Medical implantation material capable of by degraded by body fluid and its preparing process

A technology for implants and body fluids, applied in prosthetics, medical science, electrolytic coatings, etc., to achieve high support strength characteristics, good tissue compatibility and blood compatibility

Active Publication Date: 2007-08-15
PEKING UNIV
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  • Description
  • Claims
  • Application Information

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  • Medical implantation material capable of by degraded by body fluid and its preparing process
  • Medical implantation material capable of by degraded by body fluid and its preparing process
  • Medical implantation material capable of by degraded by body fluid and its preparing process

Examples

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Embodiment 1

[0054] Embodiment 1, preparation and performance test of medical Mg-Ca alloy implant

[0055] With pure Mg (purity is 99.9%), pure Ca (purity is 99.9%) (purchased from Beijing Cui Berlin Nonferrous Metals Technology Development Center) as raw materials, according to different mass ratios (magnesium calcium mass ratio is 99:1, 95:5 respectively) or 80:20) mixed in proportion, in CO 2 +SF 6 Under the protection of atmosphere, smelt at 700-720°C. After the raw materials are fully melted, after 10 minutes of heat preservation, the circulating water is rapidly cooled to obtain a Mg-Ca alloy ingot (Mg-1Ca (mass ratio of magnesium to calcium is 99:1), Mg- 5Ca (mass ratio of magnesium to calcium is 95:5), Mg-20Ca (mass ratio of magnesium to calcium is 80:20)) (Figure 1), the phase composition is detected by X-ray diffraction (XRD), and some results are shown in Figure 2, The results show that the second phase Mg does not appear when the mass content of calcium increases to 1% (Mg-1C...

Embodiment 2

[0065] Example 2. Preparation of biodegradable medical implant and its cytotoxicity test

[0066] Using pure Mg (purity 99.9%) and pure Ca (purity 99.9%) (purchased from Beijing Cuibin Nonferrous Metals Technology Development Center) as raw materials, the mass ratio of magnesium to calcium is 99:1, mixed in CO2+SF6 atmosphere Under protection, smelt at 700-720°C. After the raw materials are fully melted, keep warm for 10 minutes, and then cool quickly with circulating water to prepare Mg-Ca alloy ingot Mg-1Ca (mass ratio of magnesium to calcium is 99:1).

[0067] Sterilize and sterilize 5 magnesium-calcium alloy blocks prepared above with a length, width, and thickness of 10, 10, and 1 mm respectively, and place them in a sterile culture bottle. The volume ratio of 1640 culture solution is 3cm 2 Add RPMI 1640 culture solution at a ratio of / ml, place in 37°C, 95% relative humidity, and 5% CO2 incubator for 72 hours to obtain the original solution of magnesium-calcium alloy ex...

Embodiment 3

[0069] Example 3. Preparation of biodegradable medical implant and its mechanical properties test

[0070] The rapid solidification Mg-Ca alloy (Mg-2Ca (the mass percent composition of magnesium is 98 ± 0.3%, the mass percent composition of calcium is 2 ± 0.3%), Mg-5Ca (magnesium mass percent composition) is prepared by high vacuum rapid quenching system. The mass percent composition is 98±0.3%, the mass percent composition of calcium is 5±0.3%), Mg-5Ca-5Zn (the mass percent composition of magnesium is 98±0.3%, the mass percent composition of calcium is 5±0.3%) 0.3%, the mass percentage of Zn is 5 ± 0.3%)) thin strip, the specific method is: after mixing the raw materials according to the stated ratio, use a high vacuum rapid quenching system to prepare rapid solidification Mg-2Ca, Mg-5Ca or Mg- 5Ca-5Zn thin strip, the parameters are feed amount 2~8g, induction heating power 3-7kW, distance between nozzle and roller 0.80mm, injection pressure 0.1MPa, roller speed 2000r / mln and...

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Abstract

This invention relates to a body fluid degradative medicinal implant and its preparation method. The implant is prepared from Mg-Ca rafting wherein, Mg content is 7-10 weight parts (excluding 10); and Ca content is 0-3 (excluding 0). It is proven by in vitro and in vivo studies, the implant has the advantages of no toxicity, and good organization consistency and sanguis consistency.

Description

technical field [0001] The invention relates to a body fluid degradable medical implant and a preparation method thereof. Background technique [0002] At present, medical biodegradable materials are mainly biodegradable polymer materials and biodegradable ceramics, synthetic biodegradable polymer materials, including polyglycolic acid (PGA), polylactic acid (PLA), polycaprolactone (PCL), polycyanoacrylate (PACA), polydioxanone and its copolymers, polyanhydrides, polyphosphazenes, amino acid polymers, poly-beta-hydroxybutyrate and hydroxyvaleric acid Esters, etc.; natural biodegradable polymer materials, including natural polysaccharide materials (cellulose, chitin) and natural protein materials (collagen, fibrin); widely used biodegradable ceramics include hydroxyapatite, α - Tricalcium phosphate, beta-tricalcium phosphate and oxytetracalcium phosphate. Although biodegradable polymer materials can be completely absorbed by the human body, their strength is low and it is d...

Claims

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Application Information

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IPC IPC(8): A61L27/42A61L31/12C23C4/10C25D13/02C25D11/02C23C4/134
Inventor 郑玉峰顾雪楠成艳李超
Owner PEKING UNIV
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