Technical method for synthesizing beta p-hydroxy phenethyl alcohol

A technique for the synthesis of p-hydroxyphenylethyl alcohol, applied in chemical instruments and methods, preparation of organic compounds, organic chemistry, etc., can solve the problems of long synthetic process route, poor process practicability, low production cost, etc., and achieve the synthetic process route Short, low production cost, high production efficiency
CN100432035CInactive Publication Date: 2008-11-12SHENYANG LIGONG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHENYANG LIGONG UNIV
Publication Date
2008-11-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

This invention discloses a method for synthesizing beta-p-hydroxyphenylethanol from phenol and acetic anhydride by esterification, halogen-alkylation and hydrolysis. Since the O atom on phenolic hydroxyl has a high electronegativity, it is easily subjected to alkylation reaction. To avoid the reaction, esterification is employed to preotect the O atom and phenyl acetate. Then 1,2-dihaloethylene is added on the benzene ring of phenyl acetate to obtain (4-beta-haloethyl)phenyl acetate. The protection groups are removed by hydrolysis to obtain beta-p-hydroxyphenylethanol. The method has such advantages as short synthesis route, mild reaction conditions, high efficiency, high yield (up to 93%), and abundant raw material resources.
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Description

technical field

[0001] The invention belongs to fine chemical synthesis technology, in particular to a process for preparing β-p-hydroxyphenethyl alcohol. Background technique

[0002] β-Hydroxyphenethyl alcohol is an inhibitor of active oxides. It can inhibit the damage of peroxides to DNA, reduce the oxidation in bone marrow cells, and protect the production of red blood cells in bone marrow. β-Hydroxyphenethyl alcohol is also an important pharmaceutical intermediate, which can be used to synthesize many useful drugs, such as: Metoprolol (Metoprolol), also known as Metoprolol, is used for the treatment of hypertension, angina pectoris, Arrhythmia and myocardial infarction can also be used to treat hyperthyroidism and migraine; Betaxolol, also known as Betaxolol, can treat high blood pressure and open-angle glaucoma; maltine, an active ingredient of barley malt , can digest and neutralize food accumulation, not thinking about eating, abdominal distension and breast swellin...

Claims

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