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Sustained-release analgesia medical dressing and preparation method thereof

A slow-release, medical technology, applied in the field of medicine, can solve the problem of difficult control of the dosage, and achieve the effects of no sensitization, easy industrial production, and simple preparation method.

Inactive Publication Date: 2008-10-15
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its biggest advantage is that it will not accumulate in the body, and the analgesic effect will take effect quickly and the drug effect is strong. However, because it contains an ester structure, it is easily metabolized by the esterase in the body, and the dosage is not easy to control. Long-term continuous intravenous infusion or micropump infusion of REM can easily cause phlebitis and produce obvious inhibition of respiratory system and cardiovascular system, etc.
Therefore, REM has not been widely used in the treatment of traumatic incisions and postoperative incision pain.

Method used

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  • Sustained-release analgesia medical dressing and preparation method thereof
  • Sustained-release analgesia medical dressing and preparation method thereof
  • Sustained-release analgesia medical dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] 1. The first preparation method

[0051] (1) Preparation of remifentanil polymer sustained-release analgesic drug

[0052] A. Raw materials

[0053] 6 grams of caprolactone, 0.008 grams of remifentanil (REM), 6 grams of toluene, 0.006 grams of aluminum isopropoxide;

[0054] B. Polymerization reaction

[0055] First put toluene into a reaction kettle with a stirrer, then add caprolactone and aluminum isopropoxide to toluene, under the protection of argon, react at normal pressure and 30°C for 40 hours, then add REM, , 30 ° C for 4 hours, the whole reaction is carried out under stirring;

[0056] C. Collect the product from the reaction mixture

[0057] After the polymerization reaction is completed, remove the solvent by distillation under reduced pressure, cool to room temperature, and then dissolve the product with chloroform, then add cold methanol at 4°C for precipitation (the number of precipitation is at least 3 times), and the white product obtained after suc...

Embodiment 2

[0078] 1. The first preparation method

[0079] (1) Preparation of remifentanil polymer sustained-release analgesic drug

[0080] A. Raw materials

[0081] 6 grams of caprolactone, 0.008 grams of remifentanil (REM), 9 grams of tetrahydrofuran, 0.4 grams of zinc octanoate;

[0082] B. Polymerization reaction

[0083] First put tetrahydrofuran into a reaction kettle with a stirrer, then add caprolactone and zinc octanoate into tetrahydrofuran, under the protection of helium, react at normal pressure and 130°C for 4 hours, then add REM, ℃ for 1.5 hours, and the whole reaction was carried out under stirring;

[0084] C. Collect the product from the reaction mixture

[0085] After the polymerization reaction is completed, remove the solvent by distillation under reduced pressure, cool to room temperature, and then dissolve the product with chloroform, then add cold methanol at 4°C for precipitation (the number of precipitation is at least 3 times), and the white product obtaine...

Embodiment 3

[0106] 1. The first preparation method

[0107] (1) Preparation of remifentanil polymer sustained-release analgesic drug

[0108] A. Raw materials

[0109] 6 grams of caprolactone, 0.008 grams of remifentanil (REM), 9 grams of toluene, 0.002 grams of iron acetate;

[0110] B. Polymerization reaction

[0111] First put toluene into a reaction kettle with a stirrer, then add caprolactone and iron acetate into toluene, under the protection of argon, react at normal pressure and 120°C for 12 hours, then add REM, ℃ for 2 hours, and the whole reaction was carried out under stirring;

[0112] C. Collect the product from the reaction mixture

[0113] After the polymerization reaction is completed, remove the solvent by distillation under reduced pressure, cool to room temperature, and then dissolve the product with chloroform, then add cold methanol at 4°C for precipitation (the number of precipitation is at least 3 times), and the white product obtained after suction filtration i...

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Abstract

The invention relates to medical slow-released analgesic dressing which comprises the following components and contents: remifentanil polymer slow-released analgesic drug is 2 to 4 parts by weight; gelatin is 10 to 20 parts by weight; the remifentanil polymer slow-released analgesic drug is obtained from the reaction between the remifentanil which is used as polymerization termination agent and caprolactone; the gelatin has the prescription that glycerin is 4 to 8 parts by volume, whiteruss is 3 to 6 parts by weight, polyvinyl alcohol is 2 to 4 parts by weight, and purified water is 25 to 50 parts by volume. The medical slow-released analgesic dressing has the preparation method and technical steps as follows: (1) the remifentanil polymer slow-released analgesic drug is prepared; (2) the gelatin is prepared; (3) the remifentanil polymer slow-released analgesic drug which is prepared in the step (1) and the gelatin which is prepared in the step (2) are stirred and mixed for 1 to 2 hours under the normal atmosphere to prepare the medical slow-released analgesic dressing, wherein, the remifentanil polymer slow-released analgesic drug is 2 to 4 parts by weight and the gelatin is 10 to 20 parts by weight, and the temperature is 40 to 60 DEG C.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a sustained-release analgesic medical dressing and a preparation method thereof. Background technique [0002] With the understanding of the relationship between dressings and wound healing, a variety of new medical dressings, such as films and hydrocolloid dressings, that can maintain the wound in a closed and close to physiological environment have emerged. However, such medical dressings cannot control the degree and duration of wound pain after traumatic incisions and surgical procedures. [0003] Studies have shown that effective opioid analgesic treatment can reduce the stress response caused by traumatic incision and postoperative incision pain, stabilize the patient's internal environment, reduce postoperative anxiety, stabilize mood, and benefit sleep and rest. Promote the early recovery of patients after surgery. In addition, opioid analgesic treatment can enhance th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/34A61L15/44A61K31/765
Inventor 方华王泉云陈荣义李华凤李昌熙刘进
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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