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Water-soluble cationic polymer adsorption material and applications thereof

A water-soluble cation and adsorption material technology, which is applied in the field of biomedical materials, can solve the problems of reduced ability to remove pathogenic factors, expensive treatment costs, and complicated equipment and devices, so as to improve blood compatibility and avoid non-specific adsorption. fast effect

Inactive Publication Date: 2008-07-23
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] 1) The solid adsorbent for hemoperfusion binds to the pathogenic factor through electrostatic interaction or hydrophobic interaction. Due to the complex composition of blood, when the solid adsorbent comes into contact with blood, some essential components such as plasma proteins can also be adsorbed to the blood through the above two effects. The surface of the solid adsorbent, on the one hand, leads to a significant reduction in the ability to remove pathogenic factors in the blood, and on the other hand, the removal of useful components in the blood also leads to increased side effects of treatment; 2) The treatment equipment is complicated and the treatment cost is expensive
Hemoperfusion systems generally require two sets of plasma separators and adsorption columns, while MARS and Biologic-DT systems are more complicated, resulting in higher treatment costs

Method used

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  • Water-soluble cationic polymer adsorption material and applications thereof
  • Water-soluble cationic polymer adsorption material and applications thereof
  • Water-soluble cationic polymer adsorption material and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1. Synthesis of water-soluble cationic starch and its application in blood purification

[0031] The first step is to prepare the adsorbent material

[0032] Weigh 10 grams of starch with a viscosity average molecular weight ranging from 400 to 500KD and put it into a beaker, add 6ml of water to it, then add 5 grams of sodium hydroxide to the starch, and stir with an electric stirrer to make the sodium hydroxide and starch Mix well. Then add 28 grams of 2,3-epoxypropyltrimethylammonium chloride, add it to the mixture of starch and sodium hydroxide that has been stirred, make it evenly mixed, and then react at 70°C for 4 hours to obtain quaternary ammonium The crude starch product was washed with 80% ethanol, suction filtered and dried to obtain pure quaternized starch. The reaction formula is as follows:

[0033]

[0034] n=2469~3087 (corresponding to the starch molecular weight range of 400~500KD).

[0035] The second step, the preparation of dialysis...

Embodiment 2～6

[0039] The discarded plasma exchanged from patients with severe hepatitis was subjected to in vitro simulated adsorption dialysis experiments. The initial concentrations of bilirubin, bile acids, blood ammonia, creatinine, and urea in plasma were 248 mg / L, 203.5 μmol / L, and 97.55 μmol / L, respectively. , 287μmol / L, 13.65mmol / L. Nipro triacetate hollow fiber dialyzer SUREFLUX-130G was selected; 40ml of plasma from patients with severe hepatitis circulated in the hollow fiber membrane in the hemodialyzer at a flow rate of 100ml / min; the prepared adsorption dialysate with a concentration of 0.1% had a volume 200ml, through the outer cavity of the hemodialyzer, the flow rate is 100ml / min, and exchange solute with the blood in the hollow fiber membrane, the adsorption dialysis time is 4 hours. The experimental results show that the removal rates of various toxins are 23.8% for bilirubin, 49.6% for bile acid, 23.6% for blood ammonia, 45.6% for creatinine, and 17.7% for urea. Example...

Embodiment 7

[0043] Embodiment 7. chitosan and 2,3-epoxypropyltrimethylammonium chloride reaction synthesis adsorption material and its application

[0044] The first step is to prepare the adsorbent material

[0045] Weigh 10 grams of chitosan with a viscosity-average molecular weight range of 90 to 100KD, add 300ml of water, 30 grams of 2,3-epoxypropyltrimethylammonium chloride, and react at 75°C for 10 hours, and the reaction product Precipitate with ethanol or acetone, wash with 80% aqueous ethanol, filter with suction and dry to obtain a pure product. The reaction formula is as follows:

[0046]

[0047] n=559-622 (corresponding to chitosan molecular weight range of 90-100KD).

[0048] The second step, the preparation of dialysis adsorption solution

[0049] 1 gram of 2-hydroxypropyltrimethylammonium chloride chitosan was dissolved in 100 ml of bicarbonate dialysate, and the concentration of 1% (w / v) was configured as an adsorption dialysate.

[0050] The third step, hemoadsorp...

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Abstract

The invention relates to a water soluble cationic polymer adsorption material in the biomedical material field and the application thereof, which contains the quaterisation reaction synthesis of natural polysaccharides with amino groups and hydroxyls and the derivatives thereof or chemosynthetic polymers. The invention is characterized in that the molecule of the polymer adsorption material has a structure in formula I: in the formula, R is selected from the natural polysaccharides with amino groups and hydroxyls and the derivatives thereof or the chemosynthetic polymers, the molecular weight of which is from 6 KD to 500 KD; X is selected from a C0 to C6 paraffinic chain with O atoms, N atoms or OH groups; R1, R2 and R3 are selected from a C1 to C4 alkyl group. After the adsorption material is dissolved in a medical dialysis solution, the material can be applied to a blood purification treatment for severe hepatitis patients. The invention has the advantages of removing protein-bound toxin and water soluble toxin molecule at the same time, low cost which is only about one tenth of that of a molecular adsorbent recirculating system and little nonspecific adsorption to plasma protein.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a water-soluble cationic polymer adsorption material used for removing various small and medium molecular toxins in blood, and a method for performing adsorptive dialysis on blood by using the adsorption material. Background technique [0002] Severe hepatitis, liver insufficiency and liver failure caused by various reasons are very common in our country. Liver failure, whether caused by acute onset or acute exacerbation of chronic liver disease, is always a clinical syndrome that seriously threatens the lives of patients. Its main manifestation is the accumulation of a large number of metabolic toxins in the body, including blood ammonia, bilirubin, bile acids, etc., which can cause various serious complications. A very important fraction of these metabolic toxins are negatively charged small and medium molecules. [0003] At present, blood purification therapy ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01J20/285A61M1/38
Inventor 贾凌云王智田磊徐文学谢健
Owner DALIAN UNIV OF TECH
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