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Sustained release of nutrients in vivo

a technology of glycemic response and nutrients, applied in the field of sustained release of nutrients in vivo, can solve problems such as difficulty in task, and achieve the effect of improving athletic performance, enhancing glycemic response, and prolonging glycemic respons

Inactive Publication Date: 2012-01-19
NEW WORLD PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0008]The inventors have discovered compositions for in vivo administration, which surprisingly provide an elevated and prolonged glycemic response compared to conventional food products, such as GATORADE®. The present invention is based upon the premise that athletic performance can be improved by providing controlled release of nutritional supplements (such as carbohydrates and electrolytes).
[0009]The present invention relates to a composition comprising nutritional supplements (such as carbohydrates, amino acids, vitamins, and / or electrolytes), which when administered to a human provides a sustained release of the nutritional supplements over an extended period of time. Preferably, the nutritional supplements may be delivered in a sustained and extended manner for peak athletic performance and recovery. For instance, the composition may release the nutritional supplements so that absorption and oxidation rates of exogenous carbohydrates are increased during exercise. According to one embodiment, the composition releases nutritional supplements such that saturation of the SGLT1 and GLUT-5 transporters with exogenous carbohydrates is maintained during exercise.

Problems solved by technology

However, this is a difficult task, especially for athletes in training who need a sustained supply of carbohydrates and other nutrients without the drawback of an intake of large amounts or smaller amounts but at more regular intervals, of food in order to meet the dietary requirements necessary to maintain enhanced performance.

Method used

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  • Sustained release of nutrients in vivo
  • Sustained release of nutrients in vivo
  • Sustained release of nutrients in vivo

Examples

Experimental program
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Effect test

example 1

Delayed-Release Carbohydrate Formulations for Athletic Performance Enhancement

[0181]The goal of the Example is to develop a nutrition fluid that delivers carbohydrates and other nutrients to an athlete in a manner that promotes peak athletic performance. The proposed approach is to engineer controlled release of digestible carbohydrates from aqueous dispersion of suitable micro or nanospheres. Important digestible carbohydrates include: the monosaccharides—glucose, fructose and galactose; the dissacharides—sucrose, maltose and lactose; and the polysaccharide, starch. Starch is broken down in to dextrins by salivary amylase (in the mouth) and pancreatic amylase (in the small intestine). Dextrin is acted upon by the brush border enzymes in the small intestine, which also convert the double sugars into simple sugars. The monosaccharides are finally transported across the intestinal epithelium into the bloodstream. The proposed research seeks controlled release of digestible carbohydrat...

example 2

[0236]Further to the various aspects of the invention detailed above, a basic understanding of the relative importance of carbohydrates (CHOs) as energy sources is useful in the design of the delivery systems of the invention. Food formulations that can improve endurance capacity and exercise performance of athletes have been the focus of several studies in sports and exercise sciences.i Athletes require a continuous supply of fuel during exercise to avoid fatigue. Proteins, fats and carbohydrates have all been considered as important components of an athlete's diet,ii,iii but the current emphasis on carbohydrate-rich diet for athletes has its basis in studies conducted about 90 years ago. These early studies suggested a relationship between blood glucose concentration and fatigue. Levine et al., in 1924, found that a carbohydrate-rich diet for participants of a 25-mile marathon race, resulted in improved running performance (measured as the time to complete the race) and prevented ...

example 2.1

[0280]Hydroxypropyl cellulose (HPC-SL, 4 g) was dissolved in 50 g of distilled water in a 250-mL Erlenmyer flask, at room temperature, using a magnetic stirrer. To the HPC solution in the Erlenmyer flask, an aqueous solution of soy lecithin was added, and the mixture was stirred for 5 min until a homogenous pale yellow solution was obtained. To this solution, an aqueous solution of TSTMP was added in three aliquots, with stirring for 2 min between each addition. The cloudiness of the formulation increased after the addition of TSTMP, indicating particle formation. Finally, an aqueous solution of sodium hydroxide was added, and the dispersion was stirred for 5 min. The pH of this dispersion was measured using a pH meter and was about 11.6. The resulting formulation was heated for 2 h on a water bath maintained at 50° C. using a hot plate (Corning Instruments PC 620D) and stirred at 300 rpm using a magnetic stirrer. A solid precipitate formed during the reaction. The Erlenmyer flask w...

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Abstract

Nutritional compositions delivered in vivo in a time controlled manner sustainable over long periods of time, provide enhancing athletic performance, increased hand / eye coordination and concentration on the task at hand.

Description

INCORPORATION BY REFERENCE[0001]This application claims priority to International Application No. PCT / US2008 / 087104, filed Dec. 17, 2008 and to U.S. Application Serial No. 12 / 337,022, filed Dec. 17, 2008, both of which claim the benefit of priority of U.S. provisional patent application Ser. No. 61 / 014,251 filed Dec. 17, 2007.[0002]The foregoing applications, and all documents cited therein or during their prosecution (“appln cited documents”) and all documents cited or referenced in the appln cited documents, and all documents cited or referenced herein (“herein cited documents”), and all documents cited or referenced in herein cited documents, together with any manufacturer's instructions, descriptions, product specifications, and product sheets for any products mentioned herein or in any document incorporated by reference herein, are hereby incorporated herein by reference, and may be employed in the practice of the invention.FIELD OF THE INVENTION[0003]The invention relates to c...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K9/14A61K31/7016A61K31/715A61P3/02A61K31/716A61K31/718A61K9/50A61K31/70A61K31/7004A23L29/262A23L33/00A23L33/15
CPCA23G4/06A23L1/293A23L1/0545A23L1/09A23L1/302A23L1/304A23L1/3051A23L1/3082A23L1/3084A23L2/52A23V2002/00A23L1/052A23L1/0029A23L1/296A23V2200/33A23V2250/51086A23V2250/51A23V2250/5026A23V2250/606A23V2250/608A23V2250/616A23V2250/612A23V2250/5114A23V2250/06A23V2250/50A23P10/30A23L29/206A23L29/272A23L29/30A23L33/30A23L33/40A23L33/16A23L33/175A23L33/24A23L33/25A23L33/125A23L5/00A23L33/15A23L33/26A23P10/25A61P3/02A61P3/08A61P5/50A23L33/10
Inventor SEXTON, FREDERICK A.KRISHNAN, SITARAMANVENDRA, VENKAT KALYAN
Owner NEW WORLD PHARMA
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