Method for preparing 2-amido-1-alkyl alcohol and catalyst preparation method

Abstract

The invention relates to methods for preparing 2-amino-1-alkyl alcohol and catalyst. The solid catalyst is filled in a single-tube type or double-tube type fixed bed reactor, the temperature in a preheater and the reactor is kept between 130 to 250 DEG C, the hydrogen pressure is kept between 1.0 to 10.0MPa; 1, 2-diol solution with the volume ratio of 10 to 30 percent and ammonia gas are led into the fixed bed reactor from the upper end, the mol ratio between 1, 2-diol and ammonia gas is 1:3 to 1:15, the volume airspeed of the 1, 2-o-diol solution is 30 to 300h<-1>, the obtained liquid is added with methanol for being regulated to homogeneous phase, and transferred into a still after being filtered, and then rectified to obtain the product after the solvent is removed by evaporation. The preparation method of the catalyst adopts the immersion method or the extruding method. The quality of the products of the invention meets the standards of the first class of the industrial products, the content of 2-amino-1-butyl is equal to or more than 99.0 percent; the prepared catalyst for catalysis and amination has long service life; the technology is simple and suitable for continuous industrial production; the cost is low, and the economic benefit is high.

Description

technical field [0001] The invention relates to a method suitable for preparing 2-amino-1-alkanol through selective catalytic dehydrogenation, amination and catalytic hydrogenation with 1,2-vicinal diol as the main raw material and a catalyst preparation method. Background technique [0002] 2-Amino-1-alkyl alcohol compounds are a class of compounds that are widely used, especially as drugs or pharmaceutical intermediates. For example, (S)—(+)—2-aminopropanol is a key intermediate for the synthesis of the fourth-generation quinolone antibacterial drug levofloxacin, and (S)—(+)—2—aminobutanol is An important intermediate for the synthesis of anti-tuberculosis drug ethambutol hydrochloride. [0003] US Patent No. 4151204 uses a hydrogenation catalyst to selectively dehydrogenate the 2-position hydroxyl of a series of 1,2-o-diols in an autoclave, and obtain 2-amino-1-alkyl alcohols after amination reduction. Among them, Co-ThO 2 (99:1) component catalyst is the best for cata...

AI Technical Summary

Problems solved by technology

However, the catalytic effect is very poor in the continuous reaction of the fixed bed reactor. The catalyst of Co-Cu (90:10) component is selected, and the reaction is carried out at 180 °C in the fixed bed, and the conversion rate of 1,2-butanediol is 50%. , the selectivity of (R, S)-2-aminobutanol is only 8%

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