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Glucose responding type polyphosphazene hydrogel and preparation method thereof

A glucose-responsive, polyphosphazene technology, used in pharmaceutical formulations, medical preparations with inactive ingredients, metabolic diseases, etc., can solve the problem of poor material degradation performance, failure to achieve the best effect of drug treatment, and difficulty in satisfying drug release, etc. problem, to achieve the effect of good biocompatibility

Inactive Publication Date: 2009-06-10
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, the polymers used to prepare the above-mentioned glucose-responsive hydrogels are mainly polyacrylamides and polyacrylic acid (esters), but these materials are mostly selected from different monomers for homopolymerization or copolymerization to adjust and control the final polymer. Therefore, the adjustable or controllable range of performance is narrow, it is difficult to meet the needs of drug release, and the best effect of drug treatment cannot be achieved; and the degradation performance of most materials is poor

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  • Glucose responding type polyphosphazene hydrogel and preparation method thereof
  • Glucose responding type polyphosphazene hydrogel and preparation method thereof
  • Glucose responding type polyphosphazene hydrogel and preparation method thereof

Examples

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Embodiment 1

[0026] (1) Preparation of polydichlorophosphazene: 2 g of hexachlorocyclotriphosphazene was sealed in a vacuum glass tube, and reacted at 260° C. for 48 hours. After cooling to room temperature, wash repeatedly with hot dry petroleum ether to remove unreacted monomers and macrocyclic phosphazene by-products, then fully dissolve the residue with dry benzene, filter to remove insoluble matter, and precipitate with petroleum ether , and vacuum-dried to obtain polydichlorophosphazene for use.

[0027] (2) Preparation of 1,2:5,6-di-O-isopropylidene-α-D-glucose: 5g of anhydrous α-D-glucose and 57ml of anhydrous acetone were placed in a Dry the there-necked flask, successively add 3.79g of anhydrous zinc chloride and 0.23ml of 85% phosphoric acid, react at room temperature for 30 hours, filter, and add sodium hydroxide (25mol / L) solution dropwise to the filtrate until neutral. After filtering again, the filtrate was distilled off under reduced pressure to obtain a viscous liquid. T...

Embodiment 2

[0034] Step (1), (2) are the same as embodiment 1

[0035] (3) Preparation of polyphosphazene:

[0036] Place 100ml of dry tetrahydrofuran solution in a three-necked flask with a mechanical stirrer, then add 7.80g (0.03mol) of 1,2:5,6-di-O-isopropylidene-α-D-glucose and 0.75 g (0.033mol) metal sodium, reacted at room temperature for 24 hours. 1.16 g (0.01 mol) of polydichlorophosphazene solution was slowly added dropwise to the above solution, and refluxed for 96 hours. Then a tetrahydrofuran solution (100ml) of sodium methylethoxide (prepared by 0.80ml (0.01mol) methoxyethanol and 0.25g (0.011mol) metallic sodium in tetrahydrofuran at room temperature for 24 hours) was slowly added dropwise to the above solution, After reacting at room temperature for 24 hours, the temperature was raised to 50° C. and the reaction was continued for 24 hours. After centrifuging to remove insoluble matter, remove most of the solvent by rotary evaporation to obtain a viscous liquid, precipita...

Embodiment 3

[0040] Step (1), (2) are the same as embodiment 1

[0041] (3) Preparation of polyphosphazene:

[0042] Place 100ml of dry tetrahydrofuran solution in a three-necked flask with a mechanical stirrer, then add 5.20g (0.02mol) of 1,2:5,6-di-O-isopropylidene-α-D-glucose and 0.50 g (0.022mol) metal sodium, reacted at room temperature for 24 hours. 1.16 g (0.01 mol) of polydichlorophosphazene solution was slowly added dropwise to the above solution, and refluxed for 96 hours. Then a tetrahydrofuran solution (100ml) of sodium methylethoxide (prepared by 1.60ml (0.02mol) methoxyethanol and 0.50g (0.022mol) metallic sodium in tetrahydrofuran at room temperature for 24 hours) was slowly added dropwise to the above solution, After reacting at room temperature for 24 hours, the temperature was raised to 50° C. and the reaction was continued for 24 hours. After centrifuging to remove insoluble matter, remove most of the solvent by rotary evaporation to obtain a viscous liquid, precipita...

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Abstract

The invention relates to a glucose-responsive nitrile polyphosphine hydrogel and a method for preparing the same. The method utilizes interaction between nitrile polyphosphine containing glucose side groups and lectin concanavalin A (Concanavalin A, Con A) to obtain a hydrogel system with different crosslinking degrees and water contents through the proportion increase of the glucose side groups and the selection of a second proper substituting group and a third proper substituting group and other means; and the nitrile polyphosphine hydrogel system has glucose responsiveness, biocompatibility and biodegradability, and can be used for intelligent release of insulin.

Description

Technical field: [0001] The invention relates to a glucose responsive polyphosphazene hydrogel and a preparation method thereof. Background technique: [0002] Diabetes mellitus is a syndrome characterized by persistent high blood sugar as its basic biochemical feature. Currently, it is mainly treated with drugs. Insulin therapy is mainly for patients with high blood sugar after meals, usually manifested as obvious hypoglycemic effect after medication, blood sugar concentration rises again after the drug effect is lost, and insulin can only be administered by injection at present, multiple injections per day Bring great inconvenience to patient's daily life. In addition, due to individual differences or other factors, long-term insulin injections are likely to cause side effects such as hypoglycemia, insulin resistance, hyperinsulinemia, insulin allergy, and edema. Therefore, the medical community has been working hard to find better ways to treat diabetes. For example, s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G79/02C08J3/075A61K47/34A61P3/10C08G79/025
Inventor 蔡晴朴秀玉刘志玲金日光
Owner BEIJING UNIV OF CHEM TECH
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