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Medical wound dressing with anti-bacterial nanometer particulate

A wound dressing and antibacterial drug technology, applied in the field of medical wound dressings loaded with antibacterial drug nanoparticles, to achieve good slow-release effect and good water vapor transmission rate

Inactive Publication Date: 2008-07-23
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The Chinese patent with the publication number CN101053668 proposes a nano-calamine composite hydrogel wound dressing, which has antibacterial, antipruritic, astringent, and wound-healing effects due to containing nano-calamine, but is limited to nano-scale Calamine

Method used

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  • Medical wound dressing with anti-bacterial nanometer particulate

Examples

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Embodiment 1

[0026] Preparation of erythromycin nanoparticles: 0.5-1.5g of acrylic acid (Aac) was dissolved in 5mL of pH8 phosphate buffer, 0.25g of glyceryl methacrylate modified dextran (dex-GMA), 20mg of erythromycin Sulfate, 3mg ammonium persulfate, fully dissolved, set aside.

[0027] Add 30 mL of pH 8 phosphate buffer solution and 0.1 mL of Tween-80 into the three-necked flask, stir, and nitrogen protection for 10 min, then add the above-mentioned standby solution dropwise, and nitrogen protection at 70°C for 5 h. The reaction solution was cooled to room temperature, dialyzed, and freeze-dried.

[0028] Konjac glucomannan was dissolved in double-distilled water to make a solution with a concentration of 1 wt%, filtered to remove insoluble impurities, and 20 mg of erythromycin nanoparticles were added while stirring to mix evenly, and chitosan was dissolved in 0.8% acetic acid solution to prepare into a solution with a concentration of 1 wt%. Get 24mL of chitosan solution and 6mL of...

Embodiment 2

[0030] The difference between this example and Example 1 is that cornstarch is dissolved in double-distilled water to make a solution with a concentration of 1 wt%, and heated while stirring at a constant speed to form a gel, and 0.2 g of chlorhexidine hydrochloride drug-loaded nanoparticles are added. Mix with chitosan solution (concentration is with embodiment 1), other is with embodiment 1.

Embodiment 3

[0032] The preparation method of this example is the same as that of Example 1, except that the 1wt% konjac glucomannan solution is replaced by a 5% gelatin solution.

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Abstract

The invention discloses a medical wound dressing which is loaded with antibiotic nanometer particles and which is in a spongy state when being dried and in a gel state after absorbing the moisture; the medical wound dressing is fixed in a spongy membrane prepared by chitosan and natural high molecular polymers and derivatives of the chitosan with the proportion of 10 to 19 percent of the spongy membrane and natural polymers by drug-loading nanometer particles; the drug-loading nanometer particles contains antibiotics with the particle size of 100nm to 1000nm, the encapsulation rate of 50 to 98 percent and the drug-loading rate of 5 to 60 percent and the weight percentage of 2 to 10 percent of the drug-loading nanometer particles in the wounding dressing. Combing the sustained and controlled release characteristic and the advantage of polysaccharide membrane, the invention has high water absorbability, air permeability, moisture permeability and good biological compatibility can keep the wound physiological moisture environment and promote the wound to recover and has hemostatic effect; at the same time, the invention has good slow release performance for the antibiotics, can prevent the infection of the wound and accelerate the recovery, thus being suitable for a plurality of wounds such as the traumas, burns and ulcers.

Description

technical field [0001] The invention relates to a medical wound dressing, in particular to a medical wound dressing loaded with antimicrobial drug nanoparticles. The wound dressing combines the characteristics of slow and controlled release of drug-loaded nanoparticles and the advantages of polysaccharide film formation, and has high water absorption, Air permeability and moisture permeability can maintain the physiological moist environment of the wound surface, promote wound healing and hemostasis, and have good slow-release properties for antibacterial drugs, which can prevent wound infection and accelerate recovery. It is suitable for wounds, burns, ulcers and other wounds. Background technique [0002] Wound healing is a dynamic process, so the requirements for wound dressings will change as the healing process progresses. Effective wound dressings can not only isolate the wound from the outside world, but also remove wound exudate, provide a moist microenvironment tha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/32A61L15/28A61L15/44A61L15/60
Inventor 吴红张慧范黎李飞
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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