Circulating tumor cell capture on a microfluidic chip incorporating both affinity and size

a microfluidic chip and tumor cell technology, applied in the field of medical diagnostics and microfluidics, can solve the problems of many cancers going undetected and damaging healthy tissue, and achieve the effects of high hydrophilicity, minimal damage, and maximum flexibility/solubility and activity
US20140154703A1Inactive Publication Date: 2014-06-05GPB SCI
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
GPB SCI
Publication Date
2014-06-05
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention encompasses methods and devices for diagnosing, theranosing, or prognosing a condition in a patient by enriching a sample in rare cells or other particles. The devices can be a microfluidic device comprising an array of obstacles and one or more binding moieties. The devices and methods can allow for enrichment of cells based on size and affinity, recovery of cells or other particles in locations on the microfluidic device, release of cells or other particles from the microfluidic device, flow of sample through the microfluidic device, and retention of rare cells or other particles from a sample obtained from a patient having a condition.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application claims the benefit of U.S. Provisional Application No. 61 / 430,897, filed Jan. 7, 2011, U.S. Provisional Application No. 61 / 430,891, filed Jan. 7, 2011, U.S. Provisional Application No. 61 / 430,930, filed Jan. 7, 2011, and U.S. Provisional Application No. 61 / 430,509, filed Jan. 6, 2011, which are hereby incorporated by reference.TECHNICAL FIELD

[0002] The invention relates to the fields of medical diagnostics and microfluidics.BACKGROUND

[0003] Cancer is a disease marked by the uncontrolled proliferation of abnormal cells. In normal tissue, cells divide and organize within the tissue in response to signals from surrounding cells. Cancer cells do not respond in the same way to these signals, causing them to proliferate and, in many organs, form a tumor. As the growth of a tumor continues, genetic alterations can accumulate, manifesting as a more aggressive growth phenotype of the cancer cells. If left untreated, metastasis, the ...

Claims

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