Water-soluble cationic polymer adsorption material and applications thereof

A water-soluble cation and adsorption material technology, which is applied in the field of biomedical materials, can solve the problems of reduced ability to remove pathogenic factors, expensive treatment costs, and complicated equipment and devices, so as to improve blood compatibility and avoid non-specific adsorption. fast effect
CN101224413AInactive Publication Date: 2008-07-23DALIAN UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
DALIAN UNIV OF TECH
Publication Date
2008-07-23
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a water soluble cationic polymer adsorption material in the biomedical material field and the application thereof, which contains the quaterisation reaction synthesis of natural polysaccharides with amino groups and hydroxyls and the derivatives thereof or chemosynthetic polymers. The invention is characterized in that the molecule of the polymer adsorption material has a structure in formula I: in the formula, R is selected from the natural polysaccharides with amino groups and hydroxyls and the derivatives thereof or the chemosynthetic polymers, the molecular weight of which is from 6 KD to 500 KD; X is selected from a C0 to C6 paraffinic chain with O atoms, N atoms or OH groups; R1, R2 and R3 are selected from a C1 to C4 alkyl group. After the adsorption material is dissolved in a medical dialysis solution, the material can be applied to a blood purification treatment for severe hepatitis patients. The invention has the advantages of removing protein-bound toxin and water soluble toxin molecule at the same time, low cost which is only about one tenth of that of a molecular adsorbent recirculating system and little nonspecific adsorption to plasma protein.
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Description

technical field

[0001] The invention belongs to the field of biomedical materials, and in particular relates to a water-soluble cationic polymer adsorption material used for removing various small and medium molecular toxins in blood, and a method for performing adsorptive dialysis on blood by using the adsorption material. Background technique

[0002] Severe hepatitis, liver insufficiency and liver failure caused by various reasons are very common in our country. Liver failure, whether caused by acute onset or acute exacerbation of chronic liver disease, is always a clinical syndrome that seriously threatens the lives of patients. Its main manifestation is the accumulation of a large number of metabolic toxins in the body, including blood ammonia, bilirubin, bile acids, etc., which can cause various serious complications. A very important fraction of these metabolic toxins are negatively charged small and medium molecules.

[0003] At present, blood purification therapy ...

Claims

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