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Process for preparing biologically degradable reverse temperature sensitive material

A sensitive material and biological technology, which can be used in medical preparations containing active ingredients, drug delivery, pharmaceutical formulations, etc., can solve the problems of high injection temperature, high polymer concentration, affecting clinical application prospects, etc., and achieves a simple preparation process. , the effect of increasing hydrophobic interaction, good clinical application potential

Inactive Publication Date: 2007-11-07
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this type of material may affect its clinical application prospects due to its high injection temperature and high polymer concentration.
At present, some temperature-sensitive materials that are liquid at room temperature and solid at body temperature have some problems in terms of stability, gel strength, biocompatibility or biodegradability. For example, the literature "Yong Qiu, KinamPark, Environment-sensitive hydrogels for drug delivery, Advanced Drug Delivery Reviews 53(2001) 321-339”

Method used

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  • Process for preparing biologically degradable reverse temperature sensitive material
  • Process for preparing biologically degradable reverse temperature sensitive material
  • Process for preparing biologically degradable reverse temperature sensitive material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Dissolve the gelatin powder obtained by removing impurities in water to make a solution with a mass / volume concentration of 4%, filter and remove impurities for later use; add network penetration assistant polypropylene alcohol to the solution, and the mass ratio of gelatin to polypropylene alcohol is 1: 1. Heat at 70-80°C until completely dissolved, control the final mass / volume concentration of the system to 8.0%, cool to room temperature, and defoam; add epichlorohydrin dropwise while stirring until the final concentration is 100 μM; the cross-linking reaction is completed Finally, transfer to an ice-water bath, add a saturated aqueous solution containing sodium glucose phosphate, so that the final mass / volume concentration of sodium glucose phosphate is 10%, and take 30 to 60 minutes; slowly add a saturated aqueous solution of disodium hydrogen phosphate, adjust the pH to 7.4, and divide Assemble, do 3 groups of parallel experiments.

Embodiment 2

[0020] Dissolve the chitosan powder obtained from impurity removal in acetic acid solution to make a solution with a mass / volume concentration of 0.9%, filter to remove impurities for later use; add network penetration additive polyvinyl alcohol, chitosan and polyvinyl alcohol to the solution The mass ratio is 10:1, heated at 70-80°C until completely dissolved, the final mass / volume concentration of the control system is 1.0%, cooled to room temperature, defoaming; while stirring, add glutaraldehyde concentration dropwise to a final concentration of 0.1μM; After the cross-linking reaction is over, transfer to an ice-water bath, add a saturated aqueous solution containing sodium glycerophosphate until the final mass / volume concentration of sodium glycerophosphate is 15%, 30-60 minutes; slowly add saturated disodium hydrogen phosphate dropwise Aqueous solution, adjust the pH to 7.2, subpackage, and do 3 groups of parallel experiments.

Embodiment 3

[0022] Dissolve the xanthan gum powder obtained by removing impurities in water to make a solution with a mass / volume concentration of 0.2%, filter and remove impurities for later use; add network penetration additive polypropylene alcohol to the solution, the quality of xanthan gum and polypropylene alcohol The ratio is 1:10, heated at 70-80°C until it is completely dissolved, the final mass / volume concentration of the control system is 2.0%, cooled to room temperature, and defoamed; while stirring, add sodium polyphosphate dropwise to a final concentration of 1000 μM; After the cross-linking reaction is over, turn to an ice-water bath, add a saturated aqueous solution containing potassium fructose phosphate until the mass / volume concentration of potassium fructose phosphate is 0.5%, and take 30 to 60 minutes; slowly add a saturated aqueous solution of disodium hydrogen phosphate dropwise to adjust the pH to 7.4, subpackage, do 3 groups of parallel experiments.

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PUM

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Abstract

The present invention relates to preparation process of biodegradable reverse temperature sensitive material used for medicine conveying system, cell embedment, biological tissue engineering and medical equipment. The present invention adopts biodegradable polysaccharide material, such as gelatin, xanthan gum, chitosan and xylan as main skeleton material, and introduces interpenetrating network assistant polyenol to form double crosslinked or hybridized gel network structure. The preparation process includes crosslinking polysaccharide and polyenol in water solution with crosslinking agent, co-dissolving with polyhydric phosphate in ice bath, and regulating pH to 6.8-7.4 with saturated disodium biphosphate solution after reaction, so as to obtain biodegradable sol-gel conversion system for injection. The material can form gel at 37 deg.c, is temperature sensitive and the added polyenol has the functions of raising hydrophobic performance, raising gel strength, etc.

Description

technical field [0001] The invention relates to a biodegradable material with reverse temperature sensitivity and a preparation method thereof. The material will have good application prospects in the fields of drug delivery system, cell embedding, biological tissue engineering and medical equipment. Background technique [0002] The successful development of new materials is of great significance to the rapid development of medical technology. In particular, biopolymer materials are widely used in the field of drug delivery technology and tissue engineering. Traditionally used materials, such as silicone rubber, are not biocompatible and biodegradable, so they have certain toxicity and irritation; at the same time, they are used as carriers of drug delivery materials, especially in implanted drug delivery systems When, it is inevitable to use surgery for implantation, which is the biggest shortcoming of this type of system. At present, most studies use synthetic temperatu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/24C08L5/00C08L29/02A61K31/738A61K9/00
Inventor 昝佳林莹蒋国强丁富新
Owner TSINGHUA UNIV
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