P-aminoanisole electrochemical synthesis method

Abstract

Provided is an electrochemical synthetic method of aminoanisole, belonging to the technical field of electrochemistry. The method needs to be accomplished in a two-chamber electrolysis bath which is separated by employing a cation-exchange membrane, a copper sheet is taken as a negative electrode, a ruthenium net is taken as a positive electrode, a saturated calomel electrode is taken as a reference electrode, the negative electrode and the reference electrode are installed inside a cathode chamber of the electrolysis bath, and the positive electrode is installed inside an anode chamber of the electrolysis bath. Methanol is taken as solvent, sulphuric acid is taken as supporting electrolyte, paranitroanisole is taken as electrolytic reaction substrate, the solvent and the solution of supporting electrolyte are injected into the cathode chamber and the anode chamber, and the electrolytic reaction substrate is injected into the cathode chamber. The electrolyzation is performed within a condition of normal temperature and pressure and a condition that the negative electrode is added with a certain constant voltage relative to the reference electrode, and the constant voltage is between -0.4 to -0.6 V. After the electrolyzation is finished, the electrolyte is post-processed to obtain the product of paraphenetidine with the production ratio between 24.5-63.3%. The method has the advantages of simple requirement, mild reaction conditions, easy preparation of the electrodes, low price, small pollution in the process of reaction and the like, and is a greening production line.

Description

technical field [0001] The invention relates to an electrochemical synthesis method of p-aminoanisole, which belongs to the technical field of electrochemistry. Background technique [0002] P-aminoanisole, also known as p-methoxyaniline, commonly known as p-anisidine, molecular formula C 7 h 9 NO, white crystal, melting point 57.2°C, boiling point 243°C, relative density 1.071, refractive index 1.5559 (57°C), easily soluble in ethanol, methanol, benzene, ether and chloroform, hardly soluble in water. p-Aminoanisole is mainly used in the dye industry to prepare ice dyes, disperse dyes, vat dyes, cationic dyes, chromophores and naphthols, etc. In the pharmaceutical industry, it is used to produce adipine, primaquine, indomethacin Wait. [0003] The existing methods for producing p-aminoanisole are mainly organic synthesis methods, including 1. Nitrobenzene method, at 75-125°C and 0.6-1.5MPa, using precious metals as catalysts, sulfuric acid, methanol or dimethyl Sulfoxide...

AI Technical Summary

Problems solved by technology

The p-nitroanisole reduction method uses sodium sulfide, hydrazine hydrate, etc. as catalysts, and a large amount of lye, sulfur-containing wastewater, etc. are produced, causing serious pollution to the environment; or expensive precious metal catalysts are used, and the reaction conditions are harsh

[0004] The traditional synthesis method of p-aminoanisole either uses expensive noble metal catalysts, or produces a large amount of waste during the reaction process, or requires harsh reaction conditions. Therefore, the traditional production method has no great development prospects