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Acyclovir enteric-coated formulation composition and method for preparing the same

A technology of enteric-coated preparations and compositions, which is applied in the field of acyclovir enteric-coated preparations and its preparation, can solve problems such as no reports of acyclovir enteric-coated preparations and compositions, and achieve controllable quality of the preparation process Good stability and anti-nausea effect

Inactive Publication Date: 2009-08-12
山东淄博新达制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] According to the search results of relevant patents and prior art literature, there is no relevant report on the composition of acyclovir enteric-coated preparations

Method used

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  • Acyclovir enteric-coated formulation composition and method for preparing the same
  • Acyclovir enteric-coated formulation composition and method for preparing the same
  • Acyclovir enteric-coated formulation composition and method for preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Enteric-coated tablets

[0026] prescription:

[0027]

[0028] Preparation Process:

[0029] Acyclovir, sucrose powder, sodium carboxymethyl starch, starch and magnesium stearate were passed through 80 mesh sieves respectively for later use, and acyclovir, sucrose powder, sodium carboxymethyl starch and starch were weighed according to the prescription amount. After mixing in the mixer, add an appropriate amount of 5% polyvinylpyrrolidone aqueous solution, granulate, granulate, dry at 50°C for 30 minutes, add the prescribed amount of magnesium stearate to the dry granules and mix well, and pass through a 16-mesh sieve with a swing granulator Whole the granules, measure the content of the granules, and determine the tablet weight range, compress the tablets, prepare the enteric coating solution by preparing the coating powder containing the enteric material polyvinyl acetate phthalate with 65% ethanol acetone solution, and then The obtained plain tablet is wrapped ...

Embodiment 2

[0032] Enteric-coated capsules

[0033] prescription:

[0034]

[0035] Preparation Process:

[0036] Pass acyclovir, polyvinylpyrrolidone, microcrystalline cellulose, lactose, and magnesium stearate through an 80-mesh sieve respectively, and weigh acyclovir, polyvinylpyrrolidone, microcrystalline cellulose, lactose, and stearic acid according to the prescription amount Magnesium, put it in a mixer and mix evenly, add 80% ethanol solution to make a soft material, and granulate it in a granulator. The granules prepared above were dried at 45° C. for 30 min. Then pass through a swinging granulator, and use a 20-mesh sieve to sieve the granules. The content of the mixed granules is determined, and the filling capacity of the enteric-coated capsule shell is determined. After passing the inspection, pack.

[0037] The acyclovir enteric-coated capsules prepared by the above method meet the requirements of the relevant testing items stipulated in the "General Rules of Prepara...

Embodiment 3

[0039] Enteric-coated capsules

[0040] prescription:

[0041]

[0042] Preparation Process:

[0043] Pass acyclovir, lactose and dextrin through 80-mesh sieve respectively, weigh acyclovir, lactose and dextrin according to the prescription amount, put them in a mixer and mix them evenly, add 5% starch slurry in an appropriate amount to make a soft material, and put them in the granules Granulate in the machine, dry the granules at 50°C for 45 minutes, then pass through a swing granulator, and sieve the granules with a 20-mesh sieve. The content of the mixed granules is determined, and the filling capacity of the enteric-coated capsule shell is determined. After passing the inspection, pack.

[0044] The acyclovir enteric-coated capsules prepared by the above method meet the requirements of the relevant testing items stipulated in the "General Rules of Preparations" of "Chinese Pharmacopoeia 2005 Edition Part Two".

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Abstract

The invention discloses a group of acyclovir enteric preparation combinations and a preparation method thereof. The group of acyclovir enteric sustained-release preparation combinations are mainly prepared from acyclovir bulk drugs and other appropriate auxiliary materials. The acyclovir enteric preparation provided by the invention can prevent acyclovir from disintegrating in the stomach and causing irritation to gastric mucosa and avoid the adverse reactions caused by the administration, such as nausea, abdominal pain, diarrhea and the like. The acyclovir enteric preparation combination is particularly suitable for patients with stomach-upset diseases. The invention provides a novel form of drug featuring higher safety and better curative effect than the existing relevant acyclovir preparations and having the advantages of high quality controllability and stability of the preparation process.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a group of acyclovir enteric-coated preparation compositions and a preparation method thereof. Background technique [0002] Acyclovir is a purine nucleoside derivative, which is currently under the control of over-the-counter drugs. According to reports, acyclovir has inhibitory effects on herpes simplex virus type I (HSV-1), type H (HSV-2) and varicella zoster virus (VZV) both in vivo and in vitro. The result of cell culture shows that this product has the strongest inhibitory effect on HSV-1 virus, followed by HSV-2 and VZV virus. Due to the affinity of this product to thymidine kinase (TK) encoded by HSV and VZV, it has highly selective inhibitory effect. These viral enzymes convert loratadine to acyclovir monophosphate, a nucleoside analog. Monophosphate is further converted to diphosphate by guanylate kinase in the cell, and then converted to triphosphate by various enzym...

Claims

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Application Information

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IPC IPC(8): A61K31/522A61K9/00A61K9/48A61P31/12
Inventor 贺同庆贾法强安英张慧英张玲玲
Owner 山东淄博新达制药有限公司
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