63 results about "Proteolipids" patented technology

The invention provides compositions and methods for detection of interaction of molecules.

The present invention generally related to a nanofabricated membrane including polymerized proteoliposomes. The nanofabricated membrane is a bio-nano fused selective membrane using protein-incorporated uv-crosslinkable liposomes with a chemical reactive biocompatible interstitial matrix. In the present invention, internally UV-crosslinked protein-incorporated proteolipsomes are used because the proteoliposomes made by natural lipids have a short life time and a weak resistance to the circumstantial stresses such as a high and low temperature, pressure, ionic strength etc. Furthermore, the proteo-vesicles made by amphiphilic block copolymers provide less consistency in accomplishing proper functionality batch to batch because of the inevitable polydiversity of the polymer.

Methods of preparing a proteoliposome comprise the step of contacting a liposome with an effective portion of RalBP1 to create a proteoliposome. RalBP1 is effective for the protection and treatment of mammals and the environment against the accumulation of toxic compounds, and prevents accumulation of one or more toxic compounds, reduces the concentration of toxic compounds, and protects against further contamination with one or more toxic compounds. In addition, RalBP1 is effective for the protection and treatment of mammals against the effects of ionizing radiation.

The present invention proposes formative agent of protein complex, in which a polyphenol is useful component, and the agent is useful as gene complex, cell adhesion inhibitor or immune tolerogen. The polyphenol of forming the agent is selected from catechin group consisting of epigallocatechin-gallate, tannic acids, or proanto-dianisidine, a protein of the protein complex is selected from proteins consisting of animal proteins composed of polypeptide chain of peptide-combined amino acids, vegetative proteins, nucleus proteins, glycogen proteins, lipo-proteins and metal proteins, the gene complex comprises by compositing genes by polyphenol catechins in order to introduce genes to cells of animals or human bodies, a cell composed of the cell adhesion inhibitor is selected from cells consisting of an animal cell including a stem cell, skin cell, mucosa cell, hepatocyte, islet cell, neural cell, cartilage cell, endothelial cell, epidermal cell, osteocyte or muscle cell isolated from human or animal organism, or sperm, ovum or fertilized egg of domestic animals or fishes and a tissue or an organ for transplantation of the immune tolerogen is selected from the tissue or the organ consisting of skin, blood vessel, cornea, kidney, heart, liver, umbilical cord, bowels, nerve, lung, placenta or pancreas.

The invention discloses a lipid-protein edible double-layer active membrane and a preparation method thereof. The preparation method comprises the following steps: respectively dissolving an alcohol-soluble protein and a water-soluble protein in an acetic acid-water solution, and adding a hydrophobic active substance into the alcohol-soluble protein and / or adding a hydrophilic active substance into the water-soluble protein to respectively obtain an alcohol-soluble protein solution and a water-soluble protein solution; uniformly mixing the alcohol-soluble protein solution with the water-soluble protein solution, and adding a plasticizer; and mixing the film forming solution with solid lipid, heating to a temperature being equal to or higher than the melting point of the lipid, carrying outhigh-speed shearing homogenization to form an emulsion, and casting to form the membrane. The preparation method is simple and convenient, and the protein-lipid double-layer active membrane can be prepared through one-time tape casting, so the drying time can be shortened, and the production efficiency can be improved. The active membrane has a good one-way water blocking effect and good mechanical properties, and the release rate of an active matter can be regulated by regulating the ratio of the alcohol-soluble protein to the water-soluble protein and the mass percentage of the lipid.

The present invention is a hair treatment agent comprising at least one surfactant and at least one proteolipid of the formula R′—X—R″, wherein R′ is a straight-chain or branched, saturated or unsaturated hydrocarbon radical having 11 to 24 carbon atoms; R″ is a protein, a peptide, or a protein hydrolyzate; X is —C(O)O—, —N+(RIII2)RIV—, or —N(RIII)RIV—; RIII is —(CH2)x—CH3— with x=0-22; and RIV is —CH2—CH(OH)—CH2— or —(CH2)x— with x=0-22; with the proviso that R″ consists of keratin or a keratin hydrolyzate when X is —C(O)O—. The agents of the present invention improve many properties of hair such as giving enhanced shine and impregnation of hair.

The present invention belongs to the technical field of nutritious foods, and especially relates to a rectal cancer nutritious food and a preparation method thereof. The rectal cancer nutritious foodcontains nutrient elements including proteins, fat, carbohydrate, vitamins, minerals, ginkgo flavonoids and phytosterol. The nutritious food provided by the invention can provide sufficient and comprehensive nutrients for the organism, more importantly, the food enhances the barrier function of intestinal mucosa, better accords with the metabolic physiological state, facilitates the protein synthesis and metabolism regulation of the organism, promotes the recovery of intestinal function and form, prevents bacteria and toxin translocation, obviously reduces the occurrence of intestinal source infection, and is an effective way to improve the nutritional status of chemotherapy patients. The food has a certain improvement effect on the nutritional status of chemotherapy patients with middle or advanced rectal cancer, can reduce adverse reaction of patients, and can effectively improve the immunity of patients.

The invention describes materials useful for calibrating methods, and standards, calibration verification, linearity, and quality control materials for any method used to detect lipids and / or lipoproteins. This invention describes methods for producing, and compositions produced thereby, stable lipid controls, standards, and reagents including a stabilizing amount of TDPA, and further including a known amount of a substantially pure constituent of interest, including total cholesterol (CHOL), triglycerides (TRIG), high density lipoprotein (HDL), APO lipoprotein A (APO-A), APO Lipoprotein B (APO-B), low density lipoprotein (LDL), apolipoprotein a Lp(a) and other lipoprotein moieties useful for calibrating, standardizing, verifying, quality control, and the like, relating to use of an instrument for assessing the level of such constituents in a sample.

Methods of detecting ZNT8 antibodies in serum are described. The methods include proteoliposomes comprising a transmembrane domain (TMD) and a cytosolic domain (CTD) of ZnT8 proteins exposed on the exterior of the proteoliposome; serum comprising antibodies targeting the ZnT8 proteins; and labelled captured autoantibodies that bind to ZnT8 antibodies.

The invention relates to a process for preparing saposin lipoprotein particles, comprising a saposin-like protein, lipids and optionally a hydrophobic agent wherein the saposin-like protein or the hydrophobic agent is selectively bound to a support to allow the self-assembly of the saposin lipoprotein particles. The process of the invention comprises the step of a.) providing the hydrophobic agent and lipids, b. 1) / b.2) contacting the hydrophobic agent or the saposin-like protein with a support that is capable of selectively binding either of the two molecules to the support, c.1) / c.2) contacting the support-bound particle components with the remaining particle components, either the saposin-like protein or the hydrophobic agent, to allow fpr the self-assembly of the saposin lipoprotein particle on the support and d.) optionally eluting the support-bound saposin lipoprotein particles.

The present invention belongs to the technical field of nutritious foods, and especially relates to a colon cancer nutritious food and a preparation method thereof. The colon cancer nutritious food contains nutrient elements including proteins, fat, carbohydrate, vitamins, minerals, amino acidss, ginkgo flavonoids and phytosterol. The nutritious food provided by the invention can provide sufficient and comprehensive nutrients for the organism, more importantly, the food enhances the barrier function of intestinal mucosa, better accords with the metabolic physiological state, facilitates the protein synthesis and metabolism regulation of the organism, promotes the recovery of intestinal function and form, prevents bacteria and toxin translocation, obviously reduces the occurrence of intestinal source infection, and is an effective way to improve the nutritional status of chemotherapy patients. The food has a certain improvement effect on the nutritional status of chemotherapy patients with middle or advanced colon cancer, can reduce adverse reaction of patients, and can effectively improve the immunity of patients.

This invention relates to the design and construction of a gene encoding an encephalogenic epitope of proteolipid protein (PLP), design and construction of a gene encoding an encephalogenic epitope of myelin based protein (MBP), to methods of expression of a PLP epitope, to methods of expression of a MBP epitope, to methods of in vivo secretion of a PLP epitope, and to methods of transferring the partial PLP gene to a host to ameliorate the progression of an immune response to self antigens derived from myelin proteins, to methods of in vivo secretion of a MBP epitope, and to methods of transferring the partial MBP gene to a host to ameliorate the progression of an immune response to self antigens derived from myelin proteins.