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Antimicrobial nonwoven fabric

a non-woven fabric and antimicrobial technology, applied in the field of antimicrobial non-woven fabrics, can solve the problems of major world-wide public health problems, undesired use of high levels of antimicrobial agents, and undesired use of high levels of certain types of antimicrobial agents

Inactive Publication Date: 2014-10-16
AR METALLIZING NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention is related to a filter material that can be used in high-quality air environments such as hospitals and public spaces. The filter material has been metallised to provide antibacterial properties, which can help reduce the microbial load and impact air quality in standalone ventilation circuits. The material can be used alone or in combination with other materials for a variety of products with diverse properties such as apparel, home furnishings, health care, engineering, industrial, and consumer goods. The invention also includes the use of the materials described herein for the control or restriction of antimicrobial growth. Overall, this invention provides a way to enhance the quality of air in various environments and provide better protection against bacteria and other microbes.

Problems solved by technology

Unfortunately, however, the required high levels of antimicrobial agents employed are undesired in many cases.
For instance, the use of high levels of certain types of antimicrobial agents may be undesired due to an increased likelihood of contacting sensitive areas, such as wounds.
This resistance spread is exacerbated by the low number of antibiotics in the development pipeline which could result in a major world-wide public health problem.
However, the use and application of silver salts, or colloidal silver particles usually requires the use of complex application technologies, e.g. sonochemical application or impregnation with dispersions, which—if applicable at all due to the sensitivity of in particular non-woven materials to water or solvents—requires handling of solvents and their removal, as well as drying of the obtained products.
This renders the application process complex and cumbersome.
Furthermore, the silver particles will be distributed over the whole material and not available at the contact area with moisture, such as in skin contact.
Therefore, in order to be effective, such materials require a relatively high silver loading, which makes a widespread use prohibitively difficult.
Yet further, due to the complexity and nature of this process, it is difficult to control the amount of silver deposited on the fibre and furthermore, the amount of silver deposited is limited by the surface area of the fibre.
Other attempts have been made to apply silver salts on the surfaces of fabrics and yarns with little success in terms of controlled release of the silver ions to the wound, while maintaining adequate absorption capabilities.
Thus, a topical treatment with metal-based antimicrobial agents has not been successfully developed and applied to a substrate having the combination of characteristics described herein, as desired for an effective wound care device.
Likewise, hospitals, and generally facilities sensitive to microbiological pathogens have been increasingly facing issues with microbiological contamination of the air, spread through building air handling systems, specifically in Heating Ventilating and Air Conditioning (HVAC) systems.
The microbiological contamination cause odour in their mildest form, but generally may cause much graver issues.
The microbial contamination frequently found includes fungi such as Aspergillus spp., Fusarium spp., Penicillium chrysogenum and / or Candida albicans, but also Legionella, a pathogenic Gram negative bacterium, including species that cause legionellosis or “Legionnaires' disease”, most notably, Legionella pneumophila, has caused many issues with infections transmitted through HVAC systems.
However, films obtained by sputtering methods have generally polycrystalline structures with columnar grains, thereby reducing the available surface area of the metal atoms.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

Antimicrobial Activity

[0080]Non-woven materials were vacuum metallised with various Ag—Cu—Al alloys, and the obtained materials subjected to anti-bacterial tests according to ISO 20743:2007(Textiles—Determination of antibacterial activity of antibacterial finished products). This test is used to quantitatively measure the antimicrobial activity of antibacterial finished textile products including nonwovens.

[0081]Strains tested were: Staphylococcus aureus ATCC 6538 and Klebsiella pneumoniae ATCC 4352.

[0082]Method and principle of the test: Treated samples and control samples are cut in pieces of 3.8 cm diameter. The inoculation is achieved by transfer of bacteria from an agar plate onto samples: Each sample (as well as each control) is placed on the agar surface of an agar plate that has been previously inoculated (by first flooding the agar surface with 1 ml of a bacterial suspension adjusted to a concentration of 1×106 to 3×106 CFU / ml and then sucking up as much of the excess liqui...

example 2

[0102]Example 1 was repeated with a different non-woven tissue substrate.

TABLE 2Sample identificationIdentificationnumberDescription of the samples**Comparative 1Non-woven tissue without vacuum metal layerSample 1Non-woven tissue with vacuum metal layer ofAl / Cu 85 / 15 alloySample 2Non-woven tissue with vacuum metal layer ofCu / Ag 70 / 30 alloyComparative 2Non-woven tissue without vacuum metal layerSample 3Non-woven tissue with vacuum metal layer Al / Cu85 / 15 alloySample 4Non-woven tissue with vacuum metal layer ofCu / Ag 70 / 30 alloyEMPA Cotton 100%Internal Control sample, Untreated**This control was added in order to check the growth and the behaviour of the bacterial strain**The metal layer thickness was 150 nm in all examples; ratio of metals in the alloy are given as wt / wt

TABLE 3Control of the growth value obtained on the internal controlsample and on the untreated samples with Methicillin ResistantStaphylococcus aureus—MRSA; Contact time: 18 hours, Inoculumconcentration: 1.68 106 CFU / ml...

example 3

Results Obtained with Klebsiella pneumoniae

[0104]Examples 1 and 2 were repeated with Klebsiella pneumoniae, see Tables 6 and 7.

TABLE 6Control of the growth value obtained on the internal control sampleand on the untreated samples with Klebsiella pneumoniae - Contact time:18 hours, Inoculum concentration: 2.7 × 106 CFU / mlNumber of viable cellsNumber of viable cellsat Contact time = 0*at Contact time = 18 h*Sample IDTrialCFULog CFUCFULog CFUInternal13.4 × 1044.532.4 × 1088.38Control25.0 × 1054.702.0 × 1088.30EMPA33.2 × 1054.511.9 × 1088.27Cotton 100%Average4.6 ± 0.1 8.3 ± 0.06(log)Growth3.7Value FComparative11.3 × 1055.112.2 × 1088.34Sample 127.6 × 1044.882.0 × 1088.3035.8 × 1044.762.0 × 1088.30Average4.9 ± 0.188.3 ± 0.02(log)F3.4Comparative16.2 × 1045.115.2 × 1077.72Sample 221.3 × 1054.881.5 × 1088.1735.0 × 1044.761.3 × 1088.13Average4.9 ± 0.21  8 ± 0.25(log)F3.1*Colonies expressed per sample;**The growth value was equal or above 1 for all controls

TABLE 7Count of Klebsiella pneumoni...

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Abstract

The present invention relates to woven or nonwoven fabric material having antimicrobial activity, and to its uses ranging from wound dressing, facial masks, surgical drapes and surgical clothing, to filter materials and similar applications where the antimicrobial effects are employed, as well as to a process for the preparation of the woven or nonwoven fabric material.

Description

[0001]The present invention relates to a nonwoven fabric which possesses antimicrobial properties and is useful in applications where the growth of microorganisms should be inhibited, such as surgical drapes, medical devices and clothing, filters for air handling and specific antimicrobial packaging materials.BACKGROUND OF THE INVENTION[0002]In recent years, the increased occurrence of hospital-acquired infections has had serious implications for both patients and healthcare workers. Hospital-acquired infections typically originate in a hospital or long-term care setting. Consequently, hospitals and other healthcare facilities extensively use materials impregnated or otherwise foreseen with antimicrobial agents for a variety of topical applications, such as wound dressings and drapes, and / or sterile drapes and articles that need to be discarded after a short usage due to infection risks.[0003]Surgical drapes are presently made from nonwoven fabrics, and are typically used during sur...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): D06M11/83D06M23/16D06B1/04D06M16/00
CPCD06M11/83D06M16/00D06M23/16D06B1/04C23C14/20D06M10/04D06M10/06Y10T442/608Y10T442/3398Y10T442/3065Y10T442/657A41D13/1192A41D13/1209A41D31/305
Inventor VAN EMMERICK, PAULROPERTO, MAURAGIELEN, PAULA
Owner AR METALLIZING NV
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