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Phosphate biological ceramic microsphere, preparation method and apparatus thereof

A technology of bioceramics and ceramic microspheres, applied in dental preparations, pharmaceutical formulations, medical science, etc., can solve problems such as poor shape and large particle size distribution range of microspheres, and achieve low power, simple equipment, and energy saving Effect

Inactive Publication Date: 2009-04-08
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims at the defect that the microspheres prepared in the prior art have a large particle size distribution range and poor shape, and provides a phosphate bioceramic microsphere and a preparation method thereof, which can prepare particles with uniformly distributed particle diameters and good sphericity. Phosphate Bioceramic Microspheres

Method used

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  • Phosphate biological ceramic microsphere, preparation method and apparatus thereof
  • Phosphate biological ceramic microsphere, preparation method and apparatus thereof
  • Phosphate biological ceramic microsphere, preparation method and apparatus thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0025] (1) Take HA powder and β-TCP powder by mass ratio HA: β-TCP=15: 85, mix evenly;

[0026] (2) taking account for HA and β-TCP mixed powder mass percent is 14% (NaPO 3 ) 6 and Mg(H 2 PO 4 ) 2 Prepare binder solution, wherein (NaPO 3 ) 6 and Mg(H 2 PO 4 ) 2 The mass ratio of is 3: 7; Get the gelatin solution that accounts for 1.5% gelatin of HA and β-TCP mixed powder quality;

[0027] (3) Mix the binder solution prepared in the previous step and the gelatin solution evenly, add the powder in (1) in the mixed solution, and stir to obtain a ceramic slurry;

[0028] (4) if figure 1 As shown, the prepared ceramic slurry is put into the storage tank 4 from the feeding port 1, and the pressure in the storage tank 4 is controlled by the pressure gauge 2 and the pressure control valve 3 to be 0.08 ~ 0.5MPa, so as to ensure that the slurry flows from the pipe The catheter 6 with a diameter of φ0.5-3mm flows out evenly at a rate of 10-60 drops / min. The flow rate can be co...

Embodiment 2

[0031] (1) Take HA powder and β-TCP powder by mass ratio HA: β-TCP=5: 5, mix evenly;

[0032] (2) take account for HA and β-TCP mixed powder mass percentage and be 6% (NaPO 3 ) 6 and Mg(H 2 PO 4 ) 2 Prepare binder solution, wherein (NaPO 3 ) 6 and Mg(H 2 PO 4 ) 2 The mass ratio of is 5: 5; Get the gelatin solution that accounts for 4.5% gelatin mixed powder quality of HA and β-TCP;

[0033] (3) Mix the two solutions prepared in (2) evenly, add the powder in (1) into the mixed solution, and stir evenly to obtain a ceramic slurry;

[0034] (4) Add the prepared ceramic slurry into the storage tank 4 from the feeding port 1, and control the pressure in the storage tank 4 through the pressure gauge 2 and the pressure control valve 3 to be 0.08~0.5MPa, so as to ensure that the slurry flows from the pipe The catheter 6 with a diameter of φ0.5-3mm flows out evenly at a rate of 10-60 drops / min. The flow rate can be controlled by the flow control valve 5, and the droplets drop...

Embodiment 3

[0037] (1) Take HA powder and β-TCP powder by mass ratio HA: β-TCP=3: 7, mix evenly;

[0038] (2) Take 10% (NaPO 3 ) 6 and Mg(H 2 PO 4 ) 2 Prepare binder solution, wherein (NaPO3 ) 6 and Mg(H 2 PO 4 ) 2 The mass ratio of is 6: 4; Get the gelatin solution that accounts for 3% gelatin of HA / β-TCP mixed powder quality;

[0039] (3) Mix the two solutions prepared in (2) evenly, add the powder in (1) into the mixed solution, and stir evenly to obtain a ceramic slurry;

[0040] (4) Add the prepared ceramic slurry into the storage tank 4 from the feed port 1, and control the pressure in the storage tank 4 through the pressure gauge 2 and the pressure control valve 3 to be 0.08-0.5MPa, so as to ensure that the slurry flows from the pipe diameter The catheter 6 with a diameter of φ0.5-3mm flows out evenly at a rate of 10-60 drops / min. The flow rate can be controlled by the flow control valve 5, and the droplets drop into the condensate 7 in the heat preservation container 8 to...

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Abstract

The invention relates to a phosphate bioceramic microsphere, a method and a device for preparing the same. The particle diameter of the phosphate bioceramic microsphere is between phi 0.8 and 4 millimeters; the interior of a particle body is micropores of which the aperture is less than 150 micrometers; the micropores are communicated with each other; the porosity of the micropores is between 65 and 90 percent; and the particle body consists of phosphates of calcium, magnesium and sodium. The method for preparing the phosphate bioceramic microsphere comprises the following steps: step one, weighing HA powder and beta-TCP powder, and mixing the powders evenly; step two, taking (NaPO3)6 and Mg(H2PO4)2 of which the mass is between 5 and 15 percent of the mixed powders of the HA and the beta-TCP to prepare a caking agent solution, and taking a suspending agent of which the mass is between 0.5 and 5 percent of the mixed powders of the HA and the beta-TCP to prepare a suspending agent solution; and step three, evenly mixing the caking agent solution prepared in the step two with the suspending agent solution, then adding the powders prepared in the step one into the obtained solution, and evenly mixing to obtain a ceramic slurry; step four, dripping the ceramic slurry prepared in the step three into a thermal insulation container for condensation to form spherical particles; and step five, cross-linking and sintering the spherical particles after the condensation to obtain the phosphate bioceramic microspheres.

Description

1. Technical field [0001] The invention belongs to the technical field of preparation of bioceramic microspheres, and in particular relates to a droplet-condensation preparation method of phosphate bioceramic microspheres. 2. Background technology [0002] Existing technology: Calcium-phosphorus bioceramics have good biocompatibility and bioactivity, and can form a firm osseointegration with natural bone through biochemical reactions in the body. A large proportion. Ceramic microspheres have excellent properties that many irregular particles do not have, such as high fluidity, high bulk density, not easy to agglomerate, and not easy to cause stress concentration after filling, etc. Currently, they are used in the filling of root canals and extraction sockets, and periodontal disease. Alveolar bone resorption repair, alveolar ridge heightening, mandibular bone cyst cavity filling, atrophic rhinitis filling, mastoid cavity filling, plastic surgery (such as saddle nose beauty)...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/56A61K6/033A61K6/838
Inventor 董寅生王艳莉熊培培盛晓波郭超储成林林萍华
Owner SOUTHEAST UNIV
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