The invention discloses an automatic glass panel machining device. The automatic glass panel machining device comprises a machining machine tool, an automatic feeding device, a conveying combined device and a disc collecting device. The machining machine tool comprises a workbench, a tool beam, a tool and a clamping device. The automatic feeding device is arranged at one end of the machining machine tool and used for containing and conveying to-be-machined material frames. The conveying combined device comprises a conveying frame, transmission assemblies and jacking devices, the automatic feeding device can convey the material frames to the conveying frame, the transmission assemblies drive the material frames to move along the conveying frame, the material frames pass through the jackingdevices, and the jacking devices can jack the material frames. The disc collecting device is arranged at the end, away from the automatic feeding device, of the machining machine tool, and the disc collecting device is used for collecting the empty material frames conveyed through the conveying combined device. Accordingly, according to the machining device of the structure, feeding and discharging are automatically achieved in a whole machining production line, the labor force is saved, meanwhile, the machining precision is guaranteed, generation of defective products is reduced, and efficiency is improved.