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Porous film material fixed with heparin on surface, its preparing method and use

A surface-fixed, porous membrane technology, applied in chemical instruments and methods, membrane technology, semi-permeable membrane separation, etc., can solve the problems of weak heparin, complex preparation process of adsorbed particles, etc., achieving good production repeatability and easy large-scale production. The effect of a wide range of production and material sources

Inactive Publication Date: 2007-08-29
SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

From the perspective of application effect, although the static adsorption results are good, the preparation process of adsorption particles is relatively complicated, and many toxic reagents (such as glutaraldehyde) used in the preparation process may remain in the resin. In addition, this method uses electrostatic adsorption mechanism to fix the particles. Heparin is not strong

Method used

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  • Porous film material fixed with heparin on surface, its preparing method and use
  • Porous film material fixed with heparin on surface, its preparing method and use
  • Porous film material fixed with heparin on surface, its preparing method and use

Examples

Experimental program
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Effect test

Embodiment 1

[0096] Cut the medical polypropylene non-woven fabric with an average pore size of 0.1 μm into 5cm×5cm 2 The samples were ultrasonically cleaned in acetone and water for 15 to 30 minutes, and dried in vacuum for later use. Then, soak the above-mentioned sample in an aqueous solution containing 10% (mass percentage) of acrylic acid monomer, which additionally contains 1.0% ferrous sulfate polymerization inhibitor and 0.5% sulfuric acid catalyst. After soaking for 24 hours, place the sample in 60 In the radiation field of Co γ-ray source, the total cumulative irradiation dose is controlled to 30kGy. After the above-mentioned irradiation treatment sample was taken out, it was washed, dried, weighed and calculated to obtain a copolymerization grafting rate of acrylic acid of 30 wt%, and the corresponding surface carboxyl group content of the obtained porous membrane carrier material was 25 μmol / cm 2 , ATR-FITR infrared spectrum analysis found that the sample was at 1700cm -1A ne...

Embodiment 2

[0098] Cut the 0.45μm medical polypropylene non-woven fabric into 5cm×5cm 2 The samples were ultrasonically cleaned in acetone and water for 15 to 30 minutes, and dried in vacuum for later use. The above samples were then soaked in an aqueous solution containing 15% acrylic acid monomer. The solution contains 0.5% ferrous sulfate polymerization inhibitor and 1.0% sulfuric acid catalyst at the same time. After soaking for 24 hours, the sample is placed in 60 In the radiation field of the Co γ-ray source, the total cumulative irradiation dose is controlled to be 20kGy. After taking out the above-mentioned radiation treatment sample, wash, dry, weigh and calculate the copolymerization grafting rate of acrylic acid to be 84wt%, quantitative titration surface carboxyl content is 70μmol / cm 2 . ATR-FITR infrared spectrum analysis found that at 1700cm -1 A strong absorption peak appears at , corresponding to the characteristic absorption signal of the carboxyl group, indicating th...

Embodiment 3

[0100] Cut the 1.0μm medical polypropylene non-woven fabric into 5cm×5cm 2 The samples were ultrasonically cleaned in acetone and water for 15 to 30 minutes, and dried in vacuum for later use. The above samples were then soaked in an aqueous solution containing 15% acrylic acid monomer. Contain 0.5% ferrous sulfate polymerization inhibitor, 0.5% sulfuric acid catalyst simultaneously in the solution, after soaking for 24 hours, put the sample in 60 In the Co γ-ray source radiation field, the total cumulative irradiation dose is controlled to be 30kGy. After taking out the above-mentioned irradiation treatment sample, wash, dry, weigh and calculate the copolymerization grafting rate of acrylic acid to be 75wt%, quantitative titration surface carboxyl content is 96μmol / cm 2 . ATR-FITR infrared spectrum analysis found that at 1700cm -1 A strong absorption peak appears at , corresponding to the characteristic absorption signal of the carboxyl group, indicating that the polyacry...

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Abstract

This invention aims at providing a plasma lipid composition selective adsorption separation porous membrane carrier materials, preparation methods and related applications. The porous membrane carrier used the average pore size of 0.05 m ~ 100 u medical nonwoven polymer as the starting raw materials, through a total of 60 Co-ray irradiation grafting copolymerization polyacrylic acid surface modification, it further fixed the cholesterol ligand by carboxyl of 1 - (3 - dimethyl amino-propyl ) -3 - ethyl activated carbon Diimide and biocompatibility ligand adsorption of heparin covalent coupling, finally get the polymer porous membrane carrier materials of plasma lipid selective adsorption separation ability. The invention related to the preparation method is simple, safe, effective and easy to promote large-scale production. With good material blood compatibility, it can be used as a plasma lipid composition adsorption separation of hyperlipidemia, dynamic perfusion of clinic high plasma patients' blood purification and waste blood separation renewable auxiliary materials.

Description

technical field [0001] The invention provides a new polymer porous membrane carrier material with heparin ligand immobilized on the surface, a preparation method and its application in adsorption and separation of plasma lipid components. The polymer porous membrane material provided by the invention relates to a carrier material for selective adsorption and separation of plasma lipid components in blood purification and perfusion treatment of patients with clinical hyperlipidemia, and belongs to the field of organic biomedical materials and medical device auxiliary materials. The new type of polymer porous membrane carrier material with immobilized heparin ligand on the surface involved in this invention is prepared from medical grade polymer non-woven fabrics with different average pore sizes. 60 Co γ-ray co-irradiation graft copolymerization acrylic acid modification and subsequent surface coupling immobilization of heparin adsorption ligand and other series of preparation ...

Claims

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Application Information

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IPC IPC(8): B01D67/00A61M1/36B01J20/26B01J20/28B01D71/78
Inventor 曹阿民侯小东张涛
Owner SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI
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