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Problems solved by technology
[0005] A problem with these radiopharmaceuticals is that they are prone to radioactive decomposition, with a progressive loss of purity
Method used
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Embodiment 1～12 and comparative example 1
[0041] Prepared according to the following procedure 18 F-FDG solution
[0042] rich first 18 The target water of O is exposed to proton bombardment to contain [ 18 F] Fluoride ions are obtained in the form of target water [ 18 F] Fluoride ion. The target water is then passed through a strong anion exchange resin to [ 18 F] Fluoride ions are absorbed and collected onto the resin. Aqueous potassium carbonate solution was then passed through to elute [ 18 F] Fluoride ion.
[0043] Next, add the [ 18 F] An acetonitrile solution of KRYPTOFIX 222 (trade name, manufactured by Merck & Co., Inc.) was added to the eluent of fluoride ions, and the mixture was heated and distilled to dryness. Then, a solution of TATM in acetonitrile was added thereto, and the mixture was heated for 18 F logo. Next, the product was deprotected by hydrolysis with hydrochloric acid. The resulting mixture was purified using an ODS column and an alumina column to obtain 18 F-FDG stock solution (ra...
Embodiment 13～18 and comparative example 2
[0061] Repeat the same process as Comparative Example 1 and Examples 1 to 12 to obtain 18 F-FDG stock solution (radioactivity=126.3 GBq). Towards 18 Physiological saline was added to the F-FDG stock solution for dilution, so that the resulting solution had 92.5 MBq / mL 4.5 hours after preparation. formed 18 F-FDG solution.
[0062] obtained from the above 18 To 2 mL of the F-FDG solution, solutions having different concentrations of mannitol shown in Table 3 were added in the amounts shown in Table 3, and mixed at room temperature to prepare each sample solution.
[0063] table 3
[0064] Addition amount of mannitol solution and physiological saline used in the samples of Examples 13 to 18, and mannitol concentration in the obtained samples
[0065]
[0066] For the samples obtained above, in the preparation 18 Immediately after the F-FDG solution (comparative example 2 only), 4.5 hours and 8.5 hours after preparation, TLC analysis was performed under the following co...
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PUM
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Abstract
In a radioactive diagnostic imaging agent comprising a radioactive halogen-labeled compound as an active ingredient, to prevent the radiation degradation of the active ingredient to increase the stability of the radioactive diagnostic imaging agent. A biologically acceptable saccharide or sugar alcohol is added to the radioactive diagnostic imaging agent in an amount effective for the prevention of the radiation degradation. The amount of the saccharide or sugar alcohol to be added is preferably 10 (mmol / L) / GBq / mL or more, more preferably 50 (mmol / L) / GBq / mL or more. The saccharide is preferably selected from the group consisting of erythrose, threose, ribose, arabinose, xylose, lyxose, allose, altrose, glucose, mannose, gulose, idose, galactose, talose, erythrulose, ribulose, xylulose, psicose, fructose, sorbose and tagatose. The sugar alcohol is preferably selected from the group consisting of erythritol, xylitol, sorbitol and mannitol.
Description
technical field [0001] The present invention relates to a radiodiagnostic imaging agent comprising a radioactive halogen labeling compound as an active ingredient. More specifically, the present invention relates to radiodiagnostic imaging agents in which the radiolysis of radiohalogen-labeled organic compounds is inhibited by the addition of sugars or sugar alcohols. Background technique [0002] Nuclear medicine examinations represented by positron emission tomography (hereinafter referred to as "PET") and single photon emission computed tomography (hereinafter referred to as "SPECT") are effective in diagnosing various diseases including cancer. These techniques involve administering to a patient an agent labeled with a radioisotope (hereinafter referred to as "radiopharmaceutical") and then detecting gamma rays emitted directly or indirectly from the administered agent. Compared with other inspection methods, nuclear medicine examination has the following characteristic...
Claims
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