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Chinese medicine composition for relieving alcoholism and protecting liver and preparation method thereof

A technology for hangover and liver protection and traditional Chinese medicine is applied in the preparation of hangover and liver protection traditional Chinese medicine formulations, and in the field of hangover and liver protection traditional Chinese medicine formulations. time, effects suitable for long-term use

Inactive Publication Date: 2009-08-26
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the composition and preparation method of anti-alcohol and liver-protecting products prepared from Hovenia dulcis, Pueraria lobata, and Schisandra as main raw materials have not been reported yet.

Method used

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  • Chinese medicine composition for relieving alcoholism and protecting liver and preparation method thereof
  • Chinese medicine composition for relieving alcoholism and protecting liver and preparation method thereof
  • Chinese medicine composition for relieving alcoholism and protecting liver and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0060] Experimental example 1: Effects of the extracts of the prescription of anti-alcoholic and liver-protecting traditional Chinese medicine on drunkenness and sobering up of mice

[0061] 50 Kunming male mice (Hubei Provincial Center for Disease Control and Prevention) weighing 18-22 g were randomly divided into 4 groups. There were 12 rats in each group, and they were respectively set as the model control group and the small, medium and high dose groups of the extracts of the traditional Chinese medicine for hangover and liver protection. , Medium and large doses were administered orally, the doses were 0.625, 1.25 and 2.5g of crude drug / kg, and the model control group was administered with 0.2ml / 10g double distilled water, once a day, for 7 consecutive days, and 30 days after the last day of intragastric administration. After ~60 minutes, the four groups were instilled with drunken dose of ethanol, and after 10 minutes, the loss of righting reflex and the recovery time of...

experiment example 2

[0066] Experimental Example 2: Effects of extracts from Chinese herbal prescriptions for relieving alcoholism and protecting the liver on alcoholic liver injury in mice

[0067] Fifty Kunming male mice were randomly divided into 4 groups. There were 12 rats in each group, which were respectively set as the model control group and small, medium and high dose groups of extracts of Chinese herbal medicine for hangover and liver protection. The first group was gavaged with 0.2ml / 10g double distilled water, once a day, for 7 consecutive days, 30-60 minutes after the last day of gavage, all four groups were given a drunk dose of alcohol, and the animals were sacrificed after 6-10 hours of gavage, and the liver was taken out. After treatment, the content of malondialdehyde (MDA) was determined.

[0068] The experimental results (see table 2) show that, compared with the model control group, the liver MDA content of each administration group has a significant reduction, especially in...

experiment example 3

[0072] Experimental Example 3: Effects of Extracts from Chinese Herbal Prescription for Relieving Alcohol and Protecting Liver on Blood Alcohol Concentration in Mice

[0073] The method used in this experiment is headspace gas chromatography, which is currently the most accurate method for measuring blood alcohol.

[0074] Chromatographic conditions:

[0075] Chromatographic column: 4mm×2m stainless steel column, filled with 10% PEG20M, Chromosorb W (60-80 mesh)

[0076] 4mm×2m stainless steel column, built with GDX-201W (60~80 mesh)

[0077] FID detector and gasification chamber temperature: 150°C; column temperature: 100°C. Carrier gas (N 2 ) Flow rate: 45ml / min; H 2 : 35ml / min; Air: 300ml / min.

[0078] operate:

[0079] Add 0.5ml of serum, 0.5ml of internal standard solution, and about 1g of ammonium sulfate into a glass bottle (headspace bottle) of about 10ml, cover it with a polytetrafluoroethylene film and a rubber stopper, seal it with an aluminum cap, sha...

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Abstract

The invention discloses a Chinese medicine composition for relieving alcoholism and protecting liver and a preparation method thereof. The Chine medicine composition is prepared by raw materials of fruit of Japanses raisintree, radices puerarire and shizandra berry. The steps are as follows: A. three medicinal materials of fruit of Japanses raisintree, radices puerarire and shizandra berry are respectively crashed, sieved and mixed in proportion; B. reflux extraction is carried out by ethanol with the concentration of 70%; C. filtering is carried out while hot; D. reflux extraction is carried out by ethanol with the concentration of 70%; E. filtering is carried out while hot; F. the extracting solution is merged for rotatory evaporation till no alcohol taste; G. ethanol is recovered; H. the extracted liquid medicine is dried, displaced in a drier and cooled till room temperature so that dry extract is obtained. The method in the invention is simple and rapid, has high extraction yield and innocuous solvent and is applied to industrial production. The Chinese medicine composition clears heat and promotes diuresis, removes blood stasis and poisonous substance, cures liver and stomach diseases, has the functions of inhibiting absorption of alcohol, promoting evacuation of alcohol, and preventing liver oxidation damage due to alcohol, can strengthen human resistance to alcohol and reduce damage of alcohol to liver.

Description

technical field [0001] The invention relates to the field of medicine and health care, and more specifically relates to a traditional Chinese medicine prescription for hangover and liver protection, and also relates to a preparation method of the traditional Chinese medicine prescription for hangover protection and liver protection. Background technique [0002] Wine is a common beverage in human life. In our country, the unique "wine culture" makes our country's wine market huge and huge in consumption. The negative impact of "wine culture" is acute and chronic alcoholism. Acute heavy drinking can cause nausea, vomiting, memory loss, impairment of fine motor ability, and in severe cases, death can occur due to respiratory muscle paralysis. Studies have shown that among outpatients with acute poisoning, the number of acute alcohol poisoning ranks first or second in the number of emergency patients. Long-term drinking can lead to chronic alcoholism, which can cause fatty l...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61P1/16A61P25/32
Inventor 汪晖李璐奕熊婕杜昕珅梁赅李小军张本坚
Owner WUHAN UNIV
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