF THE INVENTION

[0002] The present invention is directed towards novel prodrugs that generate phosph(on)ate compounds which are biologically active or are further phosphorylated to produce biologically active compounds, to their preparation, to their synthetic intermediates, and to their uses. More specifically, the invention relates to the area of substituted cyclic 1,3-propanyl esters wherein the cyclic moiety contains at least one amino attached to the phosphorus. BACKGROUND OF THE INVENTION

[0003] The following description of the background of the invention is provided to aid in understanding the invention, but is not admitted to be, or to describe, prior art to the invention. All cited publications are incorpora...

Claims

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